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Outputs (28)

Optimization of the pseudoparticle system for standardized assessments of neutralizing antibodies against hepatitis C virus (2022)
Journal Article
Chumbe, A., Urbanowicz, R. A., Sliepen, K., Koekkoek, S. M., Molenkamp, R., Tarr, A. W., …van Gils, M. J. (2022). Optimization of the pseudoparticle system for standardized assessments of neutralizing antibodies against hepatitis C virus. Journal of General Virology, 103(11), Article 001801. https://doi.org/10.1099/jgv.0.001801

A better understanding of the antibody response during natural infection and the effect on disease progression and reinfection is necessary for the development of a protective hepatitis C virus (HCV) vaccine. The HCV pseudoparticle (HCVpp) system ena... Read More about Optimization of the pseudoparticle system for standardized assessments of neutralizing antibodies against hepatitis C virus.

Two doses of the SARS-CoV-2 BNT162b2 vaccine enhance antibody responses to variants in individuals with prior SARS-CoV-2 infection (2021)
Journal Article
Urbanowicz, R. A., Tsoleridis, T., Jackson, H. J., Cusin, L., Duncan, J. D., Chappell, J. G., …Ollivere, B. J. (2021). Two doses of the SARS-CoV-2 BNT162b2 vaccine enhance antibody responses to variants in individuals with prior SARS-CoV-2 infection. Science Translational Medicine, 13(609), Article eabj0847. https://doi.org/10.1126/scitranslmed.abj0847

Understanding the impact of prior infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the response to vaccination is a priority for responding to the coronavirus disease 2019 (COVID-19) pandemic. In particular, it is necess... Read More about Two doses of the SARS-CoV-2 BNT162b2 vaccine enhance antibody responses to variants in individuals with prior SARS-CoV-2 infection.

The Relationship of the Mechanisms of the Pathogenesis of Multiple Sclerosis and the Expression of Endogenous Retroviruses (2020)
Journal Article
Lezhnyova, V. R., Martynova, E. V., Khaiboullin, T. I., Urbanowicz, R. A., Khaiboullina, S. F., & Rizvanov, A. A. (2020). The Relationship of the Mechanisms of the Pathogenesis of Multiple Sclerosis and the Expression of Endogenous Retroviruses. Biology, 9(12), 1-16. https://doi.org/10.3390/biology9120464

Two human endogenous retroviruses of the HERV‐W family can act as cofactors triggering multiple sclerosis (MS): MS‐associated retrovirus (MSRV) and ERVWE1. Endogenous retroviral elements are believed to have integrated in our ancestors’ DNA millions... Read More about The Relationship of the Mechanisms of the Pathogenesis of Multiple Sclerosis and the Expression of Endogenous Retroviruses.

Polymer microarrays rapidly identify competitive adsorbents of virus-like particles (2020)
Journal Article
Blok, A. J., Gurnani, P., Xenopoulos, A., Burroughs, L., Duncan, J., Urbanowicz, R. A., …Alexander, M. R. (2020). Polymer microarrays rapidly identify competitive adsorbents of virus-like particles. Biointerphases, 15(6), Article 061005. https://doi.org/10.1116/6.0000586

The emergence of SARS-CoV-2 highlights the global need for platform technologies to enable the rapid development of diagnostics, vaccines, treatments, and personal protective equipment (PPE). However, many current technologies require the detailed me... Read More about Polymer microarrays rapidly identify competitive adsorbents of virus-like particles.

Polymer microarrays rapidly identify competitive adsorbents of virus-like particles (VLPs) (2020)
Journal Article
Blok, A. J., Gurnani, P., Xenopoulos, A., Burroughs, L., Duncan, J., Urbanowicz, R. A., …Alexander, M. R. (2020). Polymer microarrays rapidly identify competitive adsorbents of virus-like particles (VLPs). Biointerphases, 15, Article 061005. https://doi.org/10.1116/6.0000586

The emergence of SARS-CoV-2 highlights the global need for platform technologies to enable rapid development of diagnostics, vaccines, treatments, and personal protective equipment (PPE). However, many current technologies require the detailed mechan... Read More about Polymer microarrays rapidly identify competitive adsorbents of virus-like particles (VLPs).

