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Development of a heptaplex PCR assay for identification of Staphylococcus aureus and CoNS with simultaneous detection of virulence and antibiotic resistance genes (2015)
Journal Article
Okolie, C. E., Wooldridge, K. G., Turner, D. P., Cockayne, A., & James, R. (2015). Development of a heptaplex PCR assay for identification of Staphylococcus aureus and CoNS with simultaneous detection of virulence and antibiotic resistance genes. BMC Microbiology, 15(1), Article 157. https://doi.org/10.1186/s12866-015-0490-9

Background Staphylococcal toxicity and antibiotic resistance (STAAR) have been menacing public health. Although vancomycin-resistant Staphylococcus aureus (VRSA) is currently not as widespread as methicillin-resistant S. aureus (MRSA), genome evolut... Read More about Development of a heptaplex PCR assay for identification of Staphylococcus aureus and CoNS with simultaneous detection of virulence and antibiotic resistance genes.

Crystal structure of the antimicrobial peptidase lysostaphin from Staphylococcus simulans (2014)
Journal Article
Sabala, I., Jagielska, E., Bardelang, P. T., Czapinska, H., Dahms, S. O., Sharpe, J. A., …Bochtler, M. (2014). Crystal structure of the antimicrobial peptidase lysostaphin from Staphylococcus simulans. FEBS Journal, 281(18), 4112-4122. https://doi.org/10.1111/febs.12929

Staphylococcus simulansbiovarstaphylolyticuslysostaphin efficiently cleavesStaphylococcus aureuscell walls. The protein is in late clinical trials as atopical anti-staphylococcal agent, and can be used to prevent staphylococcalgrowth on artificial su... Read More about Crystal structure of the antimicrobial peptidase lysostaphin from Staphylococcus simulans.

Internally quenched peptides for the study of lysostaphin: An antimicrobial protease that kills Staphylococcus aureus (2006)
Journal Article
Warfield, R., Bardelang, P., Saunders, H., Chan, W. C., Penfold, C., James, R., & Thomas, N. R. (2006). Internally quenched peptides for the study of lysostaphin: An antimicrobial protease that kills Staphylococcus aureus. Organic and Biomolecular Chemistry, 4(19), 3626-3638. https://doi.org/10.1039/b607999g

Lysostaphin (EC. 3.4.24.75) is a protein secreted by Staphylococcus simulans biovar staphylolyticus and has been shown to be active against methicillin resistant S. aureus (MRSA). The design and synthesis of three internally quenched substrates for l... Read More about Internally quenched peptides for the study of lysostaphin: An antimicrobial protease that kills Staphylococcus aureus.