Outputs (27)

Age-related impact of social isolation in mice: Young vs middle-aged (2024)
Journal Article
Magalhães, D. M., Mampay, M., Sebastião, A. M., Sheridan, G. K., & Valente, C. A. (2024). Age-related impact of social isolation in mice: Young vs middle-aged. Neurochemistry International, 174, Article 105678. https://doi.org/10.1016/j.neuint.2024.105678

Social isolation is a chronic mild stressor and a significant risk factor for mental health disorders. Herein we explored the impact of social isolation on depression- and anxiety-like behaviours, as well as spatial memory impairments, in middle-aged... Read More about Age-related impact of social isolation in mice: Young vs middle-aged.

Emergent mechanical control of vascular morphogenesis (2023)
Journal Article
Whisler, J., Shahreza, S., Schlegelmilch, K., Ege, N., Javanmardi, Y., Malandrino, A., …Moeendarbary, E. (2023). Emergent mechanical control of vascular morphogenesis. Science Advances, 9(32), Article eadg9781. https://doi.org/10.1126/sciadv.adg9781

Vascularization is driven by morphogen signals and mechanical cues that coordinately regulate cellular force generation, migration, and shape change to sculpt the developing vascular network. However, it remains unclear whether developing vasculature... Read More about Emergent mechanical control of vascular morphogenesis.

Hippocampus of the APP NL–G–F mouse model of Alzheimer’s disease exhibits region-specific tissue softening concomitant with elevated astrogliosis (2023)
Journal Article
Hall, C. M., Lasli, S., Serwinski, B., Djordjevic, B., Sheridan, G. K., & Moeendarbary, E. (2023). Hippocampus of the APP NL–G–F mouse model of Alzheimer’s disease exhibits region-specific tissue softening concomitant with elevated astrogliosis. Frontiers in Aging Neuroscience, 15, Article 1212212. https://doi.org/10.3389/fnagi.2023.1212212

Widespread neurodegeneration, enlargement of cerebral ventricles, and atrophy of cortical and hippocampal brain structures are classic hallmarks of Alzheimer’s disease (AD). Prominent macroscopic disturbances to the cytoarchitecture of the AD brain o... Read More about Hippocampus of the APP NL–G–F mouse model of Alzheimer’s disease exhibits region-specific tissue softening concomitant with elevated astrogliosis.

Endothelium and Subendothelial Matrix Mechanics Modulate Cancer Cell Transendothelial Migration (2023)
Journal Article
Javanmardi, Y., Agrawal, A., Malandrino, A., Lasli, S., Chen, M., Shahreza, S., …Kamm, R. (2023). Endothelium and Subendothelial Matrix Mechanics Modulate Cancer Cell Transendothelial Migration. Advanced Science, 10(16), Article 2206554. https://doi.org/10.1002/advs.202206554

Cancer cell extravasation, a key step in the metastatic cascade, involves cancer cell arrest on the endothelium, transendothelial migration (TEM), followed by the invasion into the subendothelial extracellular matrix (ECM) of distant tissues. While c... Read More about Endothelium and Subendothelial Matrix Mechanics Modulate Cancer Cell Transendothelial Migration.

Poroelastic osmoregulation of living cell volume (2021)
Journal Article
Esteki, M. H., Malandrino, A., Alemrajabi, A. A., Sheridan, G. K., Charras, G., & Moeendarbary, E. (2021). Poroelastic osmoregulation of living cell volume. iScience, 24(12), Article 103482. https://doi.org/10.1016/j.isci.2021.103482

Cells maintain their volume through fine intracellular osmolarity regulation. Osmotic challenges drive fluid into or out of cells causing swelling or shrinkage, respectively. The dynamics of cell volume changes depending on the rheology of the cellul... Read More about Poroelastic osmoregulation of living cell volume.

Tumour brain: pre‐treatment cognitive and affective disorders caused by peripheral cancers (2021)
Journal Article
Mampay, M., Flint, M. S., & Sheridan, G. K. (2021). Tumour brain: pre‐treatment cognitive and affective disorders caused by peripheral cancers. British Journal of Pharmacology, 178(19), 3977-3996. https://doi.org/10.1111/bph.15571

People that develop extracranial cancers often display co-morbid neurological disorders, such as anxiety, depression and cognitive impairment, even before commencement of chemotherapy. This suggests bidirectional crosstalk between non-CNS tumours and... Read More about Tumour brain: pre‐treatment cognitive and affective disorders caused by peripheral cancers.

Extracellular Vesicles and Intercellular Communication in the Central Nervous System (2021)
Journal Article
Lizarraga?Valderrama, L. R., & Sheridan, G. K. (2021). Extracellular Vesicles and Intercellular Communication in the Central Nervous System. FEBS Letters, 595(10), 1391-1410. https://doi.org/10.1002/1873-3468.14074

Neurons and glial cells of the central nervous system (CNS) release extracellular vesicles (EVs) to the interstitial fluid of the brain and spinal cord parenchyma. EVs contain proteins, nucleic acids and lipids that can be taken up by, and modulate t... Read More about Extracellular Vesicles and Intercellular Communication in the Central Nervous System.

Spatiotemporal immunolocalisation of REST in the brain of healthy ageing and Alzheimer’s disease rats (2020)
Journal Article
Mampay, M., Velasco‐Estevez, M., Rolle, S. O., Chaney, A. M., Boutin, H., Dev, K. K., …Sheridan, G. K. (2021). Spatiotemporal immunolocalisation of REST in the brain of healthy ageing and Alzheimer’s disease rats. FEBS Open Bio, 11(1), 146-163. https://doi.org/10.1002/2211-5463.13036

In the brain, REST (Repressor Element‐1 Silencing Transcription factor) is a key regulator of neuron cell‐specific gene expression. Nuclear translocation of neuronal REST has been shown to be neuroprotective in a healthy ageing context. In contrast,... Read More about Spatiotemporal immunolocalisation of REST in the brain of healthy ageing and Alzheimer’s disease rats.

A new framework for characterization of poroelastic materials using indentation (2019)
Journal Article
Esteki, M. H., Alemrajabi, A. A., Hall, C., Sheridan, G. K., Azadi, M., & Moeendarbary, E. (2020). A new framework for characterization of poroelastic materials using indentation. Acta Biomaterialia, 102, 138-148. https://doi.org/10.1016/j.actbio.2019.11.010

To characterize a poroelastic material, typically an indenter is pressed onto the surface of the material with a ramp of a finite approach velocity followed by a hold where the indenter displacement is kept constant. This leads to deformation of the... Read More about A new framework for characterization of poroelastic materials using indentation.

Inhibition of Piezo1 attenuates demyelination in the central nervous system (2019)
Journal Article
Velasco‐Estevez, M., Gadalla, K. K. E., Liñan‐Barba, N., Cobb, S., Dev, K. K., & Sheridan, G. K. (2020). Inhibition of Piezo1 attenuates demyelination in the central nervous system. Glia, 68(2), 356-375. https://doi.org/10.1002/glia.23722

Piezo1 is a mechanosensitive ion channel that facilitates the translation of extracellular mechanical cues to intracellular molecular signaling cascades through a process termed, mechanotransduction. In the central nervous system (CNS), mechanically... Read More about Inhibition of Piezo1 attenuates demyelination in the central nervous system.