Outputs (28)

Functional Characterization of AasP, a Maturation Protease Autotransporter Protein of Actinobacillus pleuropneumoniae (2008)
Journal Article
Ali, T., Oldfield, N. J., Wooldridge, K. G., Turner, D. P., & Ala'Aldeen, D. A. A. (2008). Functional Characterization of AasP, a Maturation Protease Autotransporter Protein of Actinobacillus pleuropneumoniae. Infection and Immunity, 76(12), 5608-5614. https://doi.org/10.1128/IAI.00085-08

Actinobacillus pleuropneumoniae is the etiological agent of porcine pleuropneumonia, a highly contagious respiratory infection in pigs. AasP, a putative subtilisin-like serine protease autotransporter, has recently been identified in A. pleuropneumon... Read More about Functional Characterization of AasP, a Maturation Protease Autotransporter Protein of Actinobacillus pleuropneumoniae.

Do humans prefer altruistic mates? Testing a link between sexual selection and altruism towards non-relatives (2008)
Journal Article
Phillips, T., Barnard, C., Ferguson, E., & Reader, T. (2008). Do humans prefer altruistic mates? Testing a link between sexual selection and altruism towards non-relatives. British Journal of Psychology, 99(4), 555-572. https://doi.org/10.1348/000712608X298467

Humans are often seen as unusual in displaying altruistic behaviour towards nonrelatives. Here we outline and test a hypothesis that human altruistic traits evolved as a result of sexual selection. We develop a psychometric scale to measure mate pref... Read More about Do humans prefer altruistic mates? Testing a link between sexual selection and altruism towards non-relatives.

The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist (2008)
Journal Article
Jaakola, V., Griffith, M. T., Hanson, M. A., Cherezov, V., Chien, E. Y. T., Lane, J. R., …Stevens, R. C. (2008). The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. Science, 322(5905), 1211-1217. https://doi.org/10.1126/science.1164772

The adenosine class of heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) mediates the important role of extracellular adenosine in many physiological processes and is antagonized by caffeine. We have determined t... Read More about The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist.

An inside job: Bdellovibrio bacteriovorus (2008)
Journal Article
Sockett, L., Hobley, L., Fenton, A., Woods, R., Lambert, C., Chang, C. Y., …King, S. (2008). An inside job: Bdellovibrio bacteriovorus. Microbiology Today, 35(4), 184-187

The molecular basis of allergenicity (2008)
Journal Article
Shakib, F., Ghaemmaghami, A. M., & Sewell, H. F. (2008). The molecular basis of allergenicity. Trends in Immunology, 29(12), 633-642. https://doi.org/10.1016/j.it.2008.08.007

Allergens are mostly innocuous antigens that elicit powerful T helper cell type 2 (Th2) responses leading to hyper-immunoglobulin E (IgE) production and allergy. Research carried out over several years has highlighted the possible role of the inheren... Read More about The molecular basis of allergenicity.

Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant (2008)
Journal Article
Kuballa, P., Huett, A., Rioux, J. D., Daly, M. J., & Xavier, R. J. (2008). Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant. PLoS ONE, 3(10), Article e3391. https://doi.org/10.1371/journal.pone.0003391

The genetic risk factors predisposing individuals to the development of inflammatory bowel disease are beginning to be deciphered by genome-wide association studies. Surprisingly, these new data point towards a critical role of autophagy in the patho... Read More about Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant.

Developing novel anthelmintics from plant cysteine proteinases (2008)
Journal Article
Behnke, J. M., Buttle, D. J., Stepek, G., Lowe, A., & Duce, I. (2008). Developing novel anthelmintics from plant cysteine proteinases. Parasites and Vectors, 1(29), https://doi.org/10.1186/1756-3305-1-29

Intestinal helminth infections of livestock and humans are predominantly controlled by treatment with three classes of synthetic drugs, but some livestock nematodes have now developed resistance to all three classes and there are signs that human hoo... Read More about Developing novel anthelmintics from plant cysteine proteinases.

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease (2008)
Journal Article
McCarroll, S. A., Huett, A., Kuballa, P., Chilewski, S. D., Landry, A., Goyette, P., …Xavier, R. J. (2008). Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nature Genetics, 40(9), 1107-1112. https://doi.org/10.1038/ng.215

Following recent success in genome-wide association studies, a critical focus of human genetics is to understand how genetic variation at implicated loci influences cellular and disease processes. Crohn's disease (CD) is associated with SNPs around I... Read More about Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.

Temporal and between-site variation in helminth communities of bank voles (Myodes glareolus) from N.E. Poland. 1. Regional fauna and component community levels (2008)
Journal Article
Behnke, J. M., Bajer, A., Harris, P. D., Newington, L., Pidgeon, E., Rowlands, G., …Barnard, C. (2008). Temporal and between-site variation in helminth communities of bank voles (Myodes glareolus) from N.E. Poland. 1. Regional fauna and component community levels. Parasitology, 135(8), https://doi.org/10.1017/S0031182008004393

Helminth infections were studied in bank voles (Myodes glareolus) from 3 woodland sites in N.E. Poland in the late summers of 1999 and 2002, to assess the temporal stability of derived statistics describing the regional helminth fauna and component c... Read More about Temporal and between-site variation in helminth communities of bank voles (Myodes glareolus) from N.E. Poland. 1. Regional fauna and component community levels.

Allergen-driven suppression of thiol production by human dendritic cells and the effect of thiols on T cell function (2008)
Journal Article
Hasan, A. A., Ghaemmaghami, A. M., Fairclough, L., Robins, A., Sewell, H. F., & Shakib, F. (2009). Allergen-driven suppression of thiol production by human dendritic cells and the effect of thiols on T cell function. Immunobiology, 214(1), 2-16. https://doi.org/10.1016/j.imbio.2008.04.006

Dendritic cells are a major source of extracellular thiols needed for T cell activation, a process in which CD40-mediated stimulation plays a pivotal role. The Dermatophagoides pteronyssinus group 1 mite allergen (Der p 1) has previously been shown t... Read More about Allergen-driven suppression of thiol production by human dendritic cells and the effect of thiols on T cell function.