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Case Series: Efficacy of polyclonal intravenous immunoglobulin for refractory Clostridioides difficile infection (2024)
Journal Article
Monaghan, T., & Mahida, Y. (in press). Case Series: Efficacy of polyclonal intravenous immunoglobulin for refractory Clostridioides difficile infection. Antibodies,

Background: Intravenous immunoglobulin (IVIg) for Clostridioides difficile infection (CDI) no longer features in treatment guidelines. However, IVIg is still used by some clinicians for severe or recurrent CDI (rCDI) cases. The main objective of this... Read More about Case Series: Efficacy of polyclonal intravenous immunoglobulin for refractory Clostridioides difficile infection.

Protective effects of fecal microbiota transplantation against ischemic stroke and other neurological disorders: an update (2024)
Journal Article
Hediyal, T. A., Vichitra, C., Anand, N., Bhaskaran, M., Essa, S. M., Kumar, P., …Chidambaram, S. B. (2024). Protective effects of fecal microbiota transplantation against ischemic stroke and other neurological disorders: an update. Frontiers in Immunology, 15, Article 1324018. https://doi.org/10.3389/fimmu.2024.1324018

The bidirectional communication between the gut and brain or gut-brain axis is regulated by several gut microbes and microbial derived metabolites, such as short-chain fatty acids, trimethylamine N-oxide, and lipopolysaccharides. The Gut microbiota (... Read More about Protective effects of fecal microbiota transplantation against ischemic stroke and other neurological disorders: an update.

Sleep apnoea, gut dysbiosis and cognitive dysfunction (2023)
Journal Article
Deyang, T., Baig, A. I., Dolkar, P., Hediyal, T. A., Rathipriya, A. G., Bhaskaran, M., …Chidambaram, S. B. (2023). Sleep apnoea, gut dysbiosis and cognitive dysfunction. FEBS Journal, https://doi.org/10.1111/febs.16960

Sleep disorders are becoming increasingly common, and their distinct effects on physical and mental health require elaborate investigation. Gut dysbiosis (GD) has been reported in sleep-related disorders, but sleep apnoea is of particular significanc... Read More about Sleep apnoea, gut dysbiosis and cognitive dysfunction.

Gut microbiome-based dietary intervention in Parkinson disease subject: A case report (2023)
Journal Article
Sulthana, A., Paneyala, S., Narayan, M. K., Ahmed Hediyal, T., Sharma, S., Senthilkumar, A., …Sulakhe, D. (2023). Gut microbiome-based dietary intervention in Parkinson disease subject: A case report. International Journal of Nutrition, Pharmacology, Neurological Diseases, 13(3), 158-165. https://doi.org/10.4103/ijnpnd.ijnpnd_8_23

A 54-year-old woman was seeking medical treatment for Parkinson disease (PD) in the neurology outpatient department in JSS Hospital, Mysore, India. She was challenged in terms of reduced mobility and had sought several treatment options to control he... Read More about Gut microbiome-based dietary intervention in Parkinson disease subject: A case report.

MicroRNA-based therapeutics for inflammatory disorders of the microbiota-gut-brain axis (2023)
Journal Article
Datta, N., Johnson, C., Kao, D., Gurnani, P., Alexander, C., Polytarchou, C., & Monaghan, T. M. (2023). MicroRNA-based therapeutics for inflammatory disorders of the microbiota-gut-brain axis. Pharmacological Research, 194, Article 106870. https://doi.org/10.1016/j.phrs.2023.106