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Cortical oxygen extraction fraction using quantitative BOLD MRI and cerebral blood flow during vasodilation (2023)
Journal Article
Le, L. N. N., Wheeler, G. J., Holy, E. N., Donnay, C. A., Blockley, N. P., Yee, A. H., …Fan, A. P. (2023). Cortical oxygen extraction fraction using quantitative BOLD MRI and cerebral blood flow during vasodilation. Frontiers in Physiology, 14, Article 1231793. https://doi.org/10.3389/fphys.2023.1231793

Introduction: We aimed to demonstrate non-invasive measurements of regional oxygen extraction fraction (OEF) from quantitative BOLD MRI modeling at baseline and after pharmacological vasodilation. We hypothesized that OEF decreases in response to vas... Read More about Cortical oxygen extraction fraction using quantitative BOLD MRI and cerebral blood flow during vasodilation.

Modelling spatiotemporal dynamics of cerebral blood flow using multiple-timepoint arterial spin labelling MRI (2023)
Journal Article
Pinto, J., Blockley, N. P., Harkin, J. W., & Bulte, D. P. (2023). Modelling spatiotemporal dynamics of cerebral blood flow using multiple-timepoint arterial spin labelling MRI. Frontiers in Physiology, 14, Article 1142359. https://doi.org/10.3389/fphys.2023.1142359

Introduction: Cerebral blood flow (CBF) is an important physiological parameter that can be quantified non-invasively using arterial spin labelling (ASL) imaging. Although most ASL studies are based on single-timepoint strategies, multi-timepoint app... Read More about Modelling spatiotemporal dynamics of cerebral blood flow using multiple-timepoint arterial spin labelling MRI.

Quantitative chemical exchange saturation transfer imaging of nuclear overhauser effects in acute ischemic stroke (2022)
Journal Article
Msayib, Y., Harston, G. W., Ray, K. J., Larkin, J. R., Sutherland, B. A., Sheerin, F., …Chappell, M. A. (2022). Quantitative chemical exchange saturation transfer imaging of nuclear overhauser effects in acute ischemic stroke. Magnetic Resonance in Medicine, 88(1), 341-356. https://doi.org/10.1002/mrm.29187

Purpose: In chemical exchange saturation transfer imaging, saturation effects between (Formula presented.) 2 to (Formula presented.) 5 ppm (nuclear Overhauser effects, NOEs) have been shown to exhibit contrast in preclinical stroke models. Our previo... Read More about Quantitative chemical exchange saturation transfer imaging of nuclear overhauser effects in acute ischemic stroke.

Study Protocol: The Heart and Brain Study (2021)
Journal Article
Suri, S., Bulte, D., Chiesa, S. T., Ebmeier, K. P., Jezzard, P., Rieger, S. W., …Mackay, C. E. (2021). Study Protocol: The Heart and Brain Study. Frontiers in Physiology, 12, Article 643725. https://doi.org/10.3389/fphys.2021.643725

Background: It is well-established that what is good for the heart is good for the brain. Vascular factors such as hypertension, diabetes, and high cholesterol, and genetic factors such as the apolipoprotein E4 allele increase the risk of developing... Read More about Study Protocol: The Heart and Brain Study.

Simulations of the effect of diffusion on asymmetric spin echo based quantitative BOLD: An investigation of the origin of deoxygenated blood volume overestimation (2019)
Journal Article
Stone, A. J., Holland, N. C., Berman, A. J., & Blockley, N. P. (2019). Simulations of the effect of diffusion on asymmetric spin echo based quantitative BOLD: An investigation of the origin of deoxygenated blood volume overestimation. NeuroImage, 201, Article 116035. https://doi.org/10.1016/j.neuroimage.2019.116035

Quantitative BOLD (qBOLD) is a technique for mapping oxygen extraction fraction (OEF) and deoxygenated blood volume (DBV) in the human brain. Recent measurements using an asymmetric spin echo (ASE) based qBOLD approach produced estimates of DBV which... Read More about Simulations of the effect of diffusion on asymmetric spin echo based quantitative BOLD: An investigation of the origin of deoxygenated blood volume overestimation.

Prospects for investigating brain oxygenation in acute stroke: experience with a non-contrast quantitative BOLD based approach (2019)
Journal Article
Stone, A. J., Harston, G. W. J., Carone, D., Okell, T. W., Kennedy, J., & Blockley, N. P. (2019). Prospects for investigating brain oxygenation in acute stroke: experience with a non-contrast quantitative BOLD based approach. Human Brain Mapping, 40(10), 2853-2866. https://doi.org/10.1002/hbm.24564

Metabolic markers of baseline brain oxygenation and tissue perfusion have an important role to play in the early identification of ischaemic tissue in acute stroke. Although well established MRI techniques exist for mapping brain perfusion, quantitat... Read More about Prospects for investigating brain oxygenation in acute stroke: experience with a non-contrast quantitative BOLD based approach.

Multiparametric measurement of cerebral physiology using calibrated fMRI (2017)
Journal Article
Bright, M. G., Croal, P. L., Blockley, N. P., & Bulte, D. P. (2019). Multiparametric measurement of cerebral physiology using calibrated fMRI. NeuroImage, 187, 128-144. https://doi.org/10.1016/j.neuroimage.2017.12.049

The ultimate goal of calibrated fMRI is the quantitative imaging of oxygen metabolism (CMRO2), and this has been the focus of numerous methods and approaches. However, one underappreciated aspect of this quest is that in the drive to measure CMRO2, m... Read More about Multiparametric measurement of cerebral physiology using calibrated fMRI.

Gas-free calibrated fMRI with a correction for vessel-size sensitivity (2017)
Journal Article
Berman, A. J., Mazerolle, E. L., MacDonald, M. E., Blockley, N. P., Luh, W., & Pike, G. B. (2018). Gas-free calibrated fMRI with a correction for vessel-size sensitivity. NeuroImage, 169, 176-188. https://doi.org/10.1016/j.neuroimage.2017.12.047

Calibrated functional magnetic resonance imaging (fMRI) is a method to independently measure the metabolic and hemodynamic contributions to the blood oxygenation level dependent (BOLD) signal. This technique typically requires the use of a respirator... Read More about Gas-free calibrated fMRI with a correction for vessel-size sensitivity.

Rapid cerebrovascular reactivity mapping: Enabling vascular reactivity information to be routinely acquired (2017)
Journal Article
Blockley, N. P., Harkin, J. W., & Bulte, D. P. (2017). Rapid cerebrovascular reactivity mapping: Enabling vascular reactivity information to be routinely acquired. NeuroImage, 159, 214-223. https://doi.org/10.1016/j.neuroimage.2017.07.048

Cerebrovascular reactivity mapping (CVR), using magnetic resonance imaging (MRI) and carbon dioxide as a stimulus, provides useful information on how cerebral blood vessels react under stress. This information has proven to be useful in the study of... Read More about Rapid cerebrovascular reactivity mapping: Enabling vascular reactivity information to be routinely acquired.