Outputs (211)

Trypanosome outer kinetochore proteins suggest conservation of chromosome segregation machinery across eukaryotes (2016)
Journal Article
D’Archivio, S., & Wickstead, B. (2017). Trypanosome outer kinetochore proteins suggest conservation of chromosome segregation machinery across eukaryotes. Journal of Cell Biology, 216(2), 379-391. https://doi.org/10.1083/jcb.201608043

Kinetochores are multiprotein complexes that couple eukaryotic chromosomes to the mitotic spindle to ensure proper segregation. The model for kinetochore assembly is conserved between humans and yeast, and homologues of several components are widely... Read More about Trypanosome outer kinetochore proteins suggest conservation of chromosome segregation machinery across eukaryotes.

Nature knows best: employing whole microbial strategies to tackle antibiotic resistant pathogens (2016)
Journal Article
Tyson, J., & Elizabeth Sockett, R. (2017). Nature knows best: employing whole microbial strategies to tackle antibiotic resistant pathogens. Environmental Microbiology Reports, 9(1), 47-49. https://doi.org/10.1111/1758-2229.12518

Intra-arterial nitroglycerin as directed acute treatment in experimental ischemic stroke (2016)
Journal Article
Maniskas, M. E., Roberts, J. M., Trueman, R. C., Learoyd, A. E., Gorman, A., Fraser, J. F., & Bix, G. J. (in press). Intra-arterial nitroglycerin as directed acute treatment in experimental ischemic stroke. Journal of NeuroInterventional Surgery, 10(1), https://doi.org/10.1136/neurintsurg-2016-012793

Background: Nitroglycerin (also known as glyceryl trinitrate (GTN)), a vasodilator best known for treatment of ischemic heart disease, has also been investigated for its potential therapeutic benefit in ischemic stroke. The completed Efficacy of Nitr... Read More about Intra-arterial nitroglycerin as directed acute treatment in experimental ischemic stroke.

Antibiotic Spider Silk: Site-Specific Functionalization of Recombinant Spider Silk Using “Click” Chemistry (2016)
Journal Article
Harvey, D., Bardelang, P., Goodacre, S. L., Cockayne, A., & Thomas, N. R. (2017). Antibiotic Spider Silk: Site-Specific Functionalization of Recombinant Spider Silk Using “Click” Chemistry. Advanced Materials, 29(10), 1-5. https://doi.org/10.1002/adma.201604245

The use of functionalised recombinant spider silk as a sustainable advanced biomaterial is currently an area of intense interest owing to spider silk’s intrinsic strength, toughness, biocompatibility and biodegradability. This paper demonstrates, for... Read More about Antibiotic Spider Silk: Site-Specific Functionalization of Recombinant Spider Silk Using “Click” Chemistry.

Inorganic Nitrate Mimics Exercise-Stimulated Muscular Fiber-Type Switching and Myokine and ?-Aminobutyric Acid Release (2016)
Journal Article
Roberts, L. D., Ashmore, T., McNally, B. D., Murfitt, S. A., Fernandez, B. O., Feelisch, M., …Griffin, J. L. (2017). Inorganic Nitrate Mimics Exercise-Stimulated Muscular Fiber-Type Switching and Myokine and γ-Aminobutyric Acid Release. Diabetes, 66(3), 674-688. https://doi.org/10.2337/db16-0843

© 2017 by the American Diabetes Association. Exercise is an effective intervention for the prevention and treatment of type 2 diabetes. Skeletal muscle combines multiple signals that contribute to the beneficial effects of exercise on cardiometabolic... Read More about Inorganic Nitrate Mimics Exercise-Stimulated Muscular Fiber-Type Switching and Myokine and ?-Aminobutyric Acid Release.

Exploring the shell-based taxonomy of the Sri Lankan land snail Corilla H. and A. Adams, 1855 (Pulmonata: Corillidae) using mitochondrial DNA (2016)
Journal Article
Raheem, D., Breugelmans, K., Wade, C. M., Naggs, F., & Backeljau, T. (2017). Exploring the shell-based taxonomy of the Sri Lankan land snail Corilla H. and A. Adams, 1855 (Pulmonata: Corillidae) using mitochondrial DNA. Molecular Phylogenetics and Evolution, 107, https://doi.org/10.1016/j.ympev.2016.12.020

The land-snail genus Corilla is endemic to Sri Lanka and India’s Western Ghats. The ten extant Sri Lankan species belong to two distinct shell forms that are associated respectively with lowland and montane rainforest. We here present the first molec... Read More about Exploring the shell-based taxonomy of the Sri Lankan land snail Corilla H. and A. Adams, 1855 (Pulmonata: Corillidae) using mitochondrial DNA.

Widespread inter- and intra-domain horizontal gene transfer of d-amino acid metabolism enzymes in eukaryotes (2016)
Journal Article
Naranjo-Ortíz, M. A., Brock, M., Brunke, S., Hube, B., Marcet-Houben, M., & Gabaldón, T. (2016). Widespread inter- and intra-domain horizontal gene transfer of d-amino acid metabolism enzymes in eukaryotes. Frontiers in Microbiology, 7, https://doi.org/10.3389/fmicb.2016.02001

Analysis of the growing number of available fully-sequenced genomes has shown that Horizontal Gene Transfer (HGT) in eukaryotes is more common than previously thought. It has been proposed that genes with certain functions may be more prone to HGT th... Read More about Widespread inter- and intra-domain horizontal gene transfer of d-amino acid metabolism enzymes in eukaryotes.

Which traits do observers use to distinguish Batesian mimics from their models? (2016)
Journal Article
Taylor, C. H., Warrin, J., Gilbert, F., & Reader, T. (in press). Which traits do observers use to distinguish Batesian mimics from their models?. Behavioral Ecology, 28(2), https://doi.org/10.1093/beheco/arw166

Batesian mimicry, in which a harmless mimic resembles a more aversive model, can encompass a wide range of morphological traits, but the resemblance is never perfect. Previous studies have used abstract “prey” designs to show that differences in cert... Read More about Which traits do observers use to distinguish Batesian mimics from their models?.

5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus (2016)
Journal Article
Zapotoczna, M., Murray, E. J., Hogan, S., O'Gara, J. P., Chhabra, S. R., Chan, W. C., …Williams, P. (2017). 5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus. Journal of Antimicrobial Chemotherapy, 72(3), 744-753. https://doi.org/10.1093/jac/dkw482

Objectives: Biofilm infections of intravascular catheters caused by Staphylococcus aureus may be treated with catheter lock solutions (CLSs). Here we investigated the antibacterial activity, cytotoxicity and CLS potential of 5-hydroxyethyl-3-tetradec... Read More about 5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus.

M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss (2016)
Journal Article
Bradley, S. J., Bourgognon, J., Sanger, H. E., Verity, N., Mogg, A. J., White, D. J., …Tobin, A. B. (2017). M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss. Journal of Clinical Investigation, 127(2), 487-499. https://doi.org/10.1172/jci87526

The current frontline symptomatic treatment for Alzheimer’s disease (AD) is whole-body upregulation of cholinergic transmission via inhibition of acetylcholinesterase. This approach leads to profound dose-related adverse effects. An alternative strat... Read More about M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss.