Outputs (16)

Effects of Microenvironment and Dosing on Efficiency of Enhanced Cell Penetrating Peptide Nonviral Gene Delivery (2024)
Journal Article
Dixon, J. E., Wellington, V., Elnima, A., & Eltaher, H. M. (2024). Effects of Microenvironment and Dosing on Efficiency of Enhanced Cell Penetrating Peptide Nonviral Gene Delivery. ACS Omega, 9(4), 5014-5023. https://doi.org/10.1021/acsomega.3c09306

Transfection, defined as functional delivery of cell-internalized nucleic acids, is dependent on many factors linked to formulation, vector, cell type, and microenvironmental culture conditions. We previously developed a technology termed glycosamino... Read More about Effects of Microenvironment and Dosing on Efficiency of Enhanced Cell Penetrating Peptide Nonviral Gene Delivery.

Targeted DPPC/DMPG surface-modified voriconazole lipid nanoparticles control invasive pulmonary aspergillosis in immunocompromised population: in-vitro and in-vivo assessment (2023)
Journal Article
Fayyaz, H. A., EL-Massik, M. A., Bahey-El-Din, M., Abdel-Bary, A., Abdallah, O. Y., & Eltaher, H. M. (2024). Targeted DPPC/DMPG surface-modified voriconazole lipid nanoparticles control invasive pulmonary aspergillosis in immunocompromised population: in-vitro and in-vivo assessment. International Journal of Pharmaceutics, 649, Article 123663. https://doi.org/10.1016/j.ijpharm.2023.123663

Invasive pulmonary aspergillosis (IPA) is the most devastating Aspergillus-related lung disease. Voriconazole (VRZ) is the first-line treatment against IPA. Despite availability in oral and parenteral dosage forms, risks of systemic toxicity dictate... Read More about Targeted DPPC/DMPG surface-modified voriconazole lipid nanoparticles control invasive pulmonary aspergillosis in immunocompromised population: in-vitro and in-vivo assessment.

Bioinspired 3D-printed scaffold embedding DDAB-nano ZnO/nanofibrous microspheres for regenerative diabetic wound healing (2023)
Journal Article
Metwally, W. M., El-Habashy, S. E., El-Hosseiny, L. S., Essawy, M. M., Eltaher, H. M., El-Khordagui, L., & El-Khordagui, L. K. (2023). Bioinspired 3D-printed scaffold embedding DDAB-nano ZnO/nanofibrous microspheres for regenerative diabetic wound healing. Biofabrication, 16(1), Article 015001. https://doi.org/10.1088/1758-5090/acfd60

There is a constant demand for novel materials/biomedical devices to accelerate the healing of hard-to-heal wounds. Herein, an innovative 3D-printed bioinspired construct was developed as an antibacterial/regenerative scaffold for diabetic wound heal... Read More about Bioinspired 3D-printed scaffold embedding DDAB-nano ZnO/nanofibrous microspheres for regenerative diabetic wound healing.

Nano zinc oxide-functionalized nanofibrous microspheres: A bioactive hybrid platform with antimicrobial, regenerative and hemostatic activities (2023)
Journal Article
Metwally, W. M., El-Habashy, S. E., El-Nikhely, N. A., Mahmoud, H. E., Eltaher, H. M., & El-Khordagui, L. (2023). Nano zinc oxide-functionalized nanofibrous microspheres: A bioactive hybrid platform with antimicrobial, regenerative and hemostatic activities. International Journal of Pharmaceutics, 638, Article 122920. https://doi.org/10.1016/j.ijpharm.2023.122920

Bioactive hybrid constructs are at the cutting edge of innovative biomaterials. PLA nanofibrous microspheres (NF-MS) were functionalized with zinc oxide nanoparticles (nZnO) and DDAB-modified nZnO (D-nZnO) for developing inorganic/nano-microparticula... Read More about Nano zinc oxide-functionalized nanofibrous microspheres: A bioactive hybrid platform with antimicrobial, regenerative and hemostatic activities.

Biomedical applications of bio-degradable green composites (2023)
Book Chapter
El-Khordagui, L. K., Eltaher, H. M., & Said, S. S. (2023). Biomedical applications of bio-degradable green composites. In Inamuddin, & T. Altalhi (Eds.), Green sustainable process for chemical and environmental engineering and science biomedical applications of green composites (55-110). Elsevier. https://doi.org/10.1016/b978-0-323-95169-2.00002-x

This chapter provides an overview of the biomedical applications of biodegradable green composites with emphasis on drug delivery, tissue engineering, wound care, personal hygiene, 3D printing and biosensing. Biodegradable green composites were appra... Read More about Biomedical applications of bio-degradable green composites.

