Outputs (21)

Apoptotic cell death in disease—Current understanding of the NCCD 2023 (2023)
Journal Article
Vitale, I., Pietrocola, F., Guilbaud, E., Aaronson, S. A., Abrams, J. M., Adam, D., …Galluzzi, L. (2023). Apoptotic cell death in disease—Current understanding of the NCCD 2023. Cell Death and Differentiation, 30(5), 1097-1154. https://doi.org/10.1038/s41418-023-01153-w

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this p... Read More about Apoptotic cell death in disease—Current understanding of the NCCD 2023.

The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer (2023)
Journal Article
Metzler, V. M., de Brot, S., Haigh, D. B., Woodcock, C. L., Lothion-Roy, J., Harris, A. E., …Jeyapalan, J. N. (2023). The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer. Frontiers in Cell and Developmental Biology, 11, Article 1116424. https://doi.org/10.3389/fcell.2023.1116424

Histone H3 lysine 4 (H3K4) methylation is key epigenetic mark associated with active transcription and is a substrate for the KDM1A/LSD1 and KDM5B/JARID1B lysine demethylases. Increased expression of KDM1A and KDM5B is implicated in many cancer types... Read More about The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer.

Decision letter: Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation (2022)
Other
(2022). Decision letter: Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation

PIP5K1α is Required for Promoting Tumor Progression in Castration-Resistant Prostate Cancer (2022)
Journal Article
Wang, T., Sarwar, M., Whitchurch, J. B., Collins, H. M., Green, T., Semenas, J., …Persson, J. L. (2022). PIP5K1α is Required for Promoting Tumor Progression in Castration-Resistant Prostate Cancer. Frontiers in Cell and Developmental Biology, 10, Article 798590. https://doi.org/10.3389/fcell.2022.798590

PIP5K1α has emerged as a promising drug target for the treatment of castration-resistant prostate cancer (CRPC), as it acts upstream of the PI3K/AKT signaling pathway to promote prostate cancer (PCa) growth, survival and invasion. However, little is... Read More about PIP5K1α is Required for Promoting Tumor Progression in Castration-Resistant Prostate Cancer.

FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer (2021)
Journal Article
Larsson, P. F., Karlsson, R., Sarwar, M., Miftakhova, R., Wang, T., Syed Khaja, A. S., …Persson, J. L. (2022). FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer. Molecular Oncology, https://doi.org/10.1002/1878-0261.13166

Low-affinity immunoglobulin gamma Fc region receptor III-A (FcγRIIIa) is a cell surface protein that belongs to a family of Fc receptors that facilitate the protective function of the immune system against pathogens. However, the role of FcγRIIIa in... Read More about FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer.

Synthesis of micellar-like terpolymer nanoparticles with reductively-cleavable cross-links and evaluation of efficacy in 2D and 3D models of triple negative breast cancer (2020)
Journal Article
Monteiro, P. F., Gulfam, M., Monteiro, C. J., Travanut, A., Abelha, T. F., Pearce, A. K., …Alexander, C. (2020). Synthesis of micellar-like terpolymer nanoparticles with reductively-cleavable cross-links and evaluation of efficacy in 2D and 3D models of triple negative breast cancer. Journal of Controlled Release, 323, 549-564. https://doi.org/10.1016/j.jconrel.2020.04.049

© 2020 Elsevier B.V. Triple negative or basal-like breast cancer (TNBC) is characterised by aggressive progression, lack of standard therapies and poorer overall survival rates for patients. The bad prognosis, high rate of relapse and resistance agai... Read More about Synthesis of micellar-like terpolymer nanoparticles with reductively-cleavable cross-links and evaluation of efficacy in 2D and 3D models of triple negative breast cancer.

Invasive Lobular Breast Cancer as a Distinct Disease: Implications for Therapeutic Strategy (2019)
Journal Article
Luveta, J., Parks, R. M., Heery, D. M., Cheung, K., & Johnston, S. J. (2020). Invasive Lobular Breast Cancer as a Distinct Disease: Implications for Therapeutic Strategy. Oncology and Therapy, 8, 1-11. https://doi.org/10.1007/s40487-019-00105-0

Invasive lobular carcinoma comprises 10–15% of all breast cancers and is increasingly recognised as a distinct and understudied disease compared with the predominant histological subtype, invasive ductal carcinoma. Hallmarks of invasive lobular carci... Read More about Invasive Lobular Breast Cancer as a Distinct Disease: Implications for Therapeutic Strategy.

GSK3β-SCFFBXW7α mediated phosphorylation and ubiquitination of IRF1 are required for its transcription-dependent turnover (2019)
Journal Article
Garvin, A. J., Khalaf, A. H., Rettino, A., Xicluna, J., Butler, L., Morris, J. R., …Clarke, N. M. (2019). GSK3β-SCFFBXW7α mediated phosphorylation and ubiquitination of IRF1 are required for its transcription-dependent turnover. Nucleic Acids Research, 47(9), 4476-4494. https://doi.org/10.1093/nar/gkz163

IRF1 (Interferon Regulatory Factor-1) is the prototype of the IRF family of DNA binding transcription factors. IRF1 protein expression is regulated by transient up-regulation in response to external stimuli followed by rapid degradation via the ubiqu... Read More about GSK3β-SCFFBXW7α mediated phosphorylation and ubiquitination of IRF1 are required for its transcription-dependent turnover.

Predicting puberty in partial androgen insensitivity syndrome: use of clinical and functional androgen receptor indices (2018)
Journal Article
Lek, N., Tadokoro-Cuccaro, R., Whitchurch, J. B., Mazumder, B., Miles, H., Prentice, P., …Hughes, I. A. (2018). Predicting puberty in partial androgen insensitivity syndrome: use of clinical and functional androgen receptor indices. EBioMedicine, 36, 401-409. https://doi.org/10.1016/j.ebiom.2018.09.047

Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system (2018)
Journal Article
Lee, J. B., Zgair, A., Malec, J., Kim, T. H., Kim, M. G., Ali, J., …Gershkovich, P. (2018). Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system. Journal of Controlled Release, 286, 10-19. https://doi.org/10.1016/j.jconrel.2018.07.022

The intestinal lymphatic system plays an important role in the pathophysiology of multiple diseases including lymphomas, cancer metastasis, autoimmune diseases, and human immunodeficiency virus (HIV) infection. It is thus an important compartment for... Read More about Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system.