Skip to main content

Research Repository

Advanced Search

Outputs (75)

Formation of hollow carbon nanoshells from thiol stabilised silver nanoparticles via heat treatment (2018)
Journal Article
Watts, J. A., Fay, M. W., Rance, G. A., Brown, P. D., & Khlobystov, A. N. (2018). Formation of hollow carbon nanoshells from thiol stabilised silver nanoparticles via heat treatment. Carbon, 139, 538-544. https://doi.org/10.1016/j.carbon.2018.06.074

Uniform, less 10 nm sized, hollow carbon nano-shells (HCNS) have been prepared via a single-step, thermal treatment of alkanethiol stabilised Ag nanoparticles (TS-AgNP). Direct evidence for the formation of spherical HCNS from TS-AgNP is provided by... Read More about Formation of hollow carbon nanoshells from thiol stabilised silver nanoparticles via heat treatment.

Carbene in Cupredoxin Protein Scaffolds: Replacement of a Histidine Ligand in the Active Site Substantially Alters Copper Redox Properties (2018)
Journal Article
Planchestainer, M., Segaud, N., Shanmugam, M., McMaster, J., Paradisi, F., & Albrecht, M. (2018). Carbene in Cupredoxin Protein Scaffolds: Replacement of a Histidine Ligand in the Active Site Substantially Alters Copper Redox Properties. Angewandte Chemie International Edition, 57(33), 10677-10682. https://doi.org/10.1002/anie.201807168

© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim N-heterocyclic carbene (NHC) ligands have had a major impact in homogeneous catalysis, however, their potential role in biological systems is essentially unexplored. We replaced a copper-coordinatin... Read More about Carbene in Cupredoxin Protein Scaffolds: Replacement of a Histidine Ligand in the Active Site Substantially Alters Copper Redox Properties.

Tuning the electronic structure of organic–inorganic hybrid polyoxometalates: The crucial role of the covalent linkage (2018)
Journal Article
Kibler, A. J., & Newton, G. N. (2018). Tuning the electronic structure of organic–inorganic hybrid polyoxometalates: The crucial role of the covalent linkage. Polyhedron, 154, 1-20. https://doi.org/10.1016/j.poly.2018.06.027

The covalent organofunctionalization of polyoxometalates (POMs) has been widely used to both control and enhance their redox properties, particularly for applications in catalysis, energy storage, optics and molecular magnetism. The design of such sy... Read More about Tuning the electronic structure of organic–inorganic hybrid polyoxometalates: The crucial role of the covalent linkage.

Enantioselective synthesis of chiral cyclopent-2-enones by nickel-catalyzed desymmetrization of malonate esters (2018)
Journal Article
Karad, S. N., Panchal, H., Clarke, C., Lewis, W., & Lam, H. W. (2018). Enantioselective synthesis of chiral cyclopent-2-enones by nickel-catalyzed desymmetrization of malonate esters. Angewandte Chemie International Edition, 57(29), 9122-9125. https://doi.org/10.1002/anie.201805578

The enantioselective synthesis of highly functionalized chiral cyclopent‐2‐enones by the reaction of alkynyl malonate esters with arylboronic acids is described. These desymmetrizing arylative cyclizations are catalyzed by a chiral phosphinooxazoline... Read More about Enantioselective synthesis of chiral cyclopent-2-enones by nickel-catalyzed desymmetrization of malonate esters.

Copper-Catalyzed Chan–Lam Cyclopropylation of Phenols and Azaheterocycles (2018)
Journal Article
Derosa, J., O’Duill, M. L., Holcomb, M., Boulous, M. N., Patman, R. L., Wang, F., …Engle, K. M. (2018). Copper-Catalyzed Chan–Lam Cyclopropylation of Phenols and Azaheterocycles. Journal of Organic Chemistry, 83(7), 3417-3425. https://doi.org/10.1021/acs.joc.7b03100

Small molecules containing cyclopropane-heteroatom linkages are commonly needed in medicinal chemistry campaigns yet are problematic to prepare using existing methods. To address this issue, a scalable Chan-Lam cyclopropylation reaction using potassi... Read More about Copper-Catalyzed Chan–Lam Cyclopropylation of Phenols and Azaheterocycles.

Tridentate Directing Groups Stabilize 6-Membered Palladacycles in Catalytic Alkene Hydrofunctionalization (2017)
Journal Article
O’Duill, M. L., Matsuura, R., Wang, Y., Turnbull, J. L., Gurak, J. A., Gao, D., …Engle, K. M. (2017). Tridentate Directing Groups Stabilize 6-Membered Palladacycles in Catalytic Alkene Hydrofunctionalization. Journal of the American Chemical Society, 139(44), 15576-15579. https://doi.org/10.1021/jacs.7b08383

Removable tridentate directing groups inspired by pincer ligands have been designed to stabilize otherwise kinetically and thermodynamically disfavored 6-membered alkyl palladacycle intermediates. This family of directing groups enables regioselectiv... Read More about Tridentate Directing Groups Stabilize 6-Membered Palladacycles in Catalytic Alkene Hydrofunctionalization.

Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis (2017)
Journal Article
Gahloth, D., Dunstan, M. S., Quaglia, D., Klumbys, E., Lockhart-Cairns, M. P., Hill, A. M., …Leys, D. (2017). Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis. Nature Chemical Biology, 13(9), 975-981. https://doi.org/10.1038/nchembio.2434

Carboxylic acid reductase (CAR) catalyzes the ATP- and NADPH-dependent reduction of carboxylic acids to the corresponding aldehydes. The enzyme is related to the nonribosomal peptide synthetases, consisting of an adenylation domain fused via a peptid... Read More about Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis.

Palladium(II)-Catalyzed Directed anti-Hydrochlorination of Unactivated Alkynes with HCl (2017)
Journal Article
Derosa, J., Cantu, A. L., Boulous, M. N., O’Duill, M. L., Turnbull, J. L., Liu, Z., …Engle, K. M. (2017). Palladium(II)-Catalyzed Directed anti-Hydrochlorination of Unactivated Alkynes with HCl. Journal of the American Chemical Society, 139(14), 5183-5193. https://doi.org/10.1021/jacs.7b00892

A regioselective anti-hydrochlorination of unactivated alkynes is reported. The reaction utilizes in situ generated HCl as the source of both the Cl - and H + and is catalyzed by palladium(II) acetate, with loadings as low as 25 ppm. Removable picoli... Read More about Palladium(II)-Catalyzed Directed anti-Hydrochlorination of Unactivated Alkynes with HCl.