Orthohantaviruses, Emerging Zoonotic Pathogens (2020)
Journal Article
Kabwe, E., Davidyuk, Y., Shamsutdinov, A., Garanina, E., Martynova, E., Kitaeva, K., …Khaiboullina, S. (2020). Orthohantaviruses, Emerging Zoonotic Pathogens. Pathogens, 9(9), Article 775. https://doi.org/10.3390/pathogens9090775

Orthohantaviruses give rise to the emerging infections such as of hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS) in Eurasia and the Americas, respectively. In this review we will provide a comprehensive analysis... Read More about Orthohantaviruses, Emerging Zoonotic Pathogens.

Role of HVR1 sequence similarity in the cross-genotypic neutralization of HCV (2020)
Journal Article
Mosa, A. I., AbouHaidar, M. G., Urbanowicz, R. A., Tavis, J. E., Ball, J. K., & Feld, J. J. (2020). Role of HVR1 sequence similarity in the cross-genotypic neutralization of HCV. Virology Journal, 17, Article 140. https://doi.org/10.1186/s12985-020-01408-9

Despite available treatments, a prophylactic HCV vaccine is needed to achieve elimination targets. HCV vaccine development has faltered largely because the extreme diversity of the virus limits the protective breadth of vaccine elicited antibodies. I... Read More about Role of HVR1 sequence similarity in the cross-genotypic neutralization of HCV.

Structure-Based Design of Hepatitis C Virus E2 Glycoprotein Improves Serum Binding and Cross-Neutralization (2020)
Journal Article
Pierce, B. G., Keck, Z. Y., Wang, R., Lau, P., Garagusi, K., Elkholy, K., …Foung, S. K. (2020). Structure-Based Design of Hepatitis C Virus E2 Glycoprotein Improves Serum Binding and Cross-Neutralization. Journal of Virology, 94(22), https://doi.org/10.1128/JVI.00704-20

Copyright © 2020 American Society for Microbiology. An effective vaccine for hepatitis C virus (HCV) is a major unmet need, and it requires an antigen that elicits immune responses to key conserved epitopes. Based on structures of antibodies targetin... Read More about Structure-Based Design of Hepatitis C Virus E2 Glycoprotein Improves Serum Binding and Cross-Neutralization.

Adjuvant formulated virus-like particles expressing native-like forms of the Lassa virus envelope surface glycoprotein are immunogenic and induce antibodies with broadly neutralizing activity (2020)
Journal Article
Müller, H., Fehling, S. K., Dorna, J., Urbanowicz, R. A., Oestereich, L., Krebs, Y., …Strecker, T. (2020). Adjuvant formulated virus-like particles expressing native-like forms of the Lassa virus envelope surface glycoprotein are immunogenic and induce antibodies with broadly neutralizing activity. npj Vaccines, 5, Article 71. https://doi.org/10.1038/s41541-020-00219-x

Lassa mammarenavirus (LASV) is a rodent-borne arenavirus endemic to several West African countries. It is the causative agent of human Lassa fever, an acute viral hemorrhagic fever disease. To date, no therapeutics or vaccines against LASV have obtai... Read More about Adjuvant formulated virus-like particles expressing native-like forms of the Lassa virus envelope surface glycoprotein are immunogenic and induce antibodies with broadly neutralizing activity.

A next generation vaccine against human rabies based on a single dose of a chimpanzee adenovirus vector serotype C (2020)
Journal Article
Napolitano, F., Merone, R., Abbate, A., Ammendola, V., Horncastle, E., Lanzaro, F., …Vitelli, A. (2020). A next generation vaccine against human rabies based on a single dose of a chimpanzee adenovirus vector serotype C. PLoS Neglected Tropical Diseases, 14(7), Article e0008459. https://doi.org/10.1371/journal.pntd.0008459

Rabies, caused by RNA viruses in the Genus Lyssavirus, is the most fatal of all infectious diseases. This neglected zoonosis remains a major public health problem in developing countries, causing the death of an estimated 25,000-159,000 people each y... Read More about A next generation vaccine against human rabies based on a single dose of a chimpanzee adenovirus vector serotype C.