Outputs (141)

UDP-sugars activate P2Y 14 receptors to mediate vasoconstriction of the porcine coronary artery (2017)
Journal Article
Abbas, Z. S., Latif, M. L., Dovlatova, N., Fox, S. C., Heptinstall, S., Dunn, W. R., & Ralevic, V. (2018). UDP-sugars activate P2Y 14 receptors to mediate vasoconstriction of the porcine coronary artery. Vascular Pharmacology, 103-105, https://doi.org/10.1016/j.vph.2017.12.063

Aims UDP-sugars can act as extracellular signalling molecules, but relatively little is known about their cardiovascular actions. The P2Y14 receptor is a Gi/o-coupled receptor which is activated by UDP-glucose and related sugar nucleotides. In thi... Read More about UDP-sugars activate P2Y 14 receptors to mediate vasoconstriction of the porcine coronary artery.

Results of the FIRST STEPS study: a randomised controlled trial and economic evaluation of the Group Family Nurse Partnership (gFNP) programme compared to routine care in improving outcomes for high-risk mothers and their children and preventing abuse (2017)
Journal Article
Barnes, J., Stuart, J., Allen, E., Petrou, S., Sturgess, J., Barlow, J., …Elbourne, D. (2017). Results of the FIRST STEPS study: a randomised controlled trial and economic evaluation of the Group Family Nurse Partnership (gFNP) programme compared to routine care in improving outcomes for high-risk mothers and their children and preventing abuse. Public Health Research, 5(9), https://doi.org/10.3310/phr05090

Background: Family Nurse Partnership (FNP) is a home-based nurse home-visiting programme to support vulnerable parents. Group FNP (gFNP) has similar aims and materials and was demonstrated to be feasible in implementation evaluations. Objectives: To... Read More about Results of the FIRST STEPS study: a randomised controlled trial and economic evaluation of the Group Family Nurse Partnership (gFNP) programme compared to routine care in improving outcomes for high-risk mothers and their children and preventing abuse.

Process and impact of dialectical behaviour therapy: a systematic review of perceptions of clients with a diagnosis of borderline personality disorder (2017)
Journal Article
Little, H., Tickle, A., & das Nair, R. (2018). Process and impact of dialectical behaviour therapy: a systematic review of perceptions of clients with a diagnosis of borderline personality disorder. Psychology and Psychotherapy: Theory, Research and Practice, 91(3), 278-301. https://doi.org/10.1111/papt.12156

Purpose: To identify, appraise and synthesise findings from qualitative studies of individuals diagnosed with Borderline Personality Disorder who have experienced Dialectical Behaviour Therapy, to gain further understanding of their perceptions of t... Read More about Process and impact of dialectical behaviour therapy: a systematic review of perceptions of clients with a diagnosis of borderline personality disorder.

Healthcare costs of transarterial chemoembolization in the treatment of hepatocellular carcinoma (2017)
Journal Article
Fateen, W., Khan, F., O’Neill, R., James, M., Ryder, S., & Aithal, G. (2017). Healthcare costs of transarterial chemoembolization in the treatment of hepatocellular carcinoma. Journal of Hepatocellular Carcinoma, 2017(4), https://doi.org/10.2147/JHC.S144068

Background: A meta-analysis comparing drug-eluting beads transarterial chemoembolization (DEB-TACE) with conventional transarterial chemoembolization (cTACE) has recently been published. On balance, no significant differences were found in terms of o... Read More about Healthcare costs of transarterial chemoembolization in the treatment of hepatocellular carcinoma.

Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans (2017)
Journal Article
Valdes, A. M., Ravipati, S., Menni, C., Abhishek, A., Metrustry, S., Harris, J., …Barrett, D. A. (in press). Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans. Scientific Reports, 7, Article 10748. https://doi.org/10.1038/s41598-017-09516-3

Resolvins are omega-3 fatty acid derived potent bioactive lipids that resolve inflammation and modulate transient receptor potential channels. Exogenous administration of the resolvin precursor 17-HDHA shows a strong analgesic effect in animal models... Read More about Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans.

