Outputs (13)

Targeting hypoxia regulated sodium driven bicarbonate transporters reduces triple negative breast cancer metastasis (2022)
Journal Article
Harris, A. L., Clarke, P. A., Carroll, C. P., Bolland, H., Vancauwenberghe, E., Collier, P., …McIntyre, A. (2022). Targeting hypoxia regulated sodium driven bicarbonate transporters reduces triple negative breast cancer metastasis. Neoplasia, 25, 41-52. https://doi.org/10.1016/j.neo.2022.01.003

Regions of low oxygen (hypoxia) are found in >50% of breast tumours, most frequently in the more aggressive triple negative breast cancer subtype (TNBC). Metastasis is the cause of 90% of breast cancer patient deaths. Regions of tumour hypoxia tend t... Read More about Targeting hypoxia regulated sodium driven bicarbonate transporters reduces triple negative breast cancer metastasis.

Intratumour heterogeneity in microRNAs expression regulates glioblastoma metabolism (2021)
Journal Article
Alfardus, H., de los Angeles Estevez Cebrero, M., Rowlinson, J., Lourdusamy, A., Abdelrazig, S., Ortori, C., …Smith, S. (2021). Intratumour heterogeneity in microRNAs expression regulates glioblastoma metabolism. Scientific Reports, 11(1), Article 15908. https://doi.org/10.1038/s41598-021-95289-9

While specific microRNA (miRNA) signatures have been identified in glioblastoma (GBM), the intratumour heterogeneity in miRNA expression has not yet been characterised. In this study, we reveal significant alterations in miRNA expression across three... Read More about Intratumour heterogeneity in microRNAs expression regulates glioblastoma metabolism.

Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS (2020)
Journal Article
Wu, X., Niculite, C. M., Bogdan Preda, M., Rossi, A., Tebaldi, T., Butoi, E., …Ivan, M. (2020). Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS. Nature Communications, 11, Article 4755. https://doi.org/10.1038/s41467-020-18411-x

We hereby provide the initial portrait of lincNORS, a spliced lincRNA generated by the MIR193BHG locus, entirely distinct from the previously described miR-193b-365a tandem. While inducible by low O2 in a variety of cells and associated with hypoxia... Read More about Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS.

Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer (2019)
Journal Article
Morotti, M., Bridges, E., Valli, A., Choudhry, H., Sheldon, H., Wigfield, S., …Harris, A. L. (2019). Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer. Proceedings of the National Academy of Sciences, 116(25), 12452-12461. https://doi.org/10.1073/pnas.1818521116

Tumor hypoxia is associated with poor patient outcomes in estrogen receptor-α–positive (ERα+) breast cancer. Hypoxia is known to affect tumor growth by reprogramming metabolism and regulating amino acid (AA) uptake. Here, we show that the glutamine t... Read More about Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer.

Adaptation to HIF1a deletion in hypoxic cancer cells by upregulation of GLUT14 and creatine metabolism (2019)
Journal Article
Valli, A., Morotti, M., Zois, C. E., Albers, P. K., Soga, T., Feldinger, K., …Harris, A. L. (2019). Adaptation to HIF1a deletion in hypoxic cancer cells by upregulation of GLUT14 and creatine metabolism. Molecular Cancer Research, 17(7), 1531-1544. https://doi.org/10.1158/1541-7786.MCR-18-0315

© 2019 American Association for Cancer Research. Hypoxia-inducible factor 1a is a key regulator of the hypoxia response in normal and cancer tissues. It is well recognized to regulate glycolysis and is a target for therapy. However, how tumor cells a... Read More about Adaptation to HIF1a deletion in hypoxic cancer cells by upregulation of GLUT14 and creatine metabolism.

Altered glutamine metabolism in breast cancer: subtype dependencies and alternative adaptations (2017)
Journal Article
El Ansari, R., McIntyre, A., Craze, M. L., Ellis, I. O., Rakha, E. A., & Green, A. R. (in press). Altered glutamine metabolism in breast cancer: subtype dependencies and alternative adaptations. Histopathology, https://doi.org/10.1111/his.13334

Cancer cells must alter their metabolism in order to satisfy the demands of necessary energy and cellular building blocks. These metabolic alterations are mediated by many oncogenic changes that affect cellular signalling pathways, which result in su... Read More about Altered glutamine metabolism in breast cancer: subtype dependencies and alternative adaptations.

MicroRNA regulation of glycolytic metabolism in glioblastoma multiforme (2017)
Journal Article
Alfardus, H., McIntyre, A., & Smith, S. J. (2017). MicroRNA regulation of glycolytic metabolism in glioblastoma multiforme. BioMed Research International, 2017, https://doi.org/10.1155/2017/9157370

Glioblastoma multiforme (GBM) is the most aggressive and common malignant brain and central nervous system tumour. A well-known hallmark of GMB, and many other tumours, is aerobic glycolysis. microRNAs (miRNAs) are a class of short non-protein coding... Read More about MicroRNA regulation of glycolytic metabolism in glioblastoma multiforme.

Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia (2016)
Journal Article
Haider, S., MCINTYRE, A., van Stiphout, R. G., Winchester, L. M., Wigfield, S., Harris, A. L., & Buffa, F. M. (2016). Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia. Genome Biology, 17(1), Article 140. https://doi.org/10.1186/s13059-016-0999-8

The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer (2016)
Journal Article
da Motta, L. L., Ledaki, I., Purshouse, K., Haider, S., de Bastiani, M., Baban, D., Morotti, M., Steers, G., Wigfield, S., Bridges, E., Li, J.-L., Knapp, S., Ebner, D., Klamt, F., Harris, A. L., & McIntyre, A. (2017). The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer. Oncogene, 36, 122-132. https://doi.org/10.1038/onc.2016.184

The availability of bromodomain and extra-terminal inhibitors (BETi) has enabled translational epigenetic studies in cancer. BET proteins regulate transcription by selectively recognizing acetylated lysine residues on chromatin. BETi compete with thi... Read More about The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer.

Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth (2016)
Journal Article

Tumor hypoxia is associated clinically with therapeutic resistance and poor patient outcomes. One feature of tumor hypoxia is activated expression of carbonic anhydrase IX (CA9), a regulator of pH and tumor growth. In this study, we investigated the... Read More about Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth.