Outputs (133)

Corneal nerves in health and disease (2019)
Journal Article
Al Aqaba, M. A., Dhillon, V. K., Mohammed, I., Said, D. G., & Dua, H. S. (2019). Corneal nerves in health and disease. Progress in Retinal and Eye Research, 73, Article 100762. https://doi.org/10.1016/j.preteyeres.2019.05.003

The cornea is the most sensitive structure in the human body. Corneal nerves adapt to maintain transparency and contribute to corneal health by mediating tear secretion and protective reflexes and provide trophic support to epithelial and stromal cel... Read More about Corneal nerves in health and disease.

Relationship between neuromelanin and dopamine terminals within the Parkinson’s nigrostriatal system (2019)
Journal Article
Martín-Bastida, A., Lao-Kaim, N. P., Roussakis, A. A., Searle, G. E., Xing, Y., Gunn, R. N., …Piccini, P. (2019). Relationship between neuromelanin and dopamine terminals within the Parkinson’s nigrostriatal system. Brain, 142(7), 2023–2036. https://doi.org/10.1093/brain/awz120

© 2019 The Author(s). All rights reserved. Parkinson's disease is characterized by the progressive loss of pigmented dopaminergic neurons in the substantia nigra and associated striatal deafferentation. Neuromelanin content is thought to reflect the... Read More about Relationship between neuromelanin and dopamine terminals within the Parkinson’s nigrostriatal system.

Determining the sample size for future trials of hearing instruments for unilaterally deaf adults: an application of network meta-analysis (2019)
Journal Article
Gaunt, A. C., & Kitterick, P. T. (2019). Determining the sample size for future trials of hearing instruments for unilaterally deaf adults: an application of network meta-analysis. Otology and Neurotology, 40(4), e342–e348. https://doi.org/10.1097/MAO.0000000000002186

Objective: Previous trials have compared the efficacy of hearing instruments to no intervention in adults with single- sided deafness (SSD) or the relative efficacy of different instruments. Network meta-analysis (NMA) was used to refine estimates of... Read More about Determining the sample size for future trials of hearing instruments for unilaterally deaf adults: an application of network meta-analysis.

How do we know that our patients have benefitted from our ENT/Audiological interventions?: presented at the Annual Meeting of ADANO 2016 in Berlin (2019)
Journal Article
Hall, D. A., Kitterick, P. T., Heffernan, E., Fackrell, K., Lucas, L., & Ferguson, M. (2019). How do we know that our patients have benefitted from our ENT/Audiological interventions?: presented at the Annual Meeting of ADANO 2016 in Berlin. Otology and Neurotology, 40(4), e474-e481. https://doi.org/10.1097/MAO.0000000000001937

This short review article gives an introduction to some of the fundamental concepts and challenges facing measurement in hearing healthcare practice and research. The impact of hearing loss almost always extends beyond the sensory impairment itself,... Read More about How do we know that our patients have benefitted from our ENT/Audiological interventions?: presented at the Annual Meeting of ADANO 2016 in Berlin.

Quantifying T2 relaxation time changes within lesions defined by apparent diffusion coefficient in grey and white matter in acute stroke patients (2019)
Journal Article
Damion, R. A., Knight, M. J., McGarry, B. L., Bosnell, R., Jezzard, P., Harston, G. W., …Kauppinen, R. A. (2019). Quantifying T2 relaxation time changes within lesions defined by apparent diffusion coefficient in grey and white matter in acute stroke patients. Physics in Medicine and Biology, 64(9), Article 095016. https://doi.org/10.1088/1361-6560/ab1442

The apparent diffusion coefficient (ADC) of cerebral water, as measured by diffusion MRI, rapidly decreases in ischaemia, highlighting a lesion in acute stroke patients. The MRI T2 relaxation time changes in ischaemic brain such that T2 in ADC lesion... Read More about Quantifying T2 relaxation time changes within lesions defined by apparent diffusion coefficient in grey and white matter in acute stroke patients.

