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The sterile alpha-motif (SAM) domain of p63 binds in vitro monoasialoganglioside (GM1) micelles (2011)
Journal Article
Rufini, S., Lena, A. M., Cadot, B., Mele, S., Amelio, I., Terrinoni, A., …Candi, E. (2011). The sterile alpha-motif (SAM) domain of p63 binds in vitro monoasialoganglioside (GM1) micelles. Biochemical Pharmacology, 82(10), 1262-1268. https://doi.org/10.1016/j.bcp.2011.07.087

The transcription factor p63 plays pivotal roles in epidermal barrier formation and in embryonic development. The protein structures of TAp63 and ΔNp63α isoforms include a C-terminal steril alpha-motif (SAM) involved in protein–protein interaction. I... Read More about The sterile alpha-motif (SAM) domain of p63 binds in vitro monoasialoganglioside (GM1) micelles.

Uniform cell colonization of porous 3-D scaffolds achieved using radial control of surface chemistry (2011)
Journal Article
Intranuovo, F., Howard, D., White, L. J., Johal, R. K., Ghaemmaghami, A. M., Favia, P., …Alexander, M. R. (2011). Uniform cell colonization of porous 3-D scaffolds achieved using radial control of surface chemistry. Acta Biomaterialia, 7(9), 3336-3344. https://doi.org/10.1016/j.actbio.2011.05.020

Uniform cellular distribution is a prerequisite to forming tissue within porous scaffolds, but the seeding process often results in preferential adhesion of cells at the periphery. We develop a vapour phase coating strategy which is readily applicabl... Read More about Uniform cell colonization of porous 3-D scaffolds achieved using radial control of surface chemistry.

Hepatitis C patient-derived glycoproteins exhibit marked differences in susceptibility to serum neutralizing antibodies: Genetic subtype defines antigenic but not neutralization serotype (2011)
Journal Article
Tarr, A. W., Urbanowicz, R. A., Hamed, M. R., Albecka, A., McClure, C. P., Brown, R. J., …Ball, J. K. (2011). Hepatitis C patient-derived glycoproteins exhibit marked differences in susceptibility to serum neutralizing antibodies: Genetic subtype defines antigenic but not neutralization serotype. Journal of Virology, 85(9), 4246-4257. https://doi.org/10.1128/JVI.01332-10

Neutralizing antibodies have a role in controlling hepatitis C virus (HCV) infection. A successful vaccine will need to elicit potently neutralizing antibodies that are capable of preventing the infection of genetically diverse viral isolates. Howeve... Read More about Hepatitis C patient-derived glycoproteins exhibit marked differences in susceptibility to serum neutralizing antibodies: Genetic subtype defines antigenic but not neutralization serotype.

Crohn disease: A current perspective on genetics, autophagy and immunity (2011)
Journal Article
Stappenbeck, T. S., Rioux, J. D., Mizoguchi, A., Saitoh, T., Huett, A., Darfeuille-Michaud, A., …Xavier, R. J. (2011). Crohn disease: A current perspective on genetics, autophagy and immunity. Autophagy, 7(4), 355-374. https://doi.org/10.4161/auto.7.4.13074

Crohn disease (CD) is a chronic and debilitating inflammatory condition of the gastrointestinal tract.1 Prevalence in western populations is 100-150/100,000 and somewhat higher in Ashkenazi Jews. Peak incidence is in early adult life, although any ag... Read More about Crohn disease: A current perspective on genetics, autophagy and immunity.

PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1 (2011)
Journal Article
Foxler, D. E., James, V., Shelton, S. J., de A. Vallim, T. Q., Shaw, P. E., & Sharp, T. V. (2011). PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1. FEBS Letters, 585(7), 1089-1096. https://doi.org/10.1016/j.febslet.2011.03.013

LIMD1 is a tumour suppressor gene (TSG) down regulated in ?80% of lung cancers with loss also demonstrated in breast and head and neck squamous cell carcinomas. LIMD1 is also a candidate TSG in childhood acute lymphoblastic leukaemia. Mechanistically... Read More about PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1.

Biomimetic bone scaffolds based on chitosan and calcium phosphates (2011)
Journal Article
Tanase, C., Popa, M., & Verestiuc, L. (2011). Biomimetic bone scaffolds based on chitosan and calcium phosphates. Materials Letters, 65(11), 1681-1683. https://doi.org/10.1016/j.matlet.2011.02.077

This paper reports a novel biomimetic technique for obtaining chitosan–calcium phosphate composite scaffolds (Cs–CP) by calcium phosphate precipitation from its precursors,CaCl2 and NaH2PO4 in the presence of ammonia and Cs, followed by product freez... Read More about Biomimetic bone scaffolds based on chitosan and calcium phosphates.

Identification of new functional regions in hepatitis C virus envelope glycoprotein E2 (2011)
Journal Article
Albecka, A., Montserret, R., Krey, T., Tarr, A. W., Diesis, E., Ball, J. K., …Dubuisson, J. (2011). Identification of new functional regions in hepatitis C virus envelope glycoprotein E2. Journal of Virology, 85(4), 1777-1792. https://doi.org/10.1128/JVI.02170-10

Little is known about the structure of the envelope glycoproteins of hepatitis C virus (HCV). To identify new regions essential for the function of these glycoproteins, we generated HCV pseudoparticles (HCVpp) containing HCV envelope glycoproteins, E... Read More about Identification of new functional regions in hepatitis C virus envelope glycoprotein E2.

Structure-activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A) (2010)
Journal Article
van Veldhoven, J. P. D., Blad, C. C., Artsen, C. M., Klopman, C., Wolfram, D. R., Abdelkadir, M. J., …IJzerman, A. P. (2011). Structure-activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A). Bioorganic and Medicinal Chemistry, 21(9), 2736-2739. https://doi.org/10.1016/j.bmcl.2010.11.091

Nicotinic acid (niacin) has been used for decades as an antidyslipidemic drug in man. Its main target is the hydroxy-carboxylic acid receptor HCA2 (GPR109A), a G protein-coupled receptor. Other acids and esters such as methyl fumarate also interact w... Read More about Structure-activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A).