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Ion mobility-mass spectrometry reveals conformational flexibility in the deubiquitinating enzyme USP5 (2015)
Journal Article
Scott, D., Layfield, R., & Oldham, N. J. (2015). Ion mobility-mass spectrometry reveals conformational flexibility in the deubiquitinating enzyme USP5. Proteomics, 15(16), https://doi.org/10.1002/pmic.201400457

Many proteins exhibit conformation flexibility as part of their biological function, whether through the presence of a series of well-defined states or by the existence of intrinsic disorder. Ion mobility spectrometry, in combination with MS (IM–MS),... Read More about Ion mobility-mass spectrometry reveals conformational flexibility in the deubiquitinating enzyme USP5.

The functional repertoire of survivin's tails (2015)
Journal Article
Wheatley, S. P. (2015). The functional repertoire of survivin's tails. Cell Cycle, 14(2), https://doi.org/10.4161/15384101.2014.979680

Survivin is a multitasking protein that can inhibit cell death and that is essential for mitosis. Due to these prosurvival activities and the correlation of its expression with tumour resistance to conventional cancer treatments, survivin has receive... Read More about The functional repertoire of survivin's tails.

Molecular insights into DNA interference by CRISPR-associated nuclease-helicase Cas3 (2014)
Journal Article
Gong, B., Shin, M., Sun, J., Jung, C., Bolt, E. L., van der oost, J., & Kim, J. (2014). Molecular insights into DNA interference by CRISPR-associated nuclease-helicase Cas3. Proceedings of the National Academy of Sciences, 111(46), https://doi.org/10.1073/pnas.1410806111

Mobile genetic elements in bacteria are neutralized by a system based on clustered regularly interspaced short palindromic repeats (CRISPRs) and CRISPR-associated (Cas) proteins. Type I CRISPR-Cas systems use a “Cascade” ribonucleoprotein complex to... Read More about Molecular insights into DNA interference by CRISPR-associated nuclease-helicase Cas3.

Analysis of the functional repertoire of a mutant form of survivin, K129E, which has been linked to lung cancer (2014)
Journal Article
Aljaberi, A. M., Webster, J. R., & Wheatley, S. P. (in press). Analysis of the functional repertoire of a mutant form of survivin, K129E, which has been linked to lung cancer. Cancer Cell International, 14, Article 78. https://doi.org/10.1186/s12935-014-0078-8

Background Survivin is a protein that is normally present only in G2 and M-phases in somatic cells, however, in cancer cells, it is expressed throughout the cell cycle. A prosurvival factor, survivin is both an inhibitor of apoptosis and an essentia... Read More about Analysis of the functional repertoire of a mutant form of survivin, K129E, which has been linked to lung cancer.

Etiology of the membrane potential of rat white fat adipocytes (2014)
Journal Article
Bentley, D. C., Pulbutr, P., Chan, S., & Smith, P. A. (2014). Etiology of the membrane potential of rat white fat adipocytes. AJP - Endocrinology and Metabolism, 307(2), E161-E175. https://doi.org/10.1152/ajpendo.00446.2013

The plasma membrane potential (Vm) is key to many physiological processes, however its ionic aetiology in white fat adipocytes is poorly characterised. To address this question, we have employed the perforated patch current-clamp and cell-attached pa... Read More about Etiology of the membrane potential of rat white fat adipocytes.

Novel hypoglycemic injury mechanism: N-methyl-D-aspartate receptor-mediated white matter damage (2014)
Journal Article
Yang, X., Hamner, M. A., Brown, A. M., Evans, R. D., Ye, Z., Chen, S., & Ransom, B. R. (2014). Novel hypoglycemic injury mechanism: N-methyl-D-aspartate receptor-mediated white matter damage. Annals of Neurology, 75(4), https://doi.org/10.1002/ana.24050

Objective: Hypoglycemia is a common adverse event and can injure central nervous system (CNS) white matter (WM). We determined if glutamate receptors were involved in hypoglycemic WM injury. Methods: Mouse optic nerves (MON), CNS WM tracts, were mai... Read More about Novel hypoglycemic injury mechanism: N-methyl-D-aspartate receptor-mediated white matter damage.

Transient transcriptional events in human skeletal muscle at the outset of concentric resistance exercise training (2014)
Journal Article
Murton, A. J., Billeter, R., Stephens, F. B., Des Etages, S., Graber, F., Hill, R., …Greenhaff, P. L. (2014). Transient transcriptional events in human skeletal muscle at the outset of concentric resistance exercise training. Journal of Applied Physiology, 116(1), https://doi.org/10.1152/japplphysiol.00426.2013

We sought to ascertain the time course of transcriptional events that occur in human skeletal muscle at the outset of resistance exercise (RE) training in RE naive individuals and determine whether the magnitude of response was associated with exerci... Read More about Transient transcriptional events in human skeletal muscle at the outset of concentric resistance exercise training.

Surgical resection of primary tumour improves aerobic performance in colorectal cancer (2013)
Journal Article
Williams, J. P., Nyasavajjala, S. M., Phillips, B. E., Chakrabarty, M., & Lund, J. N. (2014). Surgical resection of primary tumour improves aerobic performance in colorectal cancer. EJSO - European Journal of Surgical Oncology, 40(2), https://doi.org/10.1016/j.ejso.2013.11.009

Background Colorectal cancer is the third most common cancer in the UK, with patients suffering declines in muscle mass and aerobic function. We hypothesised that tumour removal in non-metastatic colorectal cancer would lead to a restoration of le... Read More about Surgical resection of primary tumour improves aerobic performance in colorectal cancer.