Outputs (174)

Cell response to plasma electrolytic oxidation surface-modified low-modulus ?-type titanium alloys (2018)
Journal Article
Tanase, C., Golozar, M., Best, S., & Brooks, R. (2021). Cell response to plasma electrolytic oxidation surface-modified low-modulus ?-type titanium alloys. Colloids and Surfaces B: Biointerfaces, 176, 176-184. https://doi.org/10.1016/j.colsurfb.2018.12.064

Plasma electrolytic oxidation (PEO) has been demonstrated to be an effective surface treatment for enhancing the osteoconduction and osseointegration of commercially pure ?-Ti (CP ?-Ti) dental implant materials for clinical application. To explore th... Read More about Cell response to plasma electrolytic oxidation surface-modified low-modulus ?-type titanium alloys.

Cell death pathologies: targeting death pathways and the immune system for cancer therapy (2018)
Journal Article
Pentimalli, F., Grelli, S., Di Daniele, N., Melino, G., & Amelio, I. (2019). Cell death pathologies: targeting death pathways and the immune system for cancer therapy. Genes and Immunity, 20(7), 539-554. https://doi.org/10.1038/s41435-018-0052-x

Alterations in the molecular mechanisms of cell death are a common feature of cancer. These alterations enable malignant cells to survive intrinsic death signalling leading to accumulation of genetic aberrations and helping them to cope with adverse... Read More about Cell death pathologies: targeting death pathways and the immune system for cancer therapy.

Neurovascular structures in human vastus lateralis muscle and the ideal biopsy site (2018)
Journal Article
Chen, X., Abbey, S., Bharmal, A., Harris, S., Hudson, E., Krinner, L., …Billeter, R. (2019). Neurovascular structures in human vastus lateralis muscle and the ideal biopsy site. Scandinavian Journal of Medicine and Science in Sports, 29(4), 504-514. https://doi.org/10.1111/sms.13369

A density model of neurovascular structures was generated from 28 human vastus lateralis muscles isolated from embalmed cadavers. The intramuscular portion of arteries, veins and nerves was dissected, traced on transparencies and digitised before adj... Read More about Neurovascular structures in human vastus lateralis muscle and the ideal biopsy site.

SOX9 regulated matrix proteins are increased in patients serum and correlate with severity of liver fibrosis (2018)
Journal Article
Athwal, V. S., Pritchett, J., Martin, K., Llewellyn, J., Scott, J., Harvey, E., …Hanley, K. P. (2018). SOX9 regulated matrix proteins are increased in patients serum and correlate with severity of liver fibrosis. Scientific Reports, 8(1), Article 17905. https://doi.org/10.1038/s41598-018-36037-4

Extracellular matrix (ECM) deposition and resultant scar play a major role in the pathogenesis and progression of liver fibrosis. Identifying core regulators of ECM deposition may lead to urgently needed diagnostic and therapetic strategies for the d... Read More about SOX9 regulated matrix proteins are increased in patients serum and correlate with severity of liver fibrosis.

Profiling of 54 plasma glycoproteins by label-free targeted LC-MS/MS (2018)
Journal Article
Dahabiyeh, L. A., Tooth, D., & Barrett, D. A. (2019). Profiling of 54 plasma glycoproteins by label-free targeted LC-MS/MS. Analytical Biochemistry, 567, 72-81. https://doi.org/10.1016/j.ab.2018.12.011

Glycoproteins play a central role in diverse biological processes and are linked with many serious human diseases. In this paper we present a simple, reproducible and cost-effective analytical workflow that enables the reliable quantification of clin... Read More about Profiling of 54 plasma glycoproteins by label-free targeted LC-MS/MS.

Plasmodium centrin PbCEN-4 localizes to the putative MTOC and is dispensable for malaria parasite proliferation (2018)
Journal Article
Roques, M., Stanway, R. R., Rea, E. I., Markus, R., Brady, D., Holder, A. A., …Tewari, R. (2018). Plasmodium centrin PbCEN-4 localizes to the putative MTOC and is dispensable for malaria parasite proliferation. Biology Open, 8(1), Article bio.036822. https://doi.org/10.1242/bio.036822

Centrins are calmodulin-like phosphoproteins present in the centrosome and play an active role in the duplication, separation and organization of centrosomal structures such as the microtubule-organizing centre (MTOC) during mitosis. They are also ma... Read More about Plasmodium centrin PbCEN-4 localizes to the putative MTOC and is dispensable for malaria parasite proliferation.

Cooperation between protein kinase A (PKA) and high osmolarity glycerol reponse (HOG) pathways is affecting cell wall carbohydrate mobilization in Aspergillus fumigatus (2018)
Journal Article
de Assis, L. J., Manfiolli, A., Mattos, E., Malavazi, I., Jacobsen, I. D., Brock, M., …Goldman, G. H. (2018). Cooperation between protein kinase A (PKA) and high osmolarity glycerol reponse (HOG) pathways is affecting cell wall carbohydrate mobilization in Aspergillus fumigatus. mBio, 9(6), Article e01952-18

Aspergillus fumigatus mitogen-activated protein kinases (MAPKs) are involved in maintaining the normal morphology of the cell wall and providing resistance against cell wall-damaging agents. Upon cell wall stress, cell wall-related sugars need to be... Read More about Cooperation between protein kinase A (PKA) and high osmolarity glycerol reponse (HOG) pathways is affecting cell wall carbohydrate mobilization in Aspergillus fumigatus.

The use of decellularised animal tissue to study disseminating cancer cells (2018)
Journal Article
Grey, J. F. E., Campbell-Ritchie, A., Everitt, N. M., Fezovich, A. J., & Wheatley, S. P. (2019). The use of decellularised animal tissue to study disseminating cancer cells. Journal of Cell Science, 132(4), Article jcs219907. https://doi.org/10.1242/jcs.219907

Since the establishment of cell culture, common practice has been to grow adherent cells in 2D monolayers. Although cells behave completely differently when grown under these artificial conditions, the ease of 2D culturing has meant that this practic... Read More about The use of decellularised animal tissue to study disseminating cancer cells.

TAp73 regulates ATP7A: possible implications for ageing-related diseases (2018)
Journal Article
Lopriore, P., Capitanio, N., Panatta, E., Di Daniele, N., Gambacurta, A., Melino, G., & Amelio, I. (2018). TAp73 regulates ATP7A: possible implications for ageing-related diseases. Aging, 10(12), 3745-3760. https://doi.org/10.18632/aging.101669

The p53 family member p73 controls a wide range of cellular function. Deletion of p73 in mice results in increased tumorigenesis, infertility, neurological defects and altered immune system. Despite the extensive effort directed to define the molecul... Read More about TAp73 regulates ATP7A: possible implications for ageing-related diseases.

Cross-chemistry leads to product diversity from atromentin synthetases in Aspergilli from section Nigri (2018)
Journal Article
Geib, E., Baldeweg, F., Doerfer, M., Nett, M., & Brock, M. (2019). Cross-chemistry leads to product diversity from atromentin synthetases in Aspergilli from section Nigri. Cell Chemical Biology, 26(2), 223-234.e6. https://doi.org/10.1016/j.chembiol.2018.10.021

Nonribosomal peptide synthetase (NRPS)-like enzymes catalyse the non-oxidative homodimerisation of aromatic ?-keto acids, but the exact reaction mechanism is unknown. The furanone-forming thioesterase domain of the Aspergillus terreus aspulvinone E s... Read More about Cross-chemistry leads to product diversity from atromentin synthetases in Aspergilli from section Nigri.