GURUPRASAD AITHAL's Outputs (5)

Association of liver injury from specific drugs, or groups of drugs, with polymorphisms in HLA and other genes in a genome-wide association study (2016)
Journal Article
Nicoletti, P., Aithal, G. P., Bjornsson, E. S., Andrade, R. J., Sawle, A., Arrese, M., …Daly, A. K. (2017). Association of liver injury from specific drugs, or groups of drugs, with polymorphisms in HLA and other genes in a genome-wide association study. Gastroenterology, 152(5), 1078-1089. https://doi.org/10.1053/j.gastro.2016.12.016

Background & aims: We performed a genome-wide association study (GWAS) to identify genetic risk factors for drug-induced liver injury (DILI) from licensed drugs without previously reported genetic risk factors.
Methods: We performed a GWAS of 862 pe... Read More about Association of liver injury from specific drugs, or groups of drugs, with polymorphisms in HLA and other genes in a genome-wide association study.

Non-invasive assessment of portal hypertension using quantitative magnetic resonance imaging (2016)
Journal Article
Palaniyappan, N., Cox, E., Bradley, C., Scott, R., Austin, A., O’Neill, R., Ramjas, G., Travis, S., White, H., Singh, R., Thurley, P., Guha, I. N., Francis, S., & Aithal, G. P. (2016). Non-invasive assessment of portal hypertension using quantitative magnetic resonance imaging. Journal of Hepatology, 65(6), 1131-1139. https://doi.org/10.1016/j.jhep.2016.07.021

Background & Aims

Hepatic venous pressure gradient (HVPG) measurement is currently the only validated technique to accurately evaluate changes in portal pressure. In this study, we evaluate the use of non-contrast quantitative magnetic resonance i... Read More about Non-invasive assessment of portal hypertension using quantitative magnetic resonance imaging.

Immune dysfunction in patients with obstructive jaundice before and after endoscopic retrograde cholangiopancreatography (2016)
Journal Article
Chowdhury, A. H., Camara, M., Martinez-Pomares, L., Zaitoun, A. M., Eremin, O., Aithal, G. P., & Lobo, D. (2016). Immune dysfunction in patients with obstructive jaundice before and after endoscopic retrograde cholangiopancreatography. Clinical Science, 130(17), 1535-1544. https://doi.org/10.1042/CS20160326

© 2016 The Author(s). This prospective observational study investigated monocyte cytokine responses to lipopolysaccharide (LPS) in patients with obstructive jaundice (OJ) before and after endoscopic biliary drainage. Dendritic cell (DC) subsets and t... Read More about Immune dysfunction in patients with obstructive jaundice before and after endoscopic retrograde cholangiopancreatography.

The detection of oesophageal varices using a novel, disposable, probe-based transnasal endoscope: a prospective diagnostic pilot study (2016)
Journal Article

Background & Aims
Screening for oesophageal varices (OV) using conventional oesophagogastroduodenoscopy (C-OGD) is invasive and requires costly monitoring, recovery, and decontamination facilities. We aimed to evaluate the technical feasibility, acc... Read More about The detection of oesophageal varices using a novel, disposable, probe-based transnasal endoscope: a prospective diagnostic pilot study.

Monozygotic twins with NASH cirrhosis: cumulative effect of multiple single nucleotide polymorphisms? (2016)
Journal Article
Grove, J. I., Austin, M., Tibble, J., Aithal, G. P., & Verma, S. (2016). Monozygotic twins with NASH cirrhosis: cumulative effect of multiple single nucleotide polymorphisms?. Annals of Hepatology, 15(2), 277-282

Multiple genetic and environmental factors interact to determine an individual’s predisposition to non-alcoholic fatty liver disease and its phenotypic characteristics. Association studies have found a number of alleles associated with the developmen... Read More about Monozygotic twins with NASH cirrhosis: cumulative effect of multiple single nucleotide polymorphisms?.