Outputs (4)

TGFβ1-induced cell motility but not cell proliferation is mediated through Cten in colorectal cancer (2018)
Journal Article
Asiri, A., Raposo, T. P., Alfahed, A., & Ilyas, M. (2018). TGFβ1-induced cell motility but not cell proliferation is mediated through Cten in colorectal cancer. International Journal of Experimental Pathology, 99(6), 323-330. https://doi.org/10.1111/iep.12300

Cten (C-terminal tensin-like) is a member of the tensin protein family found in complex with integrins at focal adhesions. It promotes epithelial‐mesenchymal transition (EMT) and cell motility. The precise mechanisms regulating Cten are unknown, alth... Read More about TGFβ1-induced cell motility but not cell proliferation is mediated through Cten in colorectal cancer.

FLYWCH1, a novel suppressor of nuclear b-catenin, regulates migration and morphology in colorectal cancer (2018)
Journal Article
Muhammad, B. A., Almozyan, S., Babaei-Jadidi, R., Onyido, E. K., Saadeddin, A., Kashfi, S. H., …Nateri, A. S. (2018). FLYWCH1, a novel suppressor of nuclear b-catenin, regulates migration and morphology in colorectal cancer. Molecular Cancer Research, 16(12), 1977-1990. https://doi.org/10.1158/1541-7786.MCR-18-0262

© 2018 American Association for Cancer Research. Wnt/b-catenin signaling plays a critical role during development of both normal and malignant colorectal cancer tissues. Phosphorylation of b-catenin protein alters its trafficking and function. Such c... Read More about FLYWCH1, a novel suppressor of nuclear b-catenin, regulates migration and morphology in colorectal cancer.

CD10 inhibits cell motility but expression is associated with advanced stage disease in colorectal cancer (2018)
Journal Article
Raposo, T., Comes, M. S., Idowu, A., Agit, B., Hassall, J., Fadhil, W., Nica, R., Ecker, R., Yao, T., & Ilyas, M. (2018). CD10 inhibits cell motility but expression is associated with advanced stage disease in colorectal cancer. Experimental and Molecular Pathology, 104(3), https://doi.org/10.1016/j.yexmp.2018.04.002

Introduction
CD10 is a cell membrane-bound endopeptidase which is expressed in normal small bowel but not in normal colon. It is aberrantly expressed in a small proportion of colorectal cancers (CRC) and this has been associated with liver metastasi... Read More about CD10 inhibits cell motility but expression is associated with advanced stage disease in colorectal cancer.

N_LyST: a simple and rapid screening test for Lynch Syndrome (2018)
Journal Article
Susanti, S., Fadhil, W., Ebili, H. O., Asiri, A., Nestarenkaite, A., Hadjimichael, E., Ham-Karim, H. A., Field, J., Stafford, K., Matharoo-Ball, B., Hassall, J. C., Sharif, A., Oniscu, A., & Ilyas, M. (2018). N_LyST: a simple and rapid screening test for Lynch Syndrome. Journal of Clinical Pathology, 71(8), 713-720. https://doi.org/10.1136/jclinpath-2018-205013

Aims: We sought to use PCR followed by high-resolution melting (HRM) analysis to develop a single closed-tube screening panel to screen for Lynch Syndrome. This comprises tests for microsatellite instability (MSI), MLH1 methylation promoter and BRAF... Read More about N_LyST: a simple and rapid screening test for Lynch Syndrome.