Direct contact-mediated non-viral gene therapy using thermo-sensitive hydrogel-coated dressings (2022)
Journal Article
Eltaher, H. M., Blokpoel Ferreras, L. A., Jalal, A. R., & Dixon, J. (2022). Direct contact-mediated non-viral gene therapy using thermo-sensitive hydrogel-coated dressings. Biomaterials Advances, 143, Article 213177. https://doi.org/10.1016/j.bioadv.2022.213177

Nanotechnologies are being increasingly applied as systems for peptide and nucleic acid macromolecule drug delivery. However systemic targeting of these, or efficient topical and localized delivery remains an issue. A controlled release system that c... Read More about Direct contact-mediated non-viral gene therapy using thermo-sensitive hydrogel-coated dressings.

Prodigiosin-Functionalized Probiotic Ghosts as a Bioinspired Combination Against Colorectal Cancer Cells (2022)
Journal Article
Saleh, N., Mahmoud, H. E., Eltaher, H., Helmy, M., El-Khordagui, L., & Hussein, A. A. (2022). Prodigiosin-Functionalized Probiotic Ghosts as a Bioinspired Combination Against Colorectal Cancer Cells. Probiotics and Antimicrobial Proteins, https://doi.org/10.1007/s12602-022-09980-y

Lactobacillus acidophilus ghosts (LAGs) with the unique safety of a probiotic, inherent tropism for colon cells, and multiple bioactivities offer promise as drug carriers for colon targeting. Our objective was to evaluate LAGs functionalized with pro... Read More about Prodigiosin-Functionalized Probiotic Ghosts as a Bioinspired Combination Against Colorectal Cancer Cells.

Abstract 1917 NON‐VIRAL GENE EDITING APPROACHES TO GENETICALLY AUGMENT AND CORRECT CYSTIC FIBROSIS USING MUCUS PENETRATING PEPTIDE NANOPARTICLES (2022)
Journal Article
Savage, A. M., Eltaher, H., Soo Suk, J., & Dixon, J. E. (2022). Abstract 1917 NON‐VIRAL GENE EDITING APPROACHES TO GENETICALLY AUGMENT AND CORRECT CYSTIC FIBROSIS USING MUCUS PENETRATING PEPTIDE NANOPARTICLES. Tissue Engineering Part A, 28(S1),

RAPID INTRAOPERATIVE GENETIC AUGMENTATION OF AUTOGRAFTS FOR RECONSTRUCTIVE SURGERY OF SEVERE TRAUMA (2022)
Journal Article
Dixon, J., Thi Mai, T., McLaren, J., Ollivere, B., Scammell, B., & Eltaher, H. (2022). RAPID INTRAOPERATIVE GENETIC AUGMENTATION OF AUTOGRAFTS FOR RECONSTRUCTIVE SURGERY OF SEVERE TRAUMA. Tissue Engineering: Parts A, B, and C, 28(S1),

Survivors with severe tissue injury have unmet clinical needs for better bone and soft tissue regeneration. Specifically they have progressive tissue loss due to inflammation, necrosis, infection and the development of critical size bone defects is a... Read More about RAPID INTRAOPERATIVE GENETIC AUGMENTATION OF AUTOGRAFTS FOR RECONSTRUCTIVE SURGERY OF SEVERE TRAUMA.

Enhanced oral permeability of Trans-Resveratrol using nanocochleates for boosting anticancer efficacy; in-vitro and ex-vivo appraisal (2021)
Journal Article
El-Melegy, M. G., Eltaher, H. M., Gaballah, A., & El-Kamel, A. H. (2021). Enhanced oral permeability of Trans-Resveratrol using nanocochleates for boosting anticancer efficacy; in-vitro and ex-vivo appraisal. European Journal of Pharmaceutics and Biopharmaceutics, 168, 166-183. https://doi.org/10.1016/j.ejpb.2021.08.020

Hepatocellular carcinoma (HCC) is a prevalent liver cancer representing the fourth most lethal cancer worldwide. Trans-Resveratrol (T-R) possesses a promising anticancer activity against HCC. However, it suffers from poor bioavailability because of t... Read More about Enhanced oral permeability of Trans-Resveratrol using nanocochleates for boosting anticancer efficacy; in-vitro and ex-vivo appraisal.