Outputs (4)

Eukaryotic translation initiation factor 4All contributes to microRNA-122 regulation of hepatitis C virus replication (2018)
Journal Article
Ahmed, C., Winlow, P. L., Parsons, A. L., & Jopling, C. L. (2018). Eukaryotic translation initiation factor 4All contributes to microRNA-122 regulation of hepatitis C virus replication. Nucleic Acids Research, 46(12), https://doi.org/10.1093/nar/gky262

Hepatitis C virus (HCV) is a positive sense RNA virus that persistently infects human liver, leading to cirrhosis and hepatocellular carcinoma. HCV replication requires the liver-specific microRNA-122 (miR-122). In contrast to canonical miRNA-mediat... Read More about Eukaryotic translation initiation factor 4All contributes to microRNA-122 regulation of hepatitis C virus replication.

Microprocessor mediates transcriptional termination of long noncoding RNA transcripts hosting microRNAs (2015)
Journal Article
Dhir, A., Dhir, S., Proudfoot, N. J., & Jopling, C. L. (2015). Microprocessor mediates transcriptional termination of long noncoding RNA transcripts hosting microRNAs. Nature Structural and Molecular Biology, 22, https://doi.org/10.1038/nsmb.2982

MicroRNA (miRNA) play a major role in the post-transcriptional regulation of gene expression. Mammalian miRNA biogenesis begins with co-transcriptional cleavage of RNA polymerase II (Pol II) transcripts by the Microprocessor complex. While most miRNA... Read More about Microprocessor mediates transcriptional termination of long noncoding RNA transcripts hosting microRNAs.

Stop that nonsense! (2014)
Journal Article
Jopling, C. L. (2014). Stop that nonsense!. eLife, 3, https://doi.org/10.7554/elife.04300

Copyright © 2014, Jopling. Cells can avoid the effects of so-called 'nonsense' mutations by several methods, including a newly discovered mechanism driven by microRNA molecules.

The P body protein LSm1 contributes to stimulation of hepatitis C virus translation, but not replication, by microRNA-122 (2013)
Journal Article
Roberts, A. P., Doidge, R., Tarr, A. W., & Jopling, C. L. (2014). The P body protein LSm1 contributes to stimulation of hepatitis C virus translation, but not replication, by microRNA-122. Nucleic Acids Research, 42(2), 1257-1269. https://doi.org/10.1093/nar/gkt941

The P body protein LSm1 stimulates translation and replication of hepatitis C virus (HCV). As the liver-specific microRNA-122 (miR-122) is required for HCV replication and is associated with P bodies, we investigated whether regulation of HCV by LSm1... Read More about The P body protein LSm1 contributes to stimulation of hepatitis C virus translation, but not replication, by microRNA-122.