Outputs (18)

Evaluating the effects of processing parameters on budesonide nanocrystals prepared by nanomilling (2022)
Journal Article
Olubi, R., Small, W., Burley, J., & Bosquillon, C. (2022). Evaluating the effects of processing parameters on budesonide nanocrystals prepared by nanomilling. British Journal of Pharmacy, 7(2), S1-S2. https://doi.org/10.5920/bjpharm.1140

The aim of this study was to optimise processing parameters in the preparation ofbudesonide nanocrystals by a miniature media milling process performed at labscale. Using Polysorbate 80 as the surfactant choice of stabilizer, the effectof milling bea... Read More about Evaluating the effects of processing parameters on budesonide nanocrystals prepared by nanomilling.

Effect of Excipients on Salt Disproportionation during Dissolution: A Novel Application of In Situ Raman Imaging (2021)
Journal Article
Abouselo, A., Rance, G. A., Tres, F., Taylor, L. S., Kwokal, A., Renou, L., …Aylott, J. W. (2021). Effect of Excipients on Salt Disproportionation during Dissolution: A Novel Application of In Situ Raman Imaging. Molecular Pharmaceutics, 18(9), 3247-3259. https://doi.org/10.1021/acs.molpharmaceut.1c00119

We have employed a bespoke setup combining confocal Raman microscopy and an ultraviolet–visible (UV–Vis) spectroscopy flow cell to investigate the effect of excipients on the disproportionation kinetics of Pioglitazone HCl (PioHCl) in tablets during... Read More about Effect of Excipients on Salt Disproportionation during Dissolution: A Novel Application of In Situ Raman Imaging.

Application of biorelevant saliva-based dissolution for optimisation of orally disintegrating formulations of felodipine (2018)
Journal Article
Ali, J., Zgair, A., Hameed, G. S., Garnett, M. C., Roberts, C. J., Burley, J. C., & Gershkovich, P. (2019). Application of biorelevant saliva-based dissolution for optimisation of orally disintegrating formulations of felodipine. International Journal of Pharmaceutics, 555, 228-236. https://doi.org/10.1016/j.ijpharm.2018.11.051

The oral cavity is of great importance to the performance of orally retained formulations, including: orally disintegrating tablets, taste-masked formulations, and buccal/sublingual delivery systems. With regards to in vitro dissolution assessment of... Read More about Application of biorelevant saliva-based dissolution for optimisation of orally disintegrating formulations of felodipine.

In Silico Screening for Solid Dispersions: The Trouble with Solubility Parameters and χFH (2018)
Journal Article
Turpin, E. R., Taresco, V., Al-Hachami, W. A., Booth, J., Treacher, K., Tomasi, S., …Garnett, M. C. (2018). In Silico Screening for Solid Dispersions: The Trouble with Solubility Parameters and χFH. Molecular Pharmaceutics, 15(10), 4654-4667. https://doi.org/10.1021/acs.molpharmaceut.8b00637

© Copyright 2018 American Chemical Society. The problem of predicting small molecule-polymer compatibility is relevant to many areas of chemistry and pharmaceutical science but particularly drug delivery. Computational methods based on Hildebrand and... Read More about In Silico Screening for Solid Dispersions: The Trouble with Solubility Parameters and χFH.

High-Throughput Miniaturized Screening of Nanoparticle Formation via Inkjet Printing (2018)
Journal Article
Styliari, I. D., Conte, C., Pearce, A. K., Hüsler, A., Cavanagh, R. J., Limo, M. J., …Taresco, V. (2018). High-Throughput Miniaturized Screening of Nanoparticle Formation via Inkjet Printing. Macromolecular Materials and Engineering, 303(8), 1-9. https://doi.org/10.1002/mame.201800146

The self‐assembly of specific polymers into well‐defined nanoparticles (NPs) is of great interest to the pharmaceutical industry as the resultant materials can act as drug delivery vehicles. In this work, a high‐throughput method to screen the abilit... Read More about High-Throughput Miniaturized Screening of Nanoparticle Formation via Inkjet Printing.

