Skip to main content

Research Repository

Advanced Search

Outputs (36)

Glutamine supplementation in cystic fibrosis: A randomized placebo-controlled trial: Oral Glutamine Supplementation in Cystic Fibrosis (2015)
Journal Article
Forrester, D. L., Knox, A. J., Smyth, A. R., Barr, H. L., Simms, R., Pacey, S. J., …Fogarty, A. W. (2016). Glutamine supplementation in cystic fibrosis: A randomized placebo-controlled trial: Oral Glutamine Supplementation in Cystic Fibrosis. Pediatric Pulmonology, 51(3), 253-257. https://doi.org/10.1002/ppul.23370

Rationale: Pulmonary infection and malnutrition in cystic fibrosis are associated with decreased survival. Glutamine has a possible anti-microbial effect, with a specific impact against Pseudomonas aeruginosa. We aimed to test the hypothesis that ora... Read More about Glutamine supplementation in cystic fibrosis: A randomized placebo-controlled trial: Oral Glutamine Supplementation in Cystic Fibrosis.

Cycling infrastructure for reducing cycling injuries in cyclists (2015)
Journal Article
Mulvaney, C. A., Smith, S., Watson, M. C., Parkin, J., Coupland, C., Miller, P., …McClintock, H. (2015). Cycling infrastructure for reducing cycling injuries in cyclists. Cochrane Database of Systematic Reviews, https://doi.org/10.1002/14651858.CD010415.pub2

Background: Cycling is an attractive form of transport. It is beneficial to the individual as a form of physical activity that may fit more readily into an individual’s daily routine, such as for cycling to work and to the shops, than other physical... Read More about Cycling infrastructure for reducing cycling injuries in cyclists.

Born from pre-eclamptic pregnancies predisposes infants to altered cortisol metabolism in the first postnatal year (2015)
Journal Article
Broughton Pipkin, F., Mistry, H. D., Roy, C., Dick, B., Waugh, J., Chikhi, R., Kurlak, L., & Mohaupt, M. (2015). Born from pre-eclamptic pregnancies predisposes infants to altered cortisol metabolism in the first postnatal year. Endocrine Connections, 4(4), https://doi.org/10.1530/EC-15-0084

Pre-eclampsia leads to disturbed fetal organ development, including metabolic syndrome, attributed to altered pituitary-adrenal feedback loop. We measured cortisol metabolites in infants born from pre-eclamptic and normotensive women and hypothesised... Read More about Born from pre-eclamptic pregnancies predisposes infants to altered cortisol metabolism in the first postnatal year.

Effect of oxygen on the expression of renin-angiotensin system components in a human trophoblast cell line (2015)
Journal Article
Delforce, S. J., Wang, Y., Van-Aalst, M. E., Corbisier de Meaultsart, C., Morris, B. J., Broughton Pipkin, F., …Pringle, K. G. (2016). Effect of oxygen on the expression of renin-angiotensin system components in a human trophoblast cell line. Placenta, 37, https://doi.org/10.1016/j.placenta.2015.11.011

During the first trimester, normal placental development occurs in a low oxygen environment that is known to stimulate angiogenesis via upregulation of vascular endothelial growth factor (VEGF). Expression of the placental renin-angiotensin system (R... Read More about Effect of oxygen on the expression of renin-angiotensin system components in a human trophoblast cell line.

Use of biochemical tests of placental function for improving pregnancy outcome (2015)
Journal Article
Heazell, A. E., Whitworth, M., Duley, L., & Thornton, J. (2015). Use of biochemical tests of placental function for improving pregnancy outcome. Cochrane Library, 2015(11), Article CD011202. https://doi.org/10.1002/14651858.CD011202.pub2

BACKGROUND:

The placenta has an essential role in determining the outcome of pregnancy. Consequently, biochemical measurement of placentally-derived factors has been suggested as a means to improve fetal and maternal outcome of pregnancy.


OBJ... Read More about Use of biochemical tests of placental function for improving pregnancy outcome.

Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis (2015)
Journal Article
Gilchrist, F. J., Belcher, J., Jones, A. M., Smith, D., Smyth, A. R., Southern, K. W., …Lenney, W. (2015). Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis. ERJ Open Research, 1(2), https://doi.org/10.1183/23120541.00044-2015

Hydrogen cyanide is readily detected in the headspace above Pseudomonas aeruginosa cultures and in the breath of cystic fibrosis (CF) patients with chronic (P. aeruginosa) infection. We investigated if exhaled breath HCN is an early marker of P. aeru... Read More about Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis.

Immediate delivery compared with expectant management after preterm pre-labour rupture of the membranes close to term (PPROMT trial): a randomised controlled trial (2015)
Journal Article
Morris, J. M., Roberts, C. L., Bowen, J. R., Patterson, J. A., Bond, D. M., Algert, C. S., Thornton, J., & Crowther, C. A. (2016). Immediate delivery compared with expectant management after preterm pre-labour rupture of the membranes close to term (PPROMT trial): a randomised controlled trial. Lancet, 387(10017), https://doi.org/10.1016/S0140-6736%2815%2900724-2

Background

Preterm pre-labour ruptured membranes close to term is associated with increased risk of neonatal infection, but immediate delivery is associated with risks of prematurity. The balance of risks is unclear. We aimed to establish whether... Read More about Immediate delivery compared with expectant management after preterm pre-labour rupture of the membranes close to term (PPROMT trial): a randomised controlled trial.

Maternal outcomes at 3 months after planned caesarean section versus planned vaginal birth for twin pregnancies in the Twin Birth Study: a randomised controlled trial (2015)
Journal Article
Hutton, E., Hannah, M., Joseph, K., Ohlsson, A., Asztalos, E., Willan, A., …Thornton, J. (2015). Maternal outcomes at 3 months after planned caesarean section versus planned vaginal birth for twin pregnancies in the Twin Birth Study: a randomised controlled trial. BJOG: An International Journal of Obstetrics and Gynaecology, 122(12), https://doi.org/10.1111/1471-0528.13597

OBJECTIVE:
To compare outcomes at 3 months post partum for women randomised to give birth by planned caesarean section (CS) or by planned vaginal birth (VB) in the Twin Birth Study (TBS).
DESIGN:
We invited women in the TBS to complete a 3-month f... Read More about Maternal outcomes at 3 months after planned caesarean section versus planned vaginal birth for twin pregnancies in the Twin Birth Study: a randomised controlled trial.

Maternal Body Weight and Gestational Diabetes Differentially Influence Placental and Pregnancy Outcomes (2015)
Journal Article
Martino, J., Sebert, S., Segura, M. T., García-Valdés, L., Florido, J., Padilla, M. C., …Campoy, C. (2016). Maternal Body Weight and Gestational Diabetes Differentially Influence Placental and Pregnancy Outcomes. Journal of Clinical Endocrinology and Metabolism, 101(1), 59-68. https://doi.org/10.1210/jc.2015-2590

Context:

Maternal obesity and gestational diabetes mellitus (GDM) can both contribute to adverse neonatal outcomes. The extent to which this may be mediated by differences in placental metabolism and nutrient transport remains to be determined.... Read More about Maternal Body Weight and Gestational Diabetes Differentially Influence Placental and Pregnancy Outcomes.