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Outputs (18)

Haemphagocytic Lymphohistiocytosis in an English Nationwide Cohort Confirms Increasing Incidence and Variation in Trigger Factors (2022)
Presentation / Conference Contribution
Bishton, M., Crooks, C., Liu, H., Ban, L., Bythell, M., Card, T., Lanyon, P., Nanduri, V., Rankin, J., Stilwell, P., & West, J. Haemphagocytic Lymphohistiocytosis in an English Nationwide Cohort Confirms Increasing Incidence and Variation in Trigger Factors

Background: Haemophagocytic Lymphohistiocytosis (HLH) is a rare, life-threatening hyper-inflammatory syndrome triggered by constitutive and acquired risk factors including haematological malignancy, infection, auto-immunity and rheumatological diseas... Read More about Haemphagocytic Lymphohistiocytosis in an English Nationwide Cohort Confirms Increasing Incidence and Variation in Trigger Factors.

Process evaluation of a university residence-based SARS-CoV-2 testing programme in the UK (2022)
Presentation / Conference Contribution
Blake, H., Carlisle, S., Fothergill, L., Hassard, J., Favier, A., Corner, J., Ball, J., & Denning, C. Process evaluation of a university residence-based SARS-CoV-2 testing programme in the UK. Presented at 15th European Public Health Conference 2022, Berlin, Germany

Background Regular testing for SARS-CoV-2 is an important strategy for controlling virus outbreaks on university campuses during the COVID-19 pandemic but testing participation can be low. The Residence-Based Testing Participation Pilot (RB-TPP) was... Read More about Process evaluation of a university residence-based SARS-CoV-2 testing programme in the UK.

Impacts of the COVID-19 Pandemic and Self-Isolation on Students and Staff in Higher Education: A Qualitative Study (2022)
Presentation / Conference Contribution
Knight, H., Carlisle, S., O’Conna, M., Briggs, L., Fothergill, L., Al-Oraibi, A., Yildirim, M., Morling, J. R., Corner, J., Ball, J., Denning, C., Vedhara, K., & Blake, H. (2022, March). Impacts of the COVID-19 Pandemic and Self-Isolation on Students and Staff in Higher Education: A Qualitative Study. Presented at Midlands Academy of Medical Sciences Research Festival, Nottingham

High tissue inhibitor of matrix-metalloproteinase 2 expression correlates with poor prognosis in breast cancer (2020)
Presentation / Conference Contribution
Heyman, T., Joseph, C., Craze, M., Green, A., Nolan, C., Rueda, O., Provenzano, E., Rakha, E., Ellis, I. O., & Mukherjee, A. (2020, December). High tissue inhibitor of matrix-metalloproteinase 2 expression correlates with poor prognosis in breast cancer. Presented at 32nd Congress of the ESP and XXXIII International Congress of the IAP, Glasgow, UK (virtual)

Background & objectives
TIMP2, tissue inhibitor of matrix-metalloproteinase 2, inhibits the matrix-metalloproteinase, MMP2, but may activate pro-MMP2. Hence its correlation with prognosis in breast cancer (BC) is contradictory. This study investigat... Read More about High tissue inhibitor of matrix-metalloproteinase 2 expression correlates with poor prognosis in breast cancer.

Epen-23. A computational analysis of the tumour immune microenvironment in paediatric ependymoma (2020)
Presentation / Conference Contribution
Ritzmann, T., Lourdusamy, A., Jackson, A., Storer, L., Donson, A., Griesinger, A., Foreman, N., Rogers, H., & Grundy, R. Epen-23. A computational analysis of the tumour immune microenvironment in paediatric ependymoma

Ependymoma is the third commonest childhood brain tumour. Relapse is frequent, often fatal and current therapeutic strategies are inadequate. Previous ependymoma research describes an immunosuppressive environment with T-cell exhaustion, indicating a... Read More about Epen-23. A computational analysis of the tumour immune microenvironment in paediatric ependymoma.

Epen-22. Single-cell RNA sequencing identifies upregulation of IKZF1 in PFA2 myeloid subpopulation driving an anti-tumor phenotype (2020)
Presentation / Conference Contribution
Griesinger, A., Prince, E., Donson, A., Riemondy, K., Ritzman, T., Harris, F., Amani, V., Handler, M., Hankinson, T., Grundy, R., Jackson, A., & Foreman, N. Epen-22. Single-cell RNA sequencing identifies upregulation of IKZF1 in PFA2 myeloid subpopulation driving an anti-tumor phenotype

We have previously shown immune gene phenotype variations between posterior fossa ependymoma subgroups. PFA1 tumors chronically secrete IL-6, which pushes the infiltrating myeloid cells to an immune suppressive function. In contrast, PFA2 tumors have... Read More about Epen-22. Single-cell RNA sequencing identifies upregulation of IKZF1 in PFA2 myeloid subpopulation driving an anti-tumor phenotype.

IgG4 Expression Correlates with Poor Prognosis in Pancreatic Adenocarcinoma (2019)
Presentation / Conference Contribution
Budd, W., Mukherjee, A., Lobo, D., & Zaitoun, A. (2019, July). IgG4 Expression Correlates with Poor Prognosis in Pancreatic Adenocarcinoma. Presented at Leeds Pathology 2019. 12th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 2–4 July 2019, Leeds, England

Purpose of the study: IgG4, a member of the immunoglobulin family, has been implicated in the pathobiology of inflammatory disease (including autoimmune pancreatitis) and cancers. Its role in pancreatic cancers however remains to be elucidated. This... Read More about IgG4 Expression Correlates with Poor Prognosis in Pancreatic Adenocarcinoma.

Cell division cycle 25C (CDC25C) expression confers poor prognosis in invasive breast cancer (2017)
Presentation / Conference Contribution
Ojiegbe, S., Joseph, C., Provenzano, E., Caldas, C., Nolan, C., Green, A., Rakha, E., Ellis, I., & Mukherjee, A. Cell division cycle 25C (CDC25C) expression confers poor prognosis in invasive breast cancer. Presented at Belfast Pathology 2017: 10th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland

Background: CDC25C, belonging to the Cdc25 phosphatase family, plays a major role in cell cycle control, impacting on DNA repair and apoptosis. It has been shown that poor prognosis/copy number high Luminal A breast cancers (BCs) are enriched for the... Read More about Cell division cycle 25C (CDC25C) expression confers poor prognosis in invasive breast cancer.

Loss of MED23 leads to poor prognosis in invasive breast cancer (2017)
Presentation / Conference Contribution
cancer. Presented at Belfast Pathology 2017: 10th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland

Purpose of the study: The molecular mechanism of lymphovascular invasion (LVI) which determines the early metastatic phenotype in breast cancer is still not fully understood. Lead from the METABRIC study revealed that MED23 correlated with negative L... Read More about Loss of MED23 leads to poor prognosis in invasive breast cancer.