Skip to main content

Research Repository

Advanced Search

Outputs (6)

Screening Mutants by Single Fly Genomic PCR (2022)
Book Chapter
Nagarajan, U., & Georgiou, M. (2022). Screening Mutants by Single Fly Genomic PCR. In Notch Signaling Research (15-25). Humana Press. https://doi.org/10.1007/978-1-0716-2201-8_2

Imprecise P-element excision or FRT-mediated recombination is routinely performed to mutagenize a gene of interest. It is, however, tedious to maintain all independent and individual excised mutant fly lines before the presence of a mutation is confi... Read More about Screening Mutants by Single Fly Genomic PCR.

CG7379 and ING1 suppress cancer cell invasion by maintaining cell–cell junction integrity (2021)
Journal Article
Rusu, A. D., Cornhill, Z. E., Coutiño, B. C., Uribe, M. C., Lourdusamy, A., Markus, Z., …Georgiou, M. (2021). CG7379 and ING1 suppress cancer cell invasion by maintaining cell–cell junction integrity. Open Biology, 11(9), Article 210077. https://doi.org/10.1098/rsob.210077

Approximately 90% of cancer-related deaths can be attributed to a tumour's ability to spread. We have identified CG7379, the fly orthologue of human ING1, as a potent invasion suppressor. ING1 is a type II tumour suppressor with well-established role... Read More about CG7379 and ING1 suppress cancer cell invasion by maintaining cell–cell junction integrity.

In vivo Evaluation of a Newly Synthesized Acetylcholinesterase Inhibitor in a Transgenic Drosophila Model of Alzheimer’s Disease (2021)
Journal Article
Uras, G., Manca, A., Zhang, P., Markus, Z., Mack, N., Allen, S., …Zhu, Z. (2021). In vivo Evaluation of a Newly Synthesized Acetylcholinesterase Inhibitor in a Transgenic Drosophila Model of Alzheimer’s Disease. Frontiers in Neuroscience, 15, Article 691222. https://doi.org/10.3389/fnins.2021.691222

Alzheimer’s disease is a neurodegenerative disease characterized by disrupted memory, learning functions, reduced life expectancy, and locomotor dysfunction, as a result of the accumulation and aggregation of amyloid peptides that cause neuronal dama... Read More about In vivo Evaluation of a Newly Synthesized Acetylcholinesterase Inhibitor in a Transgenic Drosophila Model of Alzheimer’s Disease.

An apicobasal gradient of Rac activity determines protrusion form and position (2017)
Journal Article
Couto, A., Mack, N. A., Favia, L., & Georgiou, M. (2017). An apicobasal gradient of Rac activity determines protrusion form and position. Nature Communications, 8, Article 15385. https://doi.org/10.1038/ncomms15385

Each cell within a polarised epithelial sheet must align and correctly position a wide range of subcellular structures, including actin-based dynamic protrusions. Using in vivo inducible transgenes that can sense or modify Rac activity, we demonstrat... Read More about An apicobasal gradient of Rac activity determines protrusion form and position.

Glycosylated notch and cancer (2016)
Journal Article
Pakkiriswami, S., Couto, A., Nagarajan, U., & Georgiou, M. (2016). Glycosylated notch and cancer. Frontiers in Oncology, 6(37), https://doi.org/10.3389/fonc.2016.00037

Glycosylation is one of the key components influencing several signaling pathways implicated in cell survival and growth. The Notch signaling pathway plays a pivotal role in numerous cell fate specifications during metazoan development. Both Notch an... Read More about Glycosylated notch and cancer.

Contribution of Ref(2)p to regulation of Drosophila notum epithelial cell apico-basal polarity and phenotype (2015)
Conference Proceeding
Shohayeb, B., Georgiou, M., & Layfield, R. (2015). Contribution of Ref(2)p to regulation of Drosophila notum epithelial cell apico-basal polarity and phenotype.

Cell polarity impacts on the maintenance of cell shape, cell-cell junction integrity, and protrusion formation and dynamics. Further, polarity additionally regulates cell movement, proliferation and differentiation. Conversely when cells lose their p... Read More about Contribution of Ref(2)p to regulation of Drosophila notum epithelial cell apico-basal polarity and phenotype.