Skip to main content

Research Repository

Advanced Search

Outputs (33)

An immunoglobulin E-reactive chimeric human immunoglobulin G1 anti-idiotype inhibits basophil degranulation through cross-linking of FcεRI with FcγRIIb (2007)
Journal Article
Wigginton, S. J., Furtado, P. B., Armour, K. L., Clark, M. R., Robins, A., Emara, M., …Shakib, F. (2008). An immunoglobulin E-reactive chimeric human immunoglobulin G1 anti-idiotype inhibits basophil degranulation through cross-linking of FcεRI with FcγRIIb. Clinical and Experimental Allergy, 38(2), 313-319. https://doi.org/10.1111/j.1365-2222.2007.02896.x

Background: IgE binds to mast cells and basophils via its high-affinity receptor, FcεRI, and cross-linking of FcεRI-bound IgE molecules by allergen leads to the release of allergic mediators characteristic of type I hypersensitivity reactions. Previo... Read More about An immunoglobulin E-reactive chimeric human immunoglobulin G1 anti-idiotype inhibits basophil degranulation through cross-linking of FcεRI with FcγRIIb.

Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge (2007)
Journal Article
Law, M., Maruyama, T., Lewis, J., Giang, E., Tarr, A. W., Stamataki, Z., …Burton, D. R. (2008). Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge. Nature Medicine, 14(1), 25-27. https://doi.org/10.1038/nm1698

A major problem in hepatitis C virus (HCV) immunotherapy or vaccine design is the extreme variability of the virus. We identified human monoclonal antibodies (mAbs) that neutralize genetically diverse HCV isolates and protect against heterologous HCV... Read More about Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge.

Elevated CD16 expression by monocytes from patients with tumor necrosis factor receptor-associated periodic syndrome (2007)
Journal Article
Todd, I., Radford, P. M., Ziegler-Heitbrock, L., Ghaemmaghami, A. M., Powell, R. J., & Tighe, P. J. (2007). Elevated CD16 expression by monocytes from patients with tumor necrosis factor receptor-associated periodic syndrome. Arthritis and Rheumatism, 56(12), 4182-4188. https://doi.org/10.1002/art.23133

Objective. Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is an inherited autosomal-dominant autoinflammatory condition caused by mutations in the ectodomain of the 55-kd tumor necrosis factor (TNF) receptor superfamily 1A. Proin... Read More about Elevated CD16 expression by monocytes from patients with tumor necrosis factor receptor-associated periodic syndrome.

Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels (2007)
Journal Article
Pardon, M. C., Sarmad, S., Rattray, I., Bates, T. E., Scullion, G. A., Marsden, C. A., …Kendall, D. A. (2007). Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels. Neurobiology of Aging, 30(7), 1099-1113. https://doi.org/10.1016/j.neurobiolaging.2007.10.002

Environmental factors (e.g. stress, exercise, enrichment) are thought to play a role in the development of Alzheimer's disease later in life. We investigated the influence of repeated novel cage exposure on the development of early Alzheimer's-like p... Read More about Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels.

In vitro anthelmintic effects of cysteine proteinases from plants against intestinal helminths of rodents (2007)
Journal Article
Stepek, G., Lowe, A. E., Buttle, D. J., Duce, I. R., & Behnke, J. M. (2007). In vitro anthelmintic effects of cysteine proteinases from plants against intestinal helminths of rodents. Journal of Helminthology, 81(4), https://doi.org/10.1017/S0022149X0786408X

Infections with gastrointestinal (GI) nematodes are amongst the most prevalent worldwide, especially in tropical climates. Control of these infections is primarily through treatment with anthelmintic drugs, but the rapid development of resistance to... Read More about In vitro anthelmintic effects of cysteine proteinases from plants against intestinal helminths of rodents.

Molecular phylogeny of the helicoid land snails (Pulmonata: Stylommatophora: Helicoidea), with special emphasis on the Camaenidae (2007)
Journal Article
Wade, C. M., Hudelot, C., Davison, A., Naggs, F., & Mordan, P. B. (2007). Molecular phylogeny of the helicoid land snails (Pulmonata: Stylommatophora: Helicoidea), with special emphasis on the Camaenidae. Journal of Molluscan Studies, 73(4), 411-415. https://doi.org/10.1093/mollus/eym030

The superfamily Helicoidea is a large and diverse group of land snails belonging to the Pulmonate suborder Stylommatophora. It has an almost worldwide distribution, absent from only sub-Saharan Africa, southern South America, New Zealand and some Pac... Read More about Molecular phylogeny of the helicoid land snails (Pulmonata: Stylommatophora: Helicoidea), with special emphasis on the Camaenidae.

Determination of the human antibody response to the epitope defined by the hepatitis C virus-neutralizing monoclonal antibody AP33 (2007)
Journal Article
Tarr, A. W., Owsianka, A. M., Jayaraj, D., Brown, R. J., Hickling, T. P., Irving, W. L., …Ball, J. K. (2007). Determination of the human antibody response to the epitope defined by the hepatitis C virus-neutralizing monoclonal antibody AP33. Journal of General Virology, 88(11), 2991-3001. https://doi.org/10.1099/vir.0.83065-0

Hepatitis C virus (HCV) is a major cause of liver disease worldwide and there is a pressing need for the development of a preventative vaccine as well as new treatments. It was recently demonstrated that the mouse monoclonal antibody (mAb) AP33 poten... Read More about Determination of the human antibody response to the epitope defined by the hepatitis C virus-neutralizing monoclonal antibody AP33.

The small subunit (SSU) ribosomal (r) RNA gene as a genetic marker for identifying infective 3rd juvenile stage Angiostrongylus cantonensis (2007)
Journal Article
Fontanilla, I. K., & Wade, C. M. (2008). The small subunit (SSU) ribosomal (r) RNA gene as a genetic marker for identifying infective 3rd juvenile stage Angiostrongylus cantonensis. Acta Tropica, 105(2), 181-186. https://doi.org/10.1016/j.actatropica.2007.10.007

We have developed a molecular method using PCR-direct sequencing to identify the infective 3rd juvenile stage of Angiostrongylus cantonensis, a nematode parasite of rodents that can accidentally infect humans and cause eosinophilic meningitis. We dem... Read More about The small subunit (SSU) ribosomal (r) RNA gene as a genetic marker for identifying infective 3rd juvenile stage Angiostrongylus cantonensis.

Human combinatorial libraries yield rare antibodies that broadly neutralize hepatitis C virus (2007)
Journal Article
Johansson, D. X., Voisset, C., Tarr, A. W., Aung, M., Ball, J. K., Dubuisson, J., & Persson, M. A. (2007). Human combinatorial libraries yield rare antibodies that broadly neutralize hepatitis C virus. Proceedings of the National Academy of Sciences, 104(41), 16269-16274. https://doi.org/10.1073/pnas.0705522104

One way to dissect the antibody response to an invading microorganism is to clone the antibody repertoire from immune donors and subsequently characterize the specific antibodies. Recently, methodological advances have allowed investigations of neutr... Read More about Human combinatorial libraries yield rare antibodies that broadly neutralize hepatitis C virus.