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Outputs (21)

Co-infection in critically ill patients with COVID-19: an observational cohort study from England (2021)
Journal Article
Baskaran, V., Lawrence, H., Lansbury, L., Webb, K., Safavi, S., Zainuddin, I., Huq, T., Eggleston, C., Ellis, J., Thakker, C., Charles, B., Boyd, S., Williams, T., Phillips, C., Redmore, E., Platt, S., Hamilton, E., Barr, A., Venyo, L., Wilson, P., …Shen Lim, W. (2021). Co-infection in critically ill patients with COVID-19: an observational cohort study from England. Journal of Medical Microbiology, 70(4), Article 001350. https://doi.org/10.1099/jmm.0.001350

Introduction: During previous viral pandemics, reported co-infection rates and implicated pathogens have varied. In the 1918 influenza pandemic, a large proportion of severe illness and death was complicated by bacterial co-infection, predominantly S... Read More about Co-infection in critically ill patients with COVID-19: an observational cohort study from England.

Prognostic significance of heat shock protein 90AA1 (HSP90α) in invasive breast cancer (2021)
Journal Article
Alsaeed, S. A., Toss, M., Alsaleem, M., Aleskandarany, M., Joseph, C., Kurozumi, S., Ball, G., Mongan, N., Green, A., & Rakha, E. (2022). Prognostic significance of heat shock protein 90AA1 (HSP90α) in invasive breast cancer. Journal of Clinical Pathology, 75(4), 263-269. https://doi.org/10.1136/jclinpath-2020-207106

Aims: The mechanisms that drive breast cancer (BC) progression and poor outcome are not fully understood. The human heat shock protein 90 alpha family class A member 1 (HSP90α) encoded by the HSP90 'A1 gene has a vital role in cellular responses to s... Read More about Prognostic significance of heat shock protein 90AA1 (HSP90α) in invasive breast cancer.

Reduced biomechanical models for precision-cut lung-slice stretching experiments (2021)
Journal Article
Pybus, H. J., Tatler, A. L., Edgar, L. T., O’Dea, R. D., & Brook, B. S. (2021). Reduced biomechanical models for precision-cut lung-slice stretching experiments. Journal of Mathematical Biology, 82(5), Article 35. https://doi.org/10.1007/s00285-021-01578-2

Precision-cut lung-slices (PCLS), in which viable airways embedded within lung parenchyma are stretched or induced to contract, are a widely used ex vivo assay to investigate bronchoconstriction and, more recently, mechanical activation of proremodel... Read More about Reduced biomechanical models for precision-cut lung-slice stretching experiments.

Outcomes for children with acquired brain injury (ABI) admitted to acute neurorehabilitation (2021)
Journal Article
Keetley, R., Bennett, E., Williams, J., Stewart, I., Whitehouse, W., Pilling, P., & Manning, J. (2021). Outcomes for children with acquired brain injury (ABI) admitted to acute neurorehabilitation. Developmental Medicine and Child Neurology, 63(7), 824-830. https://doi.org/10.1111/dmcn.14846

Aim: To evaluate an innovative paediatric neurorehabilitation model in relation to improving quality of neurorehabilitation and reducing length of stay (LOS).

Method: Process evaluation approach was conducted in line with Medical Research Council... Read More about Outcomes for children with acquired brain injury (ABI) admitted to acute neurorehabilitation.

Outcomes for children with acquired brain injury (ABI) admitted to acute neurorehabilitation (2021)
Journal Article
Keetley, R., Bennett, E., Williams, J., Stewart, I., Whitehouse, W. P., Pilling, P., & Manning, J. C. (2021). Outcomes for children with acquired brain injury (ABI) admitted to acute neurorehabilitation. Developmental Medicine and Child Neurology, 63(7), 824-830. https://doi.org/10.1111/dmcn.14846

Aim: To evaluate an innovative paediatric neurorehabilitation model in relation to improving quality of neurorehabilitation and reducing length of stay (LOS) for children with acquired brain injury. Method: A process evaluation approach was conducted... Read More about Outcomes for children with acquired brain injury (ABI) admitted to acute neurorehabilitation.

Array-based measurements of aero-allergen-specific IgE correlate with skin-prick test reactivity in asthma regardless of specific IgG4 or total IgE measurements (2021)
Journal Article
Hamed, A., Todd, I., Tighe, P. J., Powell, R. J., Harrison, T., & Fairclough, L. (2021). Array-based measurements of aero-allergen-specific IgE correlate with skin-prick test reactivity in asthma regardless of specific IgG4 or total IgE measurements. Journal of Immunological Methods, 492, Article 112999. https://doi.org/10.1016/j.jim.2021.112999

© 2021 Elsevier B.V. Skin prick testing (SPT) and measurement of serum allergen-specific IgE (sIgE) are used to investigate asthma and other allergic conditions. Measurement of serum total IgE (tIgE) and allergen-specific IgG4 (sIgG4) may also be use... Read More about Array-based measurements of aero-allergen-specific IgE correlate with skin-prick test reactivity in asthma regardless of specific IgG4 or total IgE measurements.

The feasibility and tolerability of using Inspiratory Muscle Training (IMT) with adults discharged from the hospital with community-acquired pneumonia (CAP) (2021)
Journal Article
Pick, H., Faghy, M., Cresswell, G., Ashton, D., Bolton, C., McKeever, T., Lim, W., & Bewick, T. (2021). The feasibility and tolerability of using Inspiratory Muscle Training (IMT) with adults discharged from the hospital with community-acquired pneumonia (CAP). Advances in Respiratory Medicine, 89, 216-220. https://doi.org/10.5603/ARM.a2021.0002

Background: Patients experience substantial morbidity following discharge from hospital and during recovery from community-acquired pneumonia (CAP). Inspiratory muscle training (IMT) has demonstrated improved functional capacity and reduced patient-r... Read More about The feasibility and tolerability of using Inspiratory Muscle Training (IMT) with adults discharged from the hospital with community-acquired pneumonia (CAP).

Systematic review and meta-analysis of anakinra, sarilumab, siltuximab and tocilizumab for COVID-19 (2021)
Journal Article
Khan, F. A., Stewart, I., Fabbri, L., Moss, S., Robinson, K., Smyth, A. R., & Jenkins, G. (2021). Systematic review and meta-analysis of anakinra, sarilumab, siltuximab and tocilizumab for COVID-19. Thorax, 76(9), 907-919. https://doi.org/10.1136/thoraxjnl-2020-215266

Background There is accumulating evidence for an overly activated immune response in severe COVID-19, with several studies exploring the therapeutic role of immunomodulation. Through systematic review and meta-analysis, we assess the effectiveness of... Read More about Systematic review and meta-analysis of anakinra, sarilumab, siltuximab and tocilizumab for COVID-19.

A systematic review and meta-analysis of Anakinra, Sarilumab, Siltuximab and Tocilizumab for Covid-19 (2021)
Preprint / Working Paper
Khan, F., Fabbri, L., Stewart, I., Robinson A., K., Smyth, A. R., & Jenkins, G. A systematic review and meta-analysis of Anakinra, Sarilumab, Siltuximab and Tocilizumab for Covid-19

Background There is accumulating evidence for an overly activated immune response in severe Covid-19, with several studies exploring the therapeutic role of immunomodulation. Through systematic review and meta-analysis, we assess the effectiveness of... Read More about A systematic review and meta-analysis of Anakinra, Sarilumab, Siltuximab and Tocilizumab for Covid-19.