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Outputs (33)

Host Defence Peptides: A Potent Alternative to Combat Antimicrobial Resistance in the Era of the COVID-19 Pandemic (2022)
Journal Article
Ali, W., Elsahn, A., Ting, D. S. J., Dua, H. S., & Mohammed, I. (2022). Host Defence Peptides: A Potent Alternative to Combat Antimicrobial Resistance in the Era of the COVID-19 Pandemic. Antibiotics, 11(4), Article 475. https://doi.org/10.3390/antibiotics11040475

One of the greatest challenges facing the medical community today is the ever-increasing trajectory of antimicrobial resistance (AMR), which is being compounded by the decrease in our antimicrobial armamentarium. From their initial discovery to the c... Read More about Host Defence Peptides: A Potent Alternative to Combat Antimicrobial Resistance in the Era of the COVID-19 Pandemic.

Clinical Characteristics and Outcomes of Fungal Keratitis in the United Kingdom 2011–2020: A 10-Year Study (2021)
Journal Article
Ting, D. S. J., Galal, M., Kulkarni, B., Elalfy, M. S., Lake, D., Hamada, S., …Dua, H. S. (2021). Clinical Characteristics and Outcomes of Fungal Keratitis in the United Kingdom 2011–2020: A 10-Year Study. Journal of Fungi, 7(11), Article 966. https://doi.org/10.3390/jof7110966

Fungal keratitis (FK) is a serious ocular infection that often poses significant diagnostic and therapeutic dilemmas. This study aimed to examine the causes, clinical characteristics, out-comes, and prognostic factors of FK in the UK. All culture-pos... Read More about Clinical Characteristics and Outcomes of Fungal Keratitis in the United Kingdom 2011–2020: A 10-Year Study.

Post-keratoplasty Infectious Keratitis: Epidemiology, Risk Factors, Management, and Outcomes (2021)
Journal Article
Song, A., Deshmukh, R., Lin, H., Ang, M., Mehta, J. S., Chodosh, J., …Ting, D. S. (2021). Post-keratoplasty Infectious Keratitis: Epidemiology, Risk Factors, Management, and Outcomes. Frontiers in Medicine, 8, Article 707242. https://doi.org/10.3389/fmed.2021.707242

Post-keratoplasty infectious keratitis (PKIK) represents a unique clinical entity that often poses significant diagnostic and therapeutic challenges. It carries a high risk of serious complications such as graft rejection and failure, and less common... Read More about Post-keratoplasty Infectious Keratitis: Epidemiology, Risk Factors, Management, and Outcomes.

Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance (2021)
Journal Article
Ting, D. S. J., Ho, C. S., Deshmukh, R., Said, D. G., & Dua, H. S. (2021). Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance. Eye, 35, 1084-1101. https://doi.org/10.1038/s41433-020-01339-3

Corneal opacity is the 5th leading cause of blindness and visual impairment globally, affecting ~6 million of the world population. In addition, it is responsible for 1.5–2.0 million new cases of monocular blindness per year, highlighting an ongoing... Read More about Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance.

Seasonal patterns of incidence, demographic factors and microbiological profiles of infectious keratitis: the Nottingham Infectious Keratitis Study (2020)
Journal Article
Ting, D. S. J., Ho, C. S., Cairns, J., Gopal, B. P., Elsahn, A., Al-Aqaba, M., …Dua, H. S. (2021). Seasonal patterns of incidence, demographic factors and microbiological profiles of infectious keratitis: the Nottingham Infectious Keratitis Study. Eye, 35(9), 2543-2549. https://doi.org/10.1038/s41433-020-01272-5

Purpose: The purpose of this study is to examine the seasonal patterns of incidence, demographic factors and microbiological profiles of infectious keratitis (IK) in Nottingham, UK. Methods: A retrospective study of all patients who were diagnosed wi... Read More about Seasonal patterns of incidence, demographic factors and microbiological profiles of infectious keratitis: the Nottingham Infectious Keratitis Study.

Antimicrobial peptides in human corneal tissue of patients with fungal keratitis (2020)
Journal Article
Mohammed, I., Mohanty, D., Said, D. G., Barik, M. R., Reddy, M. M., Alsaadi, A., …Mittal, R. (2021). Antimicrobial peptides in human corneal tissue of patients with fungal keratitis. British Journal of Ophthalmology, 105(8), 1172-1177. https://doi.org/10.1136/bjophthalmol-2020-316329

Background Fungal keratitis (FK) is the leading cause of unilateral blindness in the developing world. Antimicrobial peptides (AMPs) have been shown to play an important role on human ocular surface (OS) during bacterial, viral and protozoan infectio... Read More about Antimicrobial peptides in human corneal tissue of patients with fungal keratitis.

Management of primary pterygium with intra-lesional injection of 5 flurouracil and bevacizumab (Avastin) (2019)
Journal Article
Ghoz, N., Britton, J., Ross, A. R., Mohammed, I., Hogan, E., Said, D. G., & Dua, H. S. (2019). Management of primary pterygium with intra-lesional injection of 5 flurouracil and bevacizumab (Avastin). Eye, 33(11), 1776-1783. https://doi.org/10.1038/s41433-019-0493-0

Background

To assess the efficacy of combined 5FU and Avastin injections in the treatment of primary pterygium

Methods

Sixteen eyes with primary pterygium received intralesional 5 fluorouracil and Avastin (2.5–5 mg) injections every 2 weeks... Read More about Management of primary pterygium with intra-lesional injection of 5 flurouracil and bevacizumab (Avastin).

In vitro evaluation of electrospun blends of gelatin and PCL for application as a partial thickness corneal graft (2018)
Journal Article
Rose, J., Sidney, L., Patient, J., White, L., Dua, H., El Haj, A., …Rose, F. (2018). In vitro evaluation of electrospun blends of gelatin and PCL for application as a partial thickness corneal graft. Journal of Biomedical Materials Research Part A, 107(4), 828-838. https://doi.org/10.1002/jbm.a.36598

The advent of innovative surgical procedures utilizing partial thickness corneal grafts has created a need for the development of synthetic implants to recreate corneal stromal tissue. This work evaluates electrospun gelatin and polycaprolactone (PCL... Read More about In vitro evaluation of electrospun blends of gelatin and PCL for application as a partial thickness corneal graft.