The differential contribution of the innate immune system to a good pathological response in the breast and axillary lymph nodes induced by neoadjuvant chemotherapy in women with large and locally advanced breast cancers (2017)
Journal Article
Kaewkangsadan, V., Verma, C., Eremin, J. M., Cowley, G. P., Ilyas, M., Satthaporn, S., & Eremin, O. (2017). The differential contribution of the innate immune system to a good pathological response in the breast and axillary lymph nodes induced by neoadjuvant chemotherapy in women with large and locally advanced breast cancers. Journal of Immunology Research, 2017, Article 1049023. https://doi.org/10.1155/2017/1049023

The tumour microenvironment consists of malignant cells, stroma, and immune cells. The role of adaptive immunity in inducing a pathological complete response (pCR) in breast cancer with neoadjuvant chemotherapy (NAC) is well studied. The contribution... Read More about The differential contribution of the innate immune system to a good pathological response in the breast and axillary lymph nodes induced by neoadjuvant chemotherapy in women with large and locally advanced breast cancers.

Glargine and degludec: solution behaviour of higher dose synthetic insulins (2017)
Journal Article
Adams, G. G., Alzahrani, Q., Jiwani, S. I., Meal, A., Morgan, P. S., Coffey, F., …Gillis, R. B. (2017). Glargine and degludec: solution behaviour of higher dose synthetic insulins. Scientific Reports, 7(1), Article 7287. https://doi.org/10.1038/s41598-017-06642-w

Single, double and triple doses of the synthetic insulins glargine and degludec currently used in patient therapy are characterised using macromolecular hydrodynamic techniques (dynamic light scattering and analytical ultracentrifugation) in an attem... Read More about Glargine and degludec: solution behaviour of higher dose synthetic insulins.

Sexual offending hierarchies, personality attributions, and the clinical implications (2017)
Journal Article
Challinor, L. E., & Duff, S. (2017). Sexual offending hierarchies, personality attributions, and the clinical implications. Journal of Forensic Practice, 19(3), https://doi.org/10.1108/JFP-07-2016-0031

Aims: the research examines sexual offending hierarchies constructed by the general public and forensic staff based on personal attitudes and perceived severity of offence. In addition, six sexual offence perpetrators are differentiated using the Fiv... Read More about Sexual offending hierarchies, personality attributions, and the clinical implications.

Liver cirrhosis in England--an observational study: are we measuring its burden occurrence correctly? (2017)
Journal Article
Ratib, S., West, J., & Fleming, K. M. (2017). Liver cirrhosis in England--an observational study: are we measuring its burden occurrence correctly?. BMJ Open, 7(7), Article e013752. https://doi.org/10.1136/bmjopen-2016-013752

Objectives: Mortality due to liver disease (of which cirrhosis is the end‐stage) is increasing more than any other chronic condition in the UK. This study aims to demonstrate that (i) exclusive reliance on mortality rates may not reveal the true burd... Read More about Liver cirrhosis in England--an observational study: are we measuring its burden occurrence correctly?.

Integrative analysis of copy number and gene expression in breast cancer using formalin-fixed paraffin-embedded core biopsy tissue: a feasibility study (2017)
Journal Article
Iddawela, M., Rueda, O., Eremin, J., Eremin, O., Cowley, J., Earl, H. M., & Caldas, C. (in press). Integrative analysis of copy number and gene expression in breast cancer using formalin-fixed paraffin-embedded core biopsy tissue: a feasibility study. BMC Genomics, 18(1), https://doi.org/10.1186/s12864-017-3867-3

Background: An absence of reliable molecular markers has hampered individualised breast cancer treatments, and a major limitation for translational research is the lack of fresh tissue. There are, however, abundant banks of formalinfixed paraffin-emb... Read More about Integrative analysis of copy number and gene expression in breast cancer using formalin-fixed paraffin-embedded core biopsy tissue: a feasibility study.