Outputs (156)

Rates, risks and routes to reduce vascular dementia (R4vad), a UK-wide multicentre prospective observational cohort study of cognition after stroke: Protocol (2020)
Journal Article
Wardlaw, J. M., Doubal, F., Brown, R., Backhouse, E., Woodhouse, L., Bath, P., …R4VaD Investigators. (2021). Rates, risks and routes to reduce vascular dementia (R4vad), a UK-wide multicentre prospective observational cohort study of cognition after stroke: Protocol. European Stroke Journal, 6(1), 89-101. https://doi.org/10.1177/2396987320953312

Background: Stroke commonly affects cognition and, by definition, much vascular dementia follows stroke. However, there are fundamental limitations in our understanding of vascular cognitive impairment, restricting understanding of prevalence, trajec... Read More about Rates, risks and routes to reduce vascular dementia (R4vad), a UK-wide multicentre prospective observational cohort study of cognition after stroke: Protocol.

Uncertainty modelling in deep learning for safer neuroimage enhancement: Demonstration in diffusion MRI (2020)
Journal Article
Tanno, R., Worrall, D. E., Kaden, E., Ghosh, A., Grussu, F., Bizzi, A., …Alexander, D. C. (2021). Uncertainty modelling in deep learning for safer neuroimage enhancement: Demonstration in diffusion MRI. NeuroImage, 225, Article 117366. https://doi.org/10.1016/j.neuroimage.2020.117366

Deep learning (DL) has shown great potential in medical image enhancement problems, such as super-resolution or image synthesis. However, to date, most existing approaches are based on deterministic models, neglecting the presence of different source... Read More about Uncertainty modelling in deep learning for safer neuroimage enhancement: Demonstration in diffusion MRI.

Bimodal neuromodulation combining sound and tongue stimulation reduces tinnitus symptoms in a large randomized clinical study (2020)
Journal Article
Conlon, B., Langguth, B., Hamilton, C., Hughes, S., Meade, E., Connor, C. O., …Lim, H. H. (2020). Bimodal neuromodulation combining sound and tongue stimulation reduces tinnitus symptoms in a large randomized clinical study. Science Translational Medicine, 12(564), Article eabb2830. https://doi.org/10.1126/scitranslmed.abb2830

Tinnitus is a phantom auditory perception coded in the brain that can be bothersome or debilitating, affecting 10 to 15% of the population. Currently, there is no clinically recommended drug or device treatment for this major health condition. Animal... Read More about Bimodal neuromodulation combining sound and tongue stimulation reduces tinnitus symptoms in a large randomized clinical study.

Clinical management of cerebral small vessel disease: a call for a holistic approach (2020)
Journal Article
Clancy, U., Appleton, J. P., Arteaga, C., Doubal, F. N., Bath, P. M., & Wardlaw, J. M. (2021). Clinical management of cerebral small vessel disease: a call for a holistic approach. Chinese Medical Journal, 134(2), 127-142. https://doi.org/10.1097/cm9.0000000000001177

Cerebral small vessel disease (SVD) is a common global brain disease that causes cognitive impairment, ischemic or hemorrhagic stroke, problems with mobility, and neuropsychiatric symptoms. The brain damage, seen as focal white and deep grey matter l... Read More about Clinical management of cerebral small vessel disease: a call for a holistic approach.

Comparative effects of intensive-versus standard-BP lowering treatment in patients with severe ischemic stroke in the ENCHANTED trial (2020)
Journal Article
Minhas, J. S., Wang, X., Lindley, R. I., Delcourt, C., Song, L., Woodward, M., …Robinson, T. G. (2021). Comparative effects of intensive-versus standard-BP lowering treatment in patients with severe ischemic stroke in the ENCHANTED trial. Journal of Hypertension, 39(2), 280-285. https://doi.org/10.1097/hjh.0000000000002640

Objective: Limited data exist on the optimum level of systolic blood pressure (BP) in thrombolyzed patients with acute ischemic stroke (AIS). We aimed to determine the effects of intensive BP lowering, specifically in patients with severe AIS who par... Read More about Comparative effects of intensive-versus standard-BP lowering treatment in patients with severe ischemic stroke in the ENCHANTED trial.

Developing a clinical pathway to identify and manage cognitive problems in Multiple Sclerosis: Qualitative findings from patients, family members, charity volunteers, clinicians and healthcare commissioners (2020)
Journal Article
Smith, L., Elwick, H., Mhizha-Murira, J., Topcu, G., Bale, C., Evangelou, N., …Das Nair, R. (2021). Developing a clinical pathway to identify and manage cognitive problems in Multiple Sclerosis: Qualitative findings from patients, family members, charity volunteers, clinicians and healthcare commissioners. Multiple Sclerosis and Related Disorders, 49, Article 102563. https://doi.org/10.1016/j.msard.2020.102563

Background: Cognitive problems are a common and debilitating symptom of multiple sclerosis (MS). Screening and treatment for cognitive problems are recommended, however these are not routinely delivered in UK clinics.

We collected and synthesised... Read More about Developing a clinical pathway to identify and manage cognitive problems in Multiple Sclerosis: Qualitative findings from patients, family members, charity volunteers, clinicians and healthcare commissioners.

Tinnitus and stress in adults: a scoping review (2020)
Journal Article
Elarbed, A., Fackrell, K., Baguley, D. M., & Hoare, D. J. (2021). Tinnitus and stress in adults: a scoping review. International Journal of Audiology, 60(3), 171-182. https://doi.org/10.1080/14992027.2020.1827306

Objective
Tinnitus and stress are recurrently reported together. The strength and direction of this relationship is not clear. The aim of this review is to catalogue the evidence of this relationship, how it has been described in adults and which in... Read More about Tinnitus and stress in adults: a scoping review.

A scoping review of psychoeducational interventions for people after transient ischemic attack and minor stroke (2020)
Journal Article
Kontou, E., Kettlewell, J., Condon, L., Thomas, S., Lee, A. R., Sprigg, N., …Shokraneh, F. (2021). A scoping review of psychoeducational interventions for people after transient ischemic attack and minor stroke. Topics in Stroke Rehabilitation, 28(5), 390-400. https://doi.org/10.1080/10749357.2020.1818473

Background: Psychoeducation can provide information and support to cope with the physical and emotional effects of a health condition. This scoping review aimed to identify the evidence regarding psychoeducational interventions for people after a Tra... Read More about A scoping review of psychoeducational interventions for people after transient ischemic attack and minor stroke.

Antiplatelet Therapy for Transient Ischemic Attack and Minor Stroke (2020)
Journal Article
Xiong, Y., & Bath, P. (2020). Antiplatelet Therapy for Transient Ischemic Attack and Minor Stroke. Stroke, 51(11), 3472-3474. https://doi.org/10.1161/STROKEAHA.120.031763

Remote platelet function testing using P-selectin expression in patients with recent cerebral ischaemia on clopidogrel (2020)
Journal Article
Appleton, J. P., Richardson, C., Dovlatova, N., May, J., Sprigg, N., Heptinstall, S., & Bath, P. M. (2021). Remote platelet function testing using P-selectin expression in patients with recent cerebral ischaemia on clopidogrel. Stroke and Vascular Neurology, 6(1), 103-108. https://doi.org/10.1136/svn-2020-000346

Background Antiplatelet agents reduce recurrence after cerebral ischaemia but are not effective in all patients, in part because of treatment resistance. The primary aim was to assess the proportion of patients who are insensitive to clopidogrel. The... Read More about Remote platelet function testing using P-selectin expression in patients with recent cerebral ischaemia on clopidogrel.