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Structure-activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A) (2010)
Journal Article
van Veldhoven, J. P. D., Blad, C. C., Artsen, C. M., Klopman, C., Wolfram, D. R., Abdelkadir, M. J., …IJzerman, A. P. (2011). Structure-activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A). Bioorganic and Medicinal Chemistry, 21(9), 2736-2739. https://doi.org/10.1016/j.bmcl.2010.11.091

Nicotinic acid (niacin) has been used for decades as an antidyslipidemic drug in man. Its main target is the hydroxy-carboxylic acid receptor HCA2 (GPR109A), a G protein-coupled receptor. Other acids and esters such as methyl fumarate also interact w... Read More about Structure-activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A).

Knockdown of microRNA-21 Inhibits Proliferation and Increases Cell Death by Targeting Programmed Cell Death 4 (PDCD4) in Pancreatic Ductal Adenocarcinoma (2010)
Journal Article
Bhatti, I., Lee, A., James, V., Hall, R. I., Lund, J. N., Tufarelli, C., …Larvin, M. (2011). Knockdown of microRNA-21 Inhibits Proliferation and Increases Cell Death by Targeting Programmed Cell Death 4 (PDCD4) in Pancreatic Ductal Adenocarcinoma. Journal of Gastrointestinal Surgery, 15(1), 199-208. https://doi.org/10.1007/s11605-010-1381-x

The role of glyceraldehyde 3-phosphate dehydrogenase (GapA-1) in Neisseria meningitidis adherence to human cells (2010)
Journal Article
Tunio, S. A., Oldfield, N. J., Ala'Aldeen, D. A. A., Wooldridge, K. G., & Turner, D. P. J. (2010). The role of glyceraldehyde 3-phosphate dehydrogenase (GapA-1) in Neisseria meningitidis adherence to human cells. BMC Microbiology, 10, Article 280. https://doi.org/10.1186/1471-2180-10-280

Background Glyceraldehyde 3-phosphate dehydrogenases (GAPDHs) are cytoplasmic glycolytic enzymes, which although lacking identifiable secretion signals, have also been found localized to the surface of several bacteria (and some eukaryotic organisms... Read More about The role of glyceraldehyde 3-phosphate dehydrogenase (GapA-1) in Neisseria meningitidis adherence to human cells.

Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins (2010)
Journal Article
Coelho, V., Krysov, S., Ghaemmaghami, A. M., Emara, M., Potter, K. N., Johnson, P., …Stevenson, F. K. (2010). Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins. Proceedings of the National Academy of Sciences, 107(43), 18587-18592. https://doi.org/10.1073/pnas.1009388107

Surface Ig (sIg) of follicular lymphoma (FL) is vital for tumor cell survival. We found previously that the Ig in FL is unusual, because the variable region genes carry sequence motifs for N-glycan addition. These are introduced by somatic mutation a... Read More about Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins.

Label-free molecular imaging of immunological synapses between dendritic and T cells by Raman micro-spectroscopy (2010)
Journal Article
Zoladek, A. B., Johal, R. K., Garcia-Nieto, S., Pascut, F., Shakesheff, K. M., Ghaemmaghami, A. M., & Notingher, I. (2010). Label-free molecular imaging of immunological synapses between dendritic and T cells by Raman micro-spectroscopy. Analyst, 135(12), 3205-3212. https://doi.org/10.1039/c0an00508h

Confocal Raman micro-spectroscopy (CRMS) was used to measure spectral images of immunological synapse formation between dendritic and T cells without using molecular labels or other invasive procedures. The purpose-built inverted CRMS instrument inte... Read More about Label-free molecular imaging of immunological synapses between dendritic and T cells by Raman micro-spectroscopy.

Comparative transcriptional profiling of the limbal epithelial crypt demonstrates its putative stem cell niche characteristics (2010)
Journal Article
Kulkarni, B. B., Tighe, P. J., Mohammed, I., Yeung, A. M., Powe, D. G., Hopkinson, A., …Dua, H. S. (2010). Comparative transcriptional profiling of the limbal epithelial crypt demonstrates its putative stem cell niche characteristics. BMC Genomics, 11(1), Article 526. https://doi.org/10.1186/1471-2164-11-526

Background: The Limbal epithelial crypt (LEC) is a solid cord of cells, approximately 120 microns long. It arises from the undersurface of interpalisade rete ridges of the limbal palisades of Vogt and extends deeper into the limbal stroma parallel or... Read More about Comparative transcriptional profiling of the limbal epithelial crypt demonstrates its putative stem cell niche characteristics.

Human antibody responses to the meningococcal factor H binding protein (LP2086) during invasive disease, colonization and carriage (2010)
Journal Article
Ala'Aldeen, D. A., Flint, M., Oldfield, N. J., Omer, S. A., McNeil, L. K., Jiang, Q., …Anderson, A. S. (2010). Human antibody responses to the meningococcal factor H binding protein (LP2086) during invasive disease, colonization and carriage. Vaccine, 28(48), 7667-7675. https://doi.org/10.1016/j.vaccine.2010.09.038

Recombinant forms of Neisseria meningitidis factor H binding protein (fHBP) are undergoing clinical trials in candidate vaccines against serogroup B meningococcal disease. Little is known, however, about the host response to fHBP during natural carri... Read More about Human antibody responses to the meningococcal factor H binding protein (LP2086) during invasive disease, colonization and carriage.

Hormone transport (2010)
Book Chapter
Kerr, I. D., Carrier, D. J., & Twycross, J. (2010). Hormone transport. In The Plant Plasma Membrane, (379-397). Springer. https://doi.org/10.1007/978-3-642-13431-9_17

Hormone transport in plants is a fundamental process governing all aspects of plant development. Identification and functional analysis of plasma membrane proteins, which regulate the import and export of plant hormones, is a requirement if we are to... Read More about Hormone transport.

Pseudomonas aeruginosaHomoserine Lactone Activates Store-operated cAMP and Cystic Fibrosis Transmembrane Regulator-dependent Cl?Secretion by Human Airway Epithelia (2010)
Journal Article
Schwarzer, C., Wong, S., Shi, J., Matthes, E., Illek, B., Ianowski, J. P., …Machen, T. E. (2010). Pseudomonas aeruginosaHomoserine Lactone Activates Store-operated cAMP and Cystic Fibrosis Transmembrane Regulator-dependent Cl−Secretion by Human Airway Epithelia. Journal of Biological Chemistry, 285(45), 34850-34863. https://doi.org/10.1074/jbc.m110.167668

The ubiquitous bacterium Pseudomonas aeruginosa frequently causes hospital-acquired infections. P. aeruginosa also infects the lungs of cystic fibrosis (CF) patients and secretes N-(3-oxo-dodecanoyl)-S-homoserine lactone (3O-C12) to regulate bacteria... Read More about Pseudomonas aeruginosaHomoserine Lactone Activates Store-operated cAMP and Cystic Fibrosis Transmembrane Regulator-dependent Cl?Secretion by Human Airway Epithelia.