Outputs (47)

Swallow Tail Sign: Revisited (2022)
Journal Article
Brammerloh, M., Kirilina, E., Alkemade, A., Bazin, P.-L., Jantzen, C., Jäger, C., …Weiskopf, N. (2022). Swallow Tail Sign: Revisited. Radiology, 305(3), 674-677. https://doi.org/10.1148/radiol.212696

The loss of the radiologic swallow tail sign on MRI scans of the substantia nigra is a promising diagnostic marker of Parkinson disease (1), although its anatom-ic underpinning is unclear. An early influential study showed th... Read More about Swallow Tail Sign: Revisited.

Quantifiable correlation of ToF-SIMS and XPS data from polymer surfaces with controlled amino acid and peptide content (2022)
Journal Article
Taylor, M., Simoes, F., Smith, J., Genapathy, S., Canning, A., Lledos, M., …Zelzer, M. (2022). Quantifiable correlation of ToF-SIMS and XPS data from polymer surfaces with controlled amino acid and peptide content. Surface and Interface Analysis, 54(4), 417-432. https://doi.org/10.1002/sia.7052

Peptide-coated surfaces are widely employed in biomaterial design, but quantifiable correlation between surface composition and biological response is challenging due to, for example, instrumental limitations, a lack of suitable model surfaces or lim... Read More about Quantifiable correlation of ToF-SIMS and XPS data from polymer surfaces with controlled amino acid and peptide content.

Toward next-generation primate neuroscience: A collaboration-based strategic plan for integrative neuroimaging (2021)
Journal Article
PRIMatE Data and Resource Exchange (PRIME-DRE) Global Collaboration Workshop and Consortium, Milham, M., Petkov, C., Belin, P., Ben Hamed, S., Evrard, H., …Zuo, Z. (2022). Toward next-generation primate neuroscience: A collaboration-based strategic plan for integrative neuroimaging. Neuron, 110(1), 16-20. https://doi.org/10.1016/j.neuron.2021.10.015

Open science initiatives are creating opportunities to increase research coordination and impact in nonhuman primate (NHP) imaging. The PRIMatE Data and Resource Exchange community recently developed a collaboration-based strategic plan to advance NH... Read More about Toward next-generation primate neuroscience: A collaboration-based strategic plan for integrative neuroimaging.

Sulcal characteristics patterns and gyrification gradient at different stages of Anorexia Nervosa: a structural MRI evaluation (2021)
Journal Article
Collantoni, E., Madan, C. R., Meregalli, V., Meneguzzo, P., Marzola, E., Panero, M., …Favaro, A. (2021). Sulcal characteristics patterns and gyrification gradient at different stages of Anorexia Nervosa: a structural MRI evaluation. Psychiatry Research: Neuroimaging, 316, Article 111350. https://doi.org/10.1016/j.pscychresns.2021.111350

Previous research evidenced alterations of different cortical parameters in patients with acute Anorexia Nervosa (AN), but no study to date investigated the morphology of individual sulci and their relationship with other structural indices. Our stud... Read More about Sulcal characteristics patterns and gyrification gradient at different stages of Anorexia Nervosa: a structural MRI evaluation.

T2 heterogeneity as an in vivo marker of microstructural integrity in medial temporal lobe subfields in ageing and mild cognitive impairment (2021)
Journal Article
Wearn, A. R., Nurdal, V., Saunders-Jennings, E., Knight, M. J., Madan, C. R., Fallon, S., …Coulthard, E. J. (2021). T2 heterogeneity as an in vivo marker of microstructural integrity in medial temporal lobe subfields in ageing and mild cognitive impairment. NeuroImage, 238, Article 118214. https://doi.org/10.1016/j.neuroimage.2021.118214

A better understanding of early brain changes that precede loss of independence in diseases like Alzheimer's disease (AD) is critical for development of disease-modifying therapies. Quantitative MRI, such as T2 relaxometry, can identify microstructur... Read More about T2 heterogeneity as an in vivo marker of microstructural integrity in medial temporal lobe subfields in ageing and mild cognitive impairment.

Beyond volumetry: Considering age-related changes in brain shape complexity using fractal dimensionality (2021)
Journal Article
Madan, C. R. (2021). Beyond volumetry: Considering age-related changes in brain shape complexity using fractal dimensionality. Aging Brain, 1, Article 100016. https://doi.org/10.1016/j.nbas.2021.100016

Gray matter volume for cortical, subcortical, and ventricles all vary with age. However, these volumetric changes do not happen on their own, there are also age-related changes in cortical folding and other measures of brain shape. Fractal dimensiona... Read More about Beyond volumetry: Considering age-related changes in brain shape complexity using fractal dimensionality.

Scan Once, Analyse Many: Using large open-access neuroimaging datasets to understand the brain (2021)
Journal Article
Madan, C. R. (2022). Scan Once, Analyse Many: Using large open-access neuroimaging datasets to understand the brain. Neuroinformatics, 20, 109-137. https://doi.org/10.1007/s12021-021-09519-6

We are now in a time of readily available brain imaging data. Not only are researchers now sharing data more than ever before, but additionally large-scale data collecting initiatives are underway with the vision that many future researchers will use... Read More about Scan Once, Analyse Many: Using large open-access neuroimaging datasets to understand the brain.

Investigating the effects of healthy cognitive aging on brain functional connectivity using 4.7 T resting-state functional Magnetic Resonance Imaging (2021)
Journal Article
Hrybouski, S., Cribben, I., McGonigle, J., Olsen, F., Carter, R., Seres, P., …Malykhin, N. V. (2021). Investigating the effects of healthy cognitive aging on brain functional connectivity using 4.7 T resting-state functional Magnetic Resonance Imaging. Brain Structure and Function, 226(4), 1067-1098. https://doi.org/10.1007/s00429-021-02226-7

Functional changes in the aging human brain have been previously reported using functional magnetic resonance imaging (fMRI). Earlier resting-state fMRI studies revealed an age-associated weakening of intra-system functional connectivity (FC) and age... Read More about Investigating the effects of healthy cognitive aging on brain functional connectivity using 4.7 T resting-state functional Magnetic Resonance Imaging.

Age‐related decrements in cortical gyrification: Evidence from an accelerated longitudinal dataset (2020)
Journal Article
Madan, C. R. (2021). Age‐related decrements in cortical gyrification: Evidence from an accelerated longitudinal dataset. European Journal of Neuroscience, 53(5), 1661-1671. https://doi.org/10.1111/ejn.15039

Cortical gyrification has been found to decrease due to aging, but thus far this has only been examined in cross‐sectional samples. Interestingly, the topography of these age‐related differences in gyrification follows a distinct gradient along the c... Read More about Age‐related decrements in cortical gyrification: Evidence from an accelerated longitudinal dataset.

Structural complexity is negatively associated with brain activity: a novel multimodal test of compensation theories of aging (2020)
Journal Article
McDonough, I. M., & Madan, C. R. (2021). Structural complexity is negatively associated with brain activity: a novel multimodal test of compensation theories of aging. Neurobiology of Aging, 98, 185-196. https://doi.org/10.1016/j.neurobiolaging.2020.10.023

Fractal dimensionality (FD) measures the complexity within the folds and ridges of cortical and subcortical structures. We tested the degree that FD might provide a new perspective on the atrophy-compensation hypothesis: age or disease-related atroph... Read More about Structural complexity is negatively associated with brain activity: a novel multimodal test of compensation theories of aging.

XTRACT - Standardised protocols for automated tractography in the human and macaque brain (2020)
Journal Article
Warrington, S., Bryant, K. L., Khrapitchev, A. A., Sallet, J., Charquero-Ballester, M., Douaud, G., …Sotiropoulos, S. N. (2020). XTRACT - Standardised protocols for automated tractography in the human and macaque brain. NeuroImage, 217, Article 116923. https://doi.org/10.1016/j.neuroimage.2020.116923

We present a new software package with a library of standardised tractography protocols devised for the robust automated extraction of white matter tracts both in the human and the macaque brain. Using in vivo data from the Human Connectome Project (... Read More about XTRACT - Standardised protocols for automated tractography in the human and macaque brain.

Operando visualisation of battery chemistry in a sodium-ion battery by 23Na magnetic resonance imaging (2020)
Journal Article
Kendrick, E., Bray, J. M., Doswell, C. L., Pavlovskaya, G. E., Chen, L., Kishore, B., …Britton, M. M. (2020). Operando visualisation of battery chemistry in a sodium-ion battery by 23Na magnetic resonance imaging. Nature Communications, 11(1), Article 2083. https://doi.org/10.1038/s41467-020-15938-x

© 2020, The Author(s). Sodium-ion batteries are a promising battery technology for their cost and sustainability. This has led to increasing interest in the development of new sodium-ion batteries and new analytical methods to non-invasively, directl... Read More about Operando visualisation of battery chemistry in a sodium-ion battery by 23Na magnetic resonance imaging.

Cortical Complexity in Anorexia Nervosa: A Fractal Dimension Analysis (2020)
Journal Article
Collantoni, E., Madan, C. R., Meneguzzo, P., Chiappini, I., Tenconi, E., Manara, R., & Favaro, A. (2020). Cortical Complexity in Anorexia Nervosa: A Fractal Dimension Analysis. Journal of Clinical Medicine, 9(3), 833. https://doi.org/10.3390/jcm9030833

Fractal Dimension (FD) has shown to be a promising means to describe the morphology of cortical structures across different neurologic and psychiatric conditions, displaying a good sensitivity in capturing atrophy processes. In this study, we aimed a... Read More about Cortical Complexity in Anorexia Nervosa: A Fractal Dimension Analysis.

A Population-based PBPK Model for the Prediction of Time-Variant Bile Salt Disposition within GI Luminal Fluids (2020)
Journal Article
Stamatopoulos, K., Pathak, S., Marciani, L., & Turner, D. (2020). A Population-based PBPK Model for the Prediction of Time-Variant Bile Salt Disposition within GI Luminal Fluids. Molecular Pharmaceutics, 17(4), 1310-1323. https://doi.org/10.1021/acs.molpharmaceut.0c00019

In vivo studies have shown cyclic bile salt (BS) outputs during fasting whereas higher amounts have been observed in fed states. This leads to fluctuations of intestinal BS concentrations ([BS]) that can affect the rate and extent of absorption of li... Read More about A Population-based PBPK Model for the Prediction of Time-Variant Bile Salt Disposition within GI Luminal Fluids.

A simple and efficient method for polymer coating of iron oxide nanoparticles (2019)
Journal Article
Abushrida, A., Elhuni, I., Taresco, V., Marciani, L., Stolnik, S., & Garnett, M. C. (2020). A simple and efficient method for polymer coating of iron oxide nanoparticles. Journal of Drug Delivery Science and Technology, 55, Article 101460. https://doi.org/10.1016/j.jddst.2019.101460

Iron oxide nanoparticles (IONP) have many possible uses including as MRI contrast agents, for drug delivery and cell labelling, but need to be stabilised and to be rendered biocompatible through appropriate coatings. Many current coatings are subopti... Read More about A simple and efficient method for polymer coating of iron oxide nanoparticles.

Mechanisms and Risk Factors Contributing to Visual Field Deficits following Stereotactic Laser Amygdalohippocampotomy (2019)
Journal Article
Voets, N. L., Alvarez, I., Qiu, D., Leatherday, C., Willie, J. T., Sotiropoulos, S., …Drane, D. L. (2019). Mechanisms and Risk Factors Contributing to Visual Field Deficits following Stereotactic Laser Amygdalohippocampotomy. Stereotactic and Functional Neurosurgery, 97(4), 255–265. https://doi.org/10.1159/000502701

Selective laser amygdalohippocampotomy (SLAH) is a minimally invasive surgical treatment for medial temporal lobe epilepsy. Visual field deficits (VFDs) are a significant potential complication. The objective of this study was to determine the relati... Read More about Mechanisms and Risk Factors Contributing to Visual Field Deficits following Stereotactic Laser Amygdalohippocampotomy.

Short-range ordering in a battery electrode, the ‘cation-disordered’ rocksalt Li1.25Nb0.25Mn0.5O2 (2019)
Journal Article
Jones, M. A., Reeves, P. J., Seymour, I. D., Cliffe, M. J., Dutton, S. E., & Grey, C. P. (2019). Short-range ordering in a battery electrode, the ‘cation-disordered’ rocksalt Li1.25Nb0.25Mn0.5O2. Chemical Communications, 55(61), 9027-9030. https://doi.org/10.1039/c9cc04250d

Cation order, with a local structure related to γ-LiFeO2, is observed in the nominally cation-disordered Li-excess rocksalt Li1.25Nb0.25Mn0.5O2via X-ray diffraction, neutron pair distribution function analysis, magnetic susceptibility and NMR spectro... Read More about Short-range ordering in a battery electrode, the ‘cation-disordered’ rocksalt Li1.25Nb0.25Mn0.5O2.

Prediction of Stroke Risk by Detection of Hemorrhage in Carotid Plaques: Meta-Analysis of Individual Patient Data (2019)
Journal Article
Schindler, A., Schinner, R., Altaf, N., Hosseini, A. A., Simpson, R. J., Esposito-Bauer, L., …Saam, T. (2019). Prediction of Stroke Risk by Detection of Hemorrhage in Carotid Plaques: Meta-Analysis of Individual Patient Data. JACC: Cardiovascular Imaging, 13(2), 395-406. https://doi.org/10.1016/j.jcmg.2019.03.028

Objectives
The goal of this study was to compare the risk of stroke between patients with carotid artery disease with and without the presence of intraplaque hemorrhage (IPH) on magnetic resonance imaging.

Background
IPH in carotid stenosis incr... Read More about Prediction of Stroke Risk by Detection of Hemorrhage in Carotid Plaques: Meta-Analysis of Individual Patient Data.

Robust estimation of sulcal morphology (2019)
Journal Article
Madan, C. R. (2019). Robust estimation of sulcal morphology. Brain Informatics, 6, Article 5. https://doi.org/10.1186/s40708-019-0098-1

While it is well established that cortical morphology differs in relation to a variety of inter-individual factors, it is often characterized using estimates of volume, thickness, surface area, or gyrification. Here we developed a computational appro... Read More about Robust estimation of sulcal morphology.

Data visualization for inference in tomographic brain imaging (2019)
Journal Article
Pernet, C. R., & Madan, C. R. (2020). Data visualization for inference in tomographic brain imaging. European Journal of Neuroscience, 51(3), 695-705. https://doi.org/10.1111/ejn.14430

Tomographic brain imaging has a rich iconography. Whilst figures are prepared for scientific communication (i.e., directed to other researchers) they also often end-up on magazine and journal covers (i.e., directed to a lay audience). Scientific figu... Read More about Data visualization for inference in tomographic brain imaging.