Hearing impairment and daily-life fatigue: a qualitative study (2019)
Journal Article
Holman, J. A., Drummond, A., Hughes, S. E., & Naylor, G. (2019). Hearing impairment and daily-life fatigue: a qualitative study. International Journal of Audiology, 58(7), 408-416. https://doi.org/10.1080/14992027.2019.1597284

Objective: Hearing impairment is linked to increased fatigue, yet little is known about the real-world impact of this fatigue. This qualitative study investigated the experience of daily-life fatigue in people with a hearing impairment.
Design: Ind... Read More about Hearing impairment and daily-life fatigue: a qualitative study.

Content validity and readability of patient-reported questionnaire instruments of hearing disability (2019)
Journal Article
Manchaiah, V., Granberg, S., Grover, V., Saunders, G., & Hall, D. (2019). Content validity and readability of patient-reported questionnaire instruments of hearing disability. International Journal of Audiology, 58(9), 565-575. https://doi.org/10.1080/14992027.2019.1602738

Objective: The current study evaluates the content validity (i.e., domains assessed) and readability levels of patient-reported questionnaire instruments using internationally recognized
procedures and tools.

Design: A review of the literature to... Read More about Content validity and readability of patient-reported questionnaire instruments of hearing disability.

Tolerability, safety and intermediary pharmacological effects of cilostazol and isosorbide mononitrate, alone and combined, in patients with lacunar ischaemic stroke: the LACunar Intervention-1 (LACI-1) trial, a randomised clinical trial (2019)
Journal Article
Blair, G. W., Appleton, J. P., Flaherty, K., Doubal, F., Sprigg, N., Dooley, R., …Wardlaw, J. M. (2019). Tolerability, safety and intermediary pharmacological effects of cilostazol and isosorbide mononitrate, alone and combined, in patients with lacunar ischaemic stroke: the LACunar Intervention-1 (LACI-1) trial, a randomised clinical trial. eClinicalMedicine, 11, 34-43. https://doi.org/10.1016/j.eclinm.2019.04.001

Background
Lacunar stroke, a frequent clinical manifestation of small vessel disease (SVD), differs pathologically from other ischaemic stroke subtypes and has no specific long-term secondary prevention. Licenced drugs, isosorbide mononitrate (ISMN)... Read More about Tolerability, safety and intermediary pharmacological effects of cilostazol and isosorbide mononitrate, alone and combined, in patients with lacunar ischaemic stroke: the LACunar Intervention-1 (LACI-1) trial, a randomised clinical trial.

Factors related to insomnia in adult patients with tinnitus and/or hyperacusis: an exploratory analysis (2019)
Journal Article
Aazh, H., Baguley, D. M., & Moore, B. C. (2019). Factors related to insomnia in adult patients with tinnitus and/or hyperacusis: an exploratory analysis. Journal of the American Academy of Audiology, 30(9), 802-809. https://doi.org/10.3766/jaaa.18020

Background: People with tinnitus and/or hyperacusis often experience insomnia. However, it is unclear what factors are most strongly associated with insomnia. Purpose: To explore factors related to insomnia in patients with tinnitus and/or hyperacusi... Read More about Factors related to insomnia in adult patients with tinnitus and/or hyperacusis: an exploratory analysis.

Therapeutic hypothermia for acute ischaemic stroke. Results of a European multicentre, randomised, phase III clinical trial (2019)
Journal Article
van der Worp, H. B., Macleod, M. R., Bath, P. M., Bathula, R., Christensen, H., Colam, B., …the EuroHYP-1 investigators. (2019). Therapeutic hypothermia for acute ischaemic stroke. Results of a European multicentre, randomised, phase III clinical trial. European Stroke Journal, 4(3), 254-262. https://doi.org/10.1177/2396987319844690

© European Stroke Organisation 2019. Introduction: We assessed whether modest systemic cooling started within 6 hours of symptom onset improves functional outcome at three months in awake patients with acute ischaemic stroke. Patients and methods: In... Read More about Therapeutic hypothermia for acute ischaemic stroke. Results of a European multicentre, randomised, phase III clinical trial.