Water solubility enhancement of pyrazolo[3,4-d]pyrimidine derivatives via miniaturized polymer-drug microarrays (2018)
Journal Article
Sanna, M., Sicilia, G., Alazzo, A., Singh, N., Musumeci, F., Schenone, S., …Alexander, C. (in press). Water solubility enhancement of pyrazolo[3,4-d]pyrimidine derivatives via miniaturized polymer-drug microarrays. ACS Medicinal Chemistry Letters, 9(3), https://doi.org/10.1021/acsmedchemlett.7b00456

A miniaturized assay was optimized to evaluate the enhanced apparent water solubility of pyrazolo[3,4-d]pyrimidine derivatives used extensively as anticancer drug scaffolds. The applied amount of drugs used in the reported strategy ranged from 5-10 ?... Read More about Water solubility enhancement of pyrazolo[3,4-d]pyrimidine derivatives via miniaturized polymer-drug microarrays.

Rapid nano-gram scale screening method of micro-arrays to evaluate drug-polymer blends using high-throughput printing technology (2017)
Journal Article
Taresco, V., Louzao, I., Scurr, D. J., Turpin, E. R., Laughton, C. A., Alexander, C., …Garnett, M. (in press). Rapid nano-gram scale screening method of micro-arrays to evaluate drug-polymer blends using high-throughput printing technology. Molecular Pharmaceutics, 14(6), https://doi.org/10.1021/acs.molpharmaceut.7b00182

A miniaturized, high-throughput assay was optimized to screen polymer-drug solid dispersions using a 2-D Ink-jet printer. By simply printing nanoliter amounts of polymer and drug solutions onto an inert surface, drug:polymer micro-dots of tunable com... Read More about Rapid nano-gram scale screening method of micro-arrays to evaluate drug-polymer blends using high-throughput printing technology.

New N-acyl amino acid-functionalized biodegradable polyesters for pharmaceutical and biomedical applications (2016)
Journal Article
Taresco, V., Suksiriworapong, J., Styliari, I. D., Argent, R. H., Swainson, S. M., Booth, J., …Garnett, M. C. (in press). New N-acyl amino acid-functionalized biodegradable polyesters for pharmaceutical and biomedical applications. RSC Advances, 6(111), 109401-109405. https://doi.org/10.1039/C6RA21464A

A novel class of biodegradable polyesters has been generated by coupling poly(glycerol adipate) with N-acyl aromatic amino acids. This new set of polymers from this highly versatile polymeric platform may offer unprecedented new opportunities to prod... Read More about New N-acyl amino acid-functionalized biodegradable polyesters for pharmaceutical and biomedical applications.

Properties of acyl modified poly(glycerol-adipate) comb-like polymers and their self-assembly into nanoparticles (2016)
Journal Article
Taresco, V., Suksiriworapong, J., Creasey, R., Burley, J. C., Mantovani, G., Alexander, C., & Garnett, M. (2016). Properties of acyl modified poly(glycerol-adipate) comb-like polymers and their self-assembly into nanoparticles. Journal of Polymer Science Part A: Polymer Chemistry, 54(20), 3267-3278. https://doi.org/10.1002/pola.28215

There is an increasing need to develop bio-compatible polymers with an increased range of different physicochemical properties. Poly(glycerol-adipate) (PGA) is a biocompatible, biodegradable amphiphilic polyester routinely produced from divinyl adipa... Read More about Properties of acyl modified poly(glycerol-adipate) comb-like polymers and their self-assembly into nanoparticles.

Variation in structure and properties of poly(glycerol adipate) via control of chain branching during enzymatic synthesis (2016)
Journal Article
Taresco, V., Creasey, R., Kennon, J., Mantovani, G., Alexander, C., Burley, J. C., & Garnett, M. C. (2016). Variation in structure and properties of poly(glycerol adipate) via control of chain branching during enzymatic synthesis. Polymer, 89, https://doi.org/10.1016/j.polymer.2016.02.036

Poly (glycerol adipate) (PGA) can be produced from divinyl adipate and unprotected glycerol by an enzymatic route to generate a polymer with relatively low molar mass (12 kDa). PGA bears a pendant hydroxyl group which imparts a hydrophilic character... Read More about Variation in structure and properties of poly(glycerol adipate) via control of chain branching during enzymatic synthesis.