Skip to main content

Research Repository

Advanced Search

Outputs (52)

The efficacy of ‘static’ training interventions for improving indices of cardiorespiratory fitness in premenopausal females (2018)
Journal Article
Herrod, P. J. J., Blackwell, J. E. M., Moss, B. F., Gates, A., Atherton, P. J., Lund, J. N., …Phillips, B. E. (2019). The efficacy of ‘static’ training interventions for improving indices of cardiorespiratory fitness in premenopausal females. European Journal of Applied Physiology, 119(3), 645-652. https://doi.org/10.1007/s00421-018-4054-1

PURPOSE: Cardiovascular disease (CVD) is the leading cause of death worldwide. Many risk factors for CVD can be modified pharmacologically; however, uptake of medications is low, especially in asymptomatic people. Exercise is also effective at reduc... Read More about The efficacy of ‘static’ training interventions for improving indices of cardiorespiratory fitness in premenopausal females.

Worms in space for outreach on earth: space life science activities for the classroom (2018)
Journal Article
Gaffney, C. J., Pollard, A. K., Deane, C. S., Cooke, M., Balsamo, M., Hewitt, J., …Phillips, B. E. (2018). Worms in space for outreach on earth: space life science activities for the classroom. Gravitational and space research : publication of the American Society for Gravitational and Space Research, 6(2), 74-82

Long term spaceflight is associated with the loss of skeletal muscle mass and function. The Molecular Muscle Experiment (MME) seeks to identify the causes of muscle decline in space and test potential therapies to attenuate this in the microscopic wo... Read More about Worms in space for outreach on earth: space life science activities for the classroom.

Effect of non-meat, high protein supplementation on quality of life and clinical outcomes for older people living in care homes: systematic review and meta-analysis (2018)
Journal Article
Donaldson, A., Smith, T. O., Alder, S., Johnstone, A. M., De Roos, B., Aucott, L. S., …Myint, P. K. (2019). Effect of non-meat, high protein supplementation on quality of life and clinical outcomes for older people living in care homes: systematic review and meta-analysis. Nutrition Reviews, 77(2), 116-127. https://doi.org/10.1093/nutrit/nuy061

CONTEXT: Care home residents are at risk of malnutrition through reduced overall food intake, ‘anabolic resistance’ in ageing muscle and high prevalence of medical morbidity and functional dependency. There has been limited consensus regarding effect... Read More about Effect of non-meat, high protein supplementation on quality of life and clinical outcomes for older people living in care homes: systematic review and meta-analysis.

A systematic review on the pharmacokinetics of cannabidiol in humans (2018)
Journal Article
Millar, S. A., Stone, N. L., Yates, A. S., & O 'Sullivan, S. E. (2018). A systematic review on the pharmacokinetics of cannabidiol in humans. Frontiers in Pharmacology, 9, 1-13

Background: Cannabidiol is being pursued as a therapeutic treatment for multiple conditions, usually by oral delivery. Animal studies suggest oral bioavailability is low, but literature in humans is not sufficient. The aim of this review was to colla... Read More about A systematic review on the pharmacokinetics of cannabidiol in humans.

An analysis of endocannabinoid concentrations and mood following singing and exercise in healthy volunteers (2018)
Journal Article
Stone, N. L., Millar, S. A., Herrod, P. J. J., Barrett, D. A., Ortori, C. A., Mellon, V. A., & O’Sullivan, S. E. (2018). An analysis of endocannabinoid concentrations and mood following singing and exercise in healthy volunteers. Frontiers in Behavioral Neuroscience, 12, 1-10. https://doi.org/10.3389/fnbeh.2018.00269

© 2018 Stone, Millar, Herrod, Barrett, Ortori, Mellon and O’Sullivan. The euphoric feeling described after running is, at least in part, due to increased circulating endocannabinoids (eCBs). eCBs are lipid signaling molecules involved in reward, appe... Read More about An analysis of endocannabinoid concentrations and mood following singing and exercise in healthy volunteers.

Determinants of motivation to quit in smokers screened for the early detection of lung cancer: a qualitative study (2018)
Journal Article
Young, B., Vedhara, K., Kendrick, D., Littleford, R., Robertson, J. F. R., Sullivan, F. M., …in collaboration with the ECLS study team. (2018). Determinants of motivation to quit in smokers screened for the early detection of lung cancer: a qualitative study. BMC Public Health, 18(1), Article 1276. https://doi.org/10.1186/s12889-018-6211-1

Background: The promotion of smoking cessation within lung cancer screening could lead to benefits for smoking-related disease and improve cost-effectiveness of screening. Little is known about how smokers respond to lung cancer screening and how thi... Read More about Determinants of motivation to quit in smokers screened for the early detection of lung cancer: a qualitative study.

Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans (2018)
Journal Article
Gaffney, C. J., Pollard, A., Barratt, T. F., Constantin-Teodosiu, D., Greenhaff, P. L., & Szewczyk, N. J. (2018). Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans. Aging, 10(11), 3382-3396. https://doi.org/10.18632/aging.101654

Sarcopenia, the age-related decline of muscle, is a significant and growing public health burden. C. elegans, a model organism for investigating the mechanisms of ageing, also displays sarcopenia, but the underlying mechanism(s) remain elusive. Here,... Read More about Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans.

Individual and combined relationship between reduced eGFR and/or increased urinary albumin excretion rate with mortality risk among insulin treated patients with Type 2 diabetes in routine practice (2018)
Journal Article
Anyanwagu, U., Donnelly, R., & Idris, I. (2019). Individual and combined relationship between reduced eGFR and/or increased urinary albumin excretion rate with mortality risk among insulin treated patients with Type 2 diabetes in routine practice. Kidney Diseases, 5(2), 91–99. https://doi.org/10.1159/000493731

Background: Low estimated glomerular filtration rate (eGFR) and increased urinary albumin-to-creatinine ratio (ACR) are well-recognised prognostic markers of cardiovascular (CV) risk, but their individual and combine relationship with CV disease and... Read More about Individual and combined relationship between reduced eGFR and/or increased urinary albumin excretion rate with mortality risk among insulin treated patients with Type 2 diabetes in routine practice.

Quality improvement collaborative aiming for Proactive HEAlthcare of Older People in Care Homes (PEACH): a realist evaluation protocol (2018)
Journal Article
Devi, R., Meyer, J., Banerjee, J., Goodman, C., Gladman, J. R., Dening, T., …Gordon, A. L. (2018). Quality improvement collaborative aiming for Proactive HEAlthcare of Older People in Care Homes (PEACH): a realist evaluation protocol. BMJ Open, 8(11), 1-7. https://doi.org/10.1136/bmjopen-2018-023287

Introduction: This protocol describes a study of a Quality Improvement Collaborative (QIC) to support implementation and delivery of Comprehensive Geriatric Assessment (CGA) in UK care homes. The QIC will be formed of health and social care professio... Read More about Quality improvement collaborative aiming for Proactive HEAlthcare of Older People in Care Homes (PEACH): a realist evaluation protocol.

Muscle strength deficiency and mitochondrial dysfunction in a muscular dystrophy model of C. elegans and its functional response to drugs (2018)
Journal Article
Hewitt, J. E., Pollard, A. K., Lesanpezeshki, L., Deane, C. S., Gaffney, C. J., Etheridge, T., …Vanapalli, S. A. (2018). Muscle strength deficiency and mitochondrial dysfunction in a muscular dystrophy model of C. elegans and its functional response to drugs. Disease Models and Mechanisms, 11(12), https://doi.org/10.1242/dmm.036137

Muscle strength is a key clinical parameter used to monitor the progression of human muscular dystrophies including Duchenne and Becker muscular dystrophies. Although Caenorhabditis elegans is an established genetic model for studying mechanisms and... Read More about Muscle strength deficiency and mitochondrial dysfunction in a muscular dystrophy model of C. elegans and its functional response to drugs.