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Outputs (23)

Analgesic efficacy and safety of morphine in the Procedural Pain in Premature Infants (Poppi) study: randomised placebo-controlled trial (2018)
Journal Article
Hartley, C., Moultrie, F., Hoskin, A., Green, G., Monk, V., Bell, J. L., …Slater, R. (2018). Analgesic efficacy and safety of morphine in the Procedural Pain in Premature Infants (Poppi) study: randomised placebo-controlled trial. Lancet, 392(10164), 2595-2605. https://doi.org/10.1016/S0140-6736%2818%2931813-0

Background: Infant pain has immediate and long-term effects but is undertreated because of a paucity of evidence-based analgesics. Although morphine is often used to sedate ventilated infants, its analgesic efficacy is unclear. We aimed to establish... Read More about Analgesic efficacy and safety of morphine in the Procedural Pain in Premature Infants (Poppi) study: randomised placebo-controlled trial.

Central masked adjudication of stroke diagnosis at trial entry offered no advantage over diagnosis by local clinicians: secondary analysis and simulation (2018)
Journal Article
Godolphin, P., Hepburn, T., Sprigg, N., Walker, L., Berge, E., Collins, R., …Montgomery, A. (2018). Central masked adjudication of stroke diagnosis at trial entry offered no advantage over diagnosis by local clinicians: secondary analysis and simulation. Contemporary Clinical Trials Communications, 12, 176-181. https://doi.org/10.1016/j.conctc.2018.11.002

Background Central adjudication of stroke type is commonly implemented in large multicentre clinical trials. We investigated the effect of central adjudication of diagnosis of stroke type at trial entry in the Efficacy of Nitric Oxide in Stroke (E... Read More about Central masked adjudication of stroke diagnosis at trial entry offered no advantage over diagnosis by local clinicians: secondary analysis and simulation.

Pulse Oximeter Saturation Targeting and Oximeter Changes in the Benefits of Oxygen Saturation Targeting (BOOST)-II Australia and BOOST-II UK Oxygen Trials (2018)
Journal Article
Stenson, B. J., Donoghoe, M., Brocklehurst, P., Davis, P. G., Juszczak, E., Marschner, I. C., …Tarnow-Mordi, W. O. (2019). Pulse Oximeter Saturation Targeting and Oximeter Changes in the Benefits of Oxygen Saturation Targeting (BOOST)-II Australia and BOOST-II UK Oxygen Trials. Journal of Pediatrics, 204, 301-304.E2. https://doi.org/10.1016/j.jpeds.2018.08.033

Infants in the Australian and UK Benefits of Oxygen Saturation Targeting-II trials treated using revised oximeters spent more time within their planned pulse oximeter saturation target ranges than infants treated using the original oximeters (P 

Factors associated with physiotherapists' preference for MRI in primary care patients with low back and leg pain (2018)
Journal Article
Ely, S., Stynes, S., Ogollah, R., Foster, N. E., & Konstantinou, K. (2018). Factors associated with physiotherapists' preference for MRI in primary care patients with low back and leg pain. Musculoskeletal Science and Practice, 38, 46-52. https://doi.org/10.1016/j.msksp.2018.09.003

© 2018 Background: Criticisms about overuse of MRI in low back pain are well documented. Yet, with the exception of suspicion of serious pathology, little is known about factors that influence clinicians’ preference for magnetic resonance imaging (MR... Read More about Factors associated with physiotherapists' preference for MRI in primary care patients with low back and leg pain.

Robust assessment of two-treatment higher-order cross-over designs against missing values (2018)
Journal Article
Godolphin, P., & Godolphin, E. (2019). Robust assessment of two-treatment higher-order cross-over designs against missing values. Computational Statistics and Data Analysis, 132, 31-45. https://doi.org/10.1016/j.csda.2018.06.020

© 2018 Elsevier B.V. In scientific experiments where human behaviour or animal response is intrinsically involved, such as clinical trials, there is a strong possibility of recording missing values. Missing data in a clinical trial has the potential... Read More about Robust assessment of two-treatment higher-order cross-over designs against missing values.

Postpartum evaluation of cardiovascular disease risk for women with pregnancies complicated by hypertension (2018)
Journal Article
Escouto, D. C., Green, A., Kurlak, L., Walker, K., Loughna, P., Chappell, L., …Bramham, K. (2018). Postpartum evaluation of cardiovascular disease risk for women with pregnancies complicated by hypertension. Pregnancy Hypertension, 13, 218-224. https://doi.org/10.1016/j.preghy.2018.06.019

Objectives: Postpartum stratification of cardiovascular risk for women with pregnancies complicated by pre-eclampsia is challenging. Our aim was to identify potential clinical and biomarker predictors of future cardiovascular risk at six weeks postpa... Read More about Postpartum evaluation of cardiovascular disease risk for women with pregnancies complicated by hypertension.

Botulinum toxins for the prevention of migraine in adults (2018)
Journal Article
Herd, C. P., Tomlinson, C. L., Rick, C., Scotton, W. J., Edwards, J., Ives, N., …Sinclair, A. (2018). Botulinum toxins for the prevention of migraine in adults. Cochrane Database of Systematic Reviews, Article CD011616. https://doi.org/10.1002/14651858.CD011616.pub2

Background Migraine occurs in around 15% of adults and is ranked as the seventh most disabling disease amongst all diseases globally. Despite the available treatments many people suffer prolonged and frequent attacks which have a major impact on the... Read More about Botulinum toxins for the prevention of migraine in adults.

Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration (2018)
Journal Article
Askie, L. M., Darlow, B. A., Finer, N., Schmidt, B., Stenson, B., Tarnow-Mordi, W., …for the Neonatal Oxygenation Prospective Meta-analysis (NeOProM) Collaboration. (2018). Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration. Journal of the American Medical Association, 319(21), 2190–2201. https://doi.org/10.1001/jama.2018.5725

IMPORTANCE There are potential benefits and harms of hyperoxemia and hypoxemia for extremely preterm infants receiving more vs less supplemental oxygen. OBJECTIVE To compare the effects of different target ranges for oxygen saturation asmeasured b... Read More about Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration.