Outputs (29)

Co-assembling living material as an in vitro lung epithelial infection model (2023)
Journal Article
Wu, Y., Romero, M., Robertson, S. N., Fenn, S., Fisher, L., Willingham, I., …Mata, A. (2024). Co-assembling living material as an in vitro lung epithelial infection model. Matter, 7(1), 216-236. https://doi.org/10.1016/j.matt.2023.10.029

Biofilms are robust living 3D materials that play key roles in nature but also cause major problems, such as tolerance to antibiotic treatment. Recreation of these living structures in vitro is critical to understand their biology and develop solutio... Read More about Co-assembling living material as an in vitro lung epithelial infection model.

Bioactive and chemically defined hydrogels with tunable stiffness guide cerebral organoid formation and modulate multi-omics plasticity in cerebral organoids (2023)
Journal Article
Isik, M., Okesola, B. O., Eylem, C. C., Kocak, E., Nemutlu, E., D'Este, M., …Derkus, B. (2023). Bioactive and chemically defined hydrogels with tunable stiffness guide cerebral organoid formation and modulate multi-omics plasticity in cerebral organoids. Acta Biomaterialia, 171, 223-238. https://doi.org/10.1016/j.actbio.2023.09.040

Organoids are an emerging technology with great potential in human disease modelling, drug development, diagnosis, tissue engineering, and regenerative medicine. Organoids as 3D-tissue culture systems have gained special attention in the past decades... Read More about Bioactive and chemically defined hydrogels with tunable stiffness guide cerebral organoid formation and modulate multi-omics plasticity in cerebral organoids.

Elastin-like recombinamer-mediated hierarchical mineralization coatings on Zr-16Nb-xTi (x=4,16wt%) alloy surfaces improve biocompatibility (2023)
Journal Article
Xue, R., Deng, X., Xu, X., Tian, Y., Hasan, A., Mata, A., …Liu, L. (2023). Elastin-like recombinamer-mediated hierarchical mineralization coatings on Zr-16Nb-xTi (x=4,16wt%) alloy surfaces improve biocompatibility. Biomaterials Advances, 151, Article 213471. https://doi.org/10.1016/j.bioadv.2023.213471

The biocompatibility of biomedical materials is vital to their applicability and functionality. However, modifying surfaces for enhanced biocompatibility using traditional surface treatment techniques is challenging. We employed a mineralizing elasti... Read More about Elastin-like recombinamer-mediated hierarchical mineralization coatings on Zr-16Nb-xTi (x=4,16wt%) alloy surfaces improve biocompatibility.

Synthetic extracellular matrices with function-encoding peptides (2023)
Journal Article
Ligorio, C., & Mata, A. (2023). Synthetic extracellular matrices with function-encoding peptides. Nature Reviews Bioengineering, 1, 518–536. https://doi.org/10.1038/s44222-023-00055-3

The communication of cells with their surroundings is mostly encoded in the epitopes of structural and signalling proteins present in the extracellular matrix (ECM). These peptide epitopes can be incorporated in biomaterials to serve as function-enco... Read More about Synthetic extracellular matrices with function-encoding peptides.

Biomaterial-based platforms for tumour tissue engineering (2023)
Journal Article
Curvello, R., Kast, V., Ordóñez-Morán, P., Mata, A., & Loessner, D. (2023). Biomaterial-based platforms for tumour tissue engineering. Nature Reviews Materials, 8, 314–330. https://doi.org/10.1038/s41578-023-00535-3

Tissue engineering has produced innovative tools for cancer research. 3D cancer models based on molecularly designed biomaterials aim to harness the dimensionality and biomechanical and biochemical properties of tumour tissues. However, to date, desp... Read More about Biomaterial-based platforms for tumour tissue engineering.

Peptide–Protein Coassemblies into Hierarchical and Bioactive Tubular Membranes (2023)
Journal Article
Majkowska, A., Inostroza-Brito, K. E., Gonzalez, M., Redondo-Gómez, C., Rice, A., Rodriguez-Cabello, J. C., …Mata, A. (2023). Peptide–Protein Coassemblies into Hierarchical and Bioactive Tubular Membranes. Biomacromolecules, 24(10), 4419-4429. https://doi.org/10.1021/acs.biomac.2c01095

Multicomponent self-assembly offers opportunities for the design of complex and functional biomaterials with tunable properties. Here, we demonstrate how minor modifications in the molecular structures of peptide amphiphiles (PAs) and elastin-like re... Read More about Peptide–Protein Coassemblies into Hierarchical and Bioactive Tubular Membranes.

Disinfector-Assisted Low Temperature Reduced Graphene Oxide-Protein Surgical Dressing for the Postoperative Photothermal Treatment of Melanoma (2022)
Journal Article
Wu, Y., Yang, J., van Teijlingen, A., Berardo, A., Corridori, I., Feng, J., …Mata, A. (2022). Disinfector-Assisted Low Temperature Reduced Graphene Oxide-Protein Surgical Dressing for the Postoperative Photothermal Treatment of Melanoma. Advanced Functional Materials, 32(38), Article 2205802. https://doi.org/10.1002/adfm.202205802

Materials that combine the functionalities of both of proteins and graphene are of great interest for the engineering of biosensing, drug delivery, and regenerative devices. Graphene oxide (GO) offers an opportunity to design GO-protein interactions... Read More about Disinfector-Assisted Low Temperature Reduced Graphene Oxide-Protein Surgical Dressing for the Postoperative Photothermal Treatment of Melanoma.

Mineralizing Coating on 3D Printed Scaffolds for the Promotion of Osseointegration (2022)
Journal Article
Hasan, A., Bagnol, R., Owen, R., Latif, A., Rostam, H. M., Elsharkawy, S., …Mata, A. (2022). Mineralizing Coating on 3D Printed Scaffolds for the Promotion of Osseointegration. Frontiers in Bioengineering and Biotechnology, 10, Article 836386. https://doi.org/10.3389/fbioe.2022.836386

Design and fabrication of implants that can perform better than autologous bone grafts remain an unmet challenge for the hard tissue regeneration in craniomaxillofacial applications. Here, we report an integrated approach combining additive manufactu... Read More about Mineralizing Coating on 3D Printed Scaffolds for the Promotion of Osseointegration.

Embracing complexity in biomaterials design (2022)
Journal Article
Azevedo, H. S., & Mata, A. (2022). Embracing complexity in biomaterials design. Personnel Assessment and Decisions, 6, Article 100039. https://doi.org/10.1016/j.bbiosy.2022.100039

Animate materials, man-made materials behaving like living systems, are attracting enormous interest across a range of sectors, from construction and transport industry to medicine. In this leading opinion article, we propose that embracing complexit... Read More about Embracing complexity in biomaterials design.

Disordered Protein Stabilization by Co-Assembly of Short Peptides Enables Formation of Robust Membranes (2021)
Journal Article
Ghosh, M., Majkowska, A., Mirsa, R., Bera, S., Rodríguez-Cabello, J. C., Mata, A., & Adler-Abramovich, L. (2022). Disordered Protein Stabilization by Co-Assembly of Short Peptides Enables Formation of Robust Membranes. ACS Applied Materials and Interfaces, 14(1), 464-473. https://doi.org/10.1021/acsami.1c22136

Molecular self-assembly is a spontaneous natural process resulting in highly ordered nano to microarchitectures. We report temperature-independent formation of robust stable membranes obtained by the spontaneous interaction of intrinsically disordere... Read More about Disordered Protein Stabilization by Co-Assembly of Short Peptides Enables Formation of Robust Membranes.