Outputs (44)

Predominant DNMT and TET mediate effects of allergen on the human bronchial epithelium in a controlled air pollution exposure study (2020)
Journal Article
Li, H., Ryu, M. H., Rider, C. F., Tse, W., Clifford, R. L., Aristizabal, M. J., …Carlsten, C. (2021). Predominant DNMT and TET mediate effects of allergen on the human bronchial epithelium in a controlled air pollution exposure study. Journal of Allergy and Clinical Immunology, 147(5), 1671-1682. https://doi.org/10.1016/j.jaci.2020.08.044

Background

Epidemiological data show that traffic-related air pollution contributes to the increasing prevalence and severity of asthma. DNA methylation (DNAm) changes may elucidate adverse health effects of environmental exposures.

Objectives... Read More about Predominant DNMT and TET mediate effects of allergen on the human bronchial epithelium in a controlled air pollution exposure study.

CHAARM: A model to predict uncertainties in indoor pollutant concentrations, ventilation and infiltration rates, and associated energy demand in Chilean houses (2020)
Journal Article
Molina, C., Jones, B., Hall, I. P., & Sherman, M. H. (2021). CHAARM: A model to predict uncertainties in indoor pollutant concentrations, ventilation and infiltration rates, and associated energy demand in Chilean houses. Energy and Buildings, 230, Article 110539. https://doi.org/10.1016/j.enbuild.2020.110539

Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study (2020)
Journal Article
Drake, T. M., Docherty, A. B., Harrison, E. M., Quint, J. K., Adamali, H., Agnew, S., …ISARIC4C Investigators. (2020). Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study. American Journal of Respiratory and Critical Care Medicine, 202(12), 1656–1665. https://doi.org/10.1164/rccm.202007-2794oc

Rationale: The impact of COVID-19 on patients with Interstitial Lung Disease (ILD) has not been established. Objectives: To assess outcomes in patients with ILD hospitalized for COVID-19 versus those without ILD in a contemporaneous age, sex and como... Read More about Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study.

TWIST1 DNA methylation is a cell marker of airway and parenchymal lung fibroblasts that are differentially methylated in asthma (2020)
Journal Article
Clifford, R. L., Yang, C. X., Fishbane, N., Patel, J., MacIsaac, J. L., McEwen, L. M., …Hackett, T. L. (2020). TWIST1 DNA methylation is a cell marker of airway and parenchymal lung fibroblasts that are differentially methylated in asthma. Clinical Epigenetics, 12(1), Article 145. https://doi.org/10.1186/s13148-020-00931-4

© 2020 The Author(s). Background: Mesenchymal fibroblasts are ubiquitous cells that maintain the extracellular matrix of organs. Within the lung, airway and parenchymal fibroblasts are crucial for lung development and are altered with disease, but it... Read More about TWIST1 DNA methylation is a cell marker of airway and parenchymal lung fibroblasts that are differentially methylated in asthma.

Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis (2020)
Journal Article
John, A. E., Graves, R. H., Pun, K. T., Vitulli, G., Forty, E. J., Mercer, P. F., …Slack, R. J. (2020). Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis. Nature Communications, 11(1), Article 4659. https://doi.org/10.1038/s41467-020-18397-6

Composite type-2 biomarker strategy versus a symptom–risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial (2020)
Journal Article
Heaney, L. G., Busby, J., Hanratty, C. E., Djukanovic, R., Woodcock, A., Walker, S. M., …Yang, F. (2021). Composite type-2 biomarker strategy versus a symptom–risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial. Lancet Respiratory Medicine, 9(1), 57-68. https://doi.org/10.1016/s2213-2600%2820%2930397-0

Background
Asthma treatment guidelines recommend increasing corticosteroid dose to control symptoms and reduce exacerbations. This approach is potentially flawed because symptomatic asthma can occur without corticosteroid responsive type-2 (T2)-driv... Read More about Composite type-2 biomarker strategy versus a symptom–risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial.

Short physical performance battery as a practical tool to assess mortality risk in chronic obstructive pulmonary disease (2020)
Journal Article
Fermont, J. M., Mohan, D., Fisk, M., Bolton, C. E., Macnee, W., Cockcroft, J. R., …Polkey, M. I. (2021). Short physical performance battery as a practical tool to assess mortality risk in chronic obstructive pulmonary disease. Age and Ageing, 50(3), 795-801. https://doi.org/10.1093/ageing/afaa138

RATIONALE: chronic obstructive pulmonary disease (COPD) is a leading cause of mortality and common in older adults. The BODE Index is the most recognised mortality risk score in COPD but includes a 6-minute walk test (6MWT) that is seldom available i... Read More about Short physical performance battery as a practical tool to assess mortality risk in chronic obstructive pulmonary disease.

Submaximal Eccentric Cycling in People With COPD: Acute Whole-Body Cardiopulmonary and Muscle Metabolic Responses (2020)
Journal Article
Ward, T. J. C., Lindley, M. R., Ferguson, R. A., Constantin, D., Singh, S. J., Bolton, C. E., …Steiner, M. C. (2021). Submaximal Eccentric Cycling in People With COPD: Acute Whole-Body Cardiopulmonary and Muscle Metabolic Responses. Chest, 159(2), 564-574. https://doi.org/10.1016/j.chest.2020.08.2082

© 2020 American College of Chest Physicians Background: Eccentric cycling (ECC) may be an attractive exercise method in COPD because of both low cardiorespiratory demand and perception of effort compared with conventional concentric cycling (CON) at... Read More about Submaximal Eccentric Cycling in People With COPD: Acute Whole-Body Cardiopulmonary and Muscle Metabolic Responses.

Hyperpolarised xenon MRI and time-resolved X-ray computed tomography studies of structure-transport relationships in hierarchical porous media (2020)
Journal Article
Hill-Casey, F., Hotchkiss, T., Hardstone, K. A., Hitchcock, I., Novak, V., Schlepütz, C. M., …Rigby, S. P. (2021). Hyperpolarised xenon MRI and time-resolved X-ray computed tomography studies of structure-transport relationships in hierarchical porous media. Chemical Engineering Journal, 405, Article 126750. https://doi.org/10.1016/j.cej.2020.126750

© 2020 Elsevier B.V. Catalysed diesel particulate filter (DPF) monoliths are hierarchical porous solids, as demonstrated by mercury porosimetry. Establishing structure-transport relationships, including assessing the general accessibility of the cata... Read More about Hyperpolarised xenon MRI and time-resolved X-ray computed tomography studies of structure-transport relationships in hierarchical porous media.

Inflammatory responses to acute exercise during pulmonary rehabilitation in patients with COPD (2020)
Journal Article
Jenkins, A. R., Holden, N. S., & Jones, A. W. (2020). Inflammatory responses to acute exercise during pulmonary rehabilitation in patients with COPD. European Journal of Applied Physiology, 120(10), 2301-2309. https://doi.org/10.1007/s00421-020-04452-z

Objective
Pulmonary rehabilitation is a cornerstone treatment in the management of chronic obstructive pulmonary disease (COPD). Acute bouts of exercise can lead to short bursts of inflammation in healthy individuals. However, it is unclear how COPD... Read More about Inflammatory responses to acute exercise during pulmonary rehabilitation in patients with COPD.