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All Outputs (117)

Controversies in acute medicine: Oxygen therapy for exacerbations of chronic obstructive pulmonary disease (COPD) (2004)
Journal Article
Cooper, N. (2004). Controversies in acute medicine: Oxygen therapy for exacerbations of chronic obstructive pulmonary disease (COPD). Acute Medicine, 3(2), 45-84. https://doi.org/10.52964/AMJA.0071

Some patients with COPD ‘retain CO2’ when given high concentration or uncontrolled oxygen therapy. The mechanism for this, and why it occurs in only some patients, is unclear. The pathogenesis of chronic hypercapnia in COPD involves multiple, poorly... Read More about Controversies in acute medicine: Oxygen therapy for exacerbations of chronic obstructive pulmonary disease (COPD).

Organisational learning in a political environment: Improving policy-making in UK government (2004)
Journal Article
Common, R. (2004). Organisational learning in a political environment: Improving policy-making in UK government. Policy Studies, 25(1), 35-49. https://doi.org/10.1080/0144287042000208224

This article observes that the political environment will always compromise the application of the organisational learning concept in government. In an attempt to overcome this problem, it seeks to demonstrate that a conceptual synthesis between poli... Read More about Organisational learning in a political environment: Improving policy-making in UK government.

Long-Term Care: Matching Resources and Needs (2004)
Book
Knapp, M., Challis, D., Fernández, J.-L., & Netten, A. (Eds.). (2004). Long-Term Care: Matching Resources and Needs. Routledge. https://doi.org/10.4324/9781351153560

Improving equity and efficiency in the long-term care of older people is an international concern, with governments attempting to ensure that policies and practice develop so that resources are used to best effect. This requires good quality evidence... Read More about Long-Term Care: Matching Resources and Needs.

Cl− Influx into Rat Cortical Lens Fiber Cells Is Mediated by a Cl− Conductance That Is Not ClC-2 or -3 (2004)
Journal Article
Webb, K. F., Merriman-Smith, B. R., Stobie, J. K., Kistler, J., & Donaldson, P. J. (2004). Cl− Influx into Rat Cortical Lens Fiber Cells Is Mediated by a Cl− Conductance That Is Not ClC-2 or -3. Investigative Ophthalmology & Visual Science, 45(12), 4400-4408. https://doi.org/10.1167/iovs.04-0205

PURPOSE. Exposure of organ-cultured lenses to C1- channel blockers under isotonic conditions induces a localized cortical zone of extracellular space dilations. The purpose of this study was to investigate whether elongated lens fiber cells from this... Read More about Cl− Influx into Rat Cortical Lens Fiber Cells Is Mediated by a Cl− Conductance That Is Not ClC-2 or -3.

Immune System Approaches to Intrusion Detection - A Review (ICARIS) (2004)
Presentation / Conference Contribution
Aickelin, U., Greensmith, J., & Twycross, J. (2004, September). Immune System Approaches to Intrusion Detection - A Review (ICARIS). Presented at Artificial Immune Systems, Sicily, Italy

The use of artificial immune systems in intrusion detection is an appealing concept for two reasons. Firstly, the human immune system provides the human body with a high level of protection from invading pathogens, in a robust, self-organised and dis... Read More about Immune System Approaches to Intrusion Detection - A Review (ICARIS).

Uranyl-citrate speciation in acidic aqueous solutions - An XAS study between 25 and 200 °C (2004)
Journal Article
Bailey, E. H., Mosselmans, J. F., & Schofield, P. F. (2005). Uranyl-citrate speciation in acidic aqueous solutions - An XAS study between 25 and 200 °C. Chemical Geology, 216(1-2), 1-16. https://doi.org/10.1016/j.chemgeo.2004.10.011

Speciation of uranium(VI) in citrate (2-hydroxypropane-1,2, 3-tricarboxylic acid) solutions between 25 and 200 °C, at pH values between 0.8 and 3.7 and at citrate/U ratios between 0.5 and 50 has been investigated using U LIII-edge X-ray absorption sp... Read More about Uranyl-citrate speciation in acidic aqueous solutions - An XAS study between 25 and 200 °C.

Organ-specificity, colonization and clearance dynamics in vivo following oral challenges with the murine pathogen Citrobacter rodentium (2004)
Journal Article
Wiles, S., Clare, S., Harker, J., Huett, A., Young, D., Dougan, G., & Frankel, G. (2004). Organ-specificity, colonization and clearance dynamics in vivo following oral challenges with the murine pathogen Citrobacter rodentium. Cellular Microbiology, 7(3), 459. https://doi.org/10.1111/j.1462-5822.2004.00479.x

In the article by Wiles et al. (2004) the wild-type Citrobacter rodentium (and naladixic acid-resistant derivative) strain used was not David Schauer's DBS100 (Schauer et al., 1993) but ICC168 which is a wild-type strain (formally Citrobacter freundi... Read More about Organ-specificity, colonization and clearance dynamics in vivo following oral challenges with the murine pathogen Citrobacter rodentium.

Molecular tagging of a senescence gene by introgression mapping of a stay-green mutation from Festuca pratensis (2004)
Journal Article
Moore, B. J., Donnison, I. S., Harper, J. A., Armstead, I. P., King, J., Thomas, H., Jones, R. N., Jones, T. H., Thomas, H. M., Morgan, W. G., Thomas, A., Ougham, H. J., Huang, L., Fentem, T., Roberts, L. A., & King, I. P. (2005). Molecular tagging of a senescence gene by introgression mapping of a stay-green mutation from Festuca pratensis. New Phytologist, 165(3), 801-806. https://doi.org/10.1111/j.1469-8137.2004.01269.x

Intergeneric hybrids between Lolium multiflorum and Festuca pratensis (Lm/Fp) and their derivatives exhibit a unique combination of genetic and cytogenetic characteristics: chromosomes undergo a high frequency of homoeologous recombination at meiosis... Read More about Molecular tagging of a senescence gene by introgression mapping of a stay-green mutation from Festuca pratensis.

The Sparta and the Athens Of Our Age At Daggers Drawn: Polities, Perceptions, and Peace (2004)
Journal Article
Rendall, M. (2004). The Sparta and the Athens Of Our Age At Daggers Drawn: Polities, Perceptions, and Peace. International Politics, 41(4),

While historically notions of democracy have varied widely, democratic peace theory has generally defined it in procedural terms. This article takes a close look at the Anglo-French confrontation of 1840. I show that while leaders on both sides were... Read More about The Sparta and the Athens Of Our Age At Daggers Drawn: Polities, Perceptions, and Peace.

Steroid-estrogen determination in sediment and sewage sludge: A critique of sample preparation and chromatographic/mass spectrometry considerations, incorporating a case study in method development (2004)
Journal Article
Gomes, R. L., Avcioglu, E., Scrimshaw, M. D., & Lester, J. N. (2004). Steroid-estrogen determination in sediment and sewage sludge: A critique of sample preparation and chromatographic/mass spectrometry considerations, incorporating a case study in method development. Trends in Analytical Chemistry, 23(10-11), 737-744. https://doi.org/10.1016/j.trac.2004.08.006

Calixthe Beyala: black face(s) on French TV (2004)
Journal Article
Hitchcott, N. (2004). Calixthe Beyala: black face(s) on French TV. Modern and Contemporary France, 12(4), https://doi.org/10.1080/0963948042000284731

As president and spokeswoman of the French black rights movement, Collectif Egalité, Cameroonian-born novelist Calixthe Beyala is committed to pushing for an improvement in the representation of black people on television in France. This article disc... Read More about Calixthe Beyala: black face(s) on French TV.

Herpes simplex virus VP22-human papillomavirus E2 fusion proteins produced in mammalian or bacterial cells enter mammalian cells and induce apoptotic cell death (2004)
Journal Article
Roeder, G. E., Parish, J. L., Stern, P. L., & Gaston, K. (2004). Herpes simplex virus VP22-human papillomavirus E2 fusion proteins produced in mammalian or bacterial cells enter mammalian cells and induce apoptotic cell death. Biotechnology and Applied Biochemistry, 40(2), 157-165. https://doi.org/10.1042/BA20030172

Infection by high‐risk HPV (human papillomavirus) is supposed to be the primary cause of cervical cancer. The HPV E2 protein (E2) is a DNA‐binding protein that regulates viral gene expression and is required for efficient viral replication. Overexpre... Read More about Herpes simplex virus VP22-human papillomavirus E2 fusion proteins produced in mammalian or bacterial cells enter mammalian cells and induce apoptotic cell death.

Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient mice (2004)
Journal Article
Li, C. K., Pender, S. L., Pickard, K. M., Chance, V., Holloway, J. A., Huett, A., Gonçalves, N. S., Mudgett, J. S., Dougan, G., Frankel, G., & MacDonald, T. T. (2004). Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient mice. Journal of Immunology, 173(8), 5171-5179. https://doi.org/10.4049/jimmunol.173.8.5171

Infection of mice with the intestinal bacterial pathogen Citrobacter rodentium results in colonic mucosal hyperplasia and a local Th1 inflammatory response similar to that seen in mouse models of inflammatory bowel disease. Matrix metalloproteinases... Read More about Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient mice.

A diagnosis not to miss (2004)
Journal Article
Garside, M., James, R., & Cooper, N. (2004). A diagnosis not to miss. British Journal of Hospital Medicine, 65(10), 628-629. https://doi.org/10.12968/hosp.2004.65.10.16619

A 45-year-old woman attended accident and emergency after fainting and feeling unwell with a fever. Blood and protein were noted in the urine. A diagnosis of urinary tract infection was made and she was sent home with antibiotics. She became increasi... Read More about A diagnosis not to miss.

Activity profile of dust mite allergen extract using substrate libraries and functional proteomic microarrays (2004)
Journal Article
Harris, J., Mason, D. E., Li, J., Burdick, K. W., Backes, B. J., Chen, T., Shipway, A., Van Heeke, G., Gough, L., Ghaemmaghami, A., Shakib, F., Debaene, F., & Winssinger, N. (2004). Activity profile of dust mite allergen extract using substrate libraries and functional proteomic microarrays. Cell Chemical Biology, 11(10), 1361-1372. https://doi.org/10.1016/j.chembiol.2004.08.008

Enzymatic activity in the fecal droppings from the house dust mite has been postulated to contribute to the elicited allergic response. Screening dust mite extracts through 137,180 tetrapeptide fluorogenic substrates allowed for the characterization... Read More about Activity profile of dust mite allergen extract using substrate libraries and functional proteomic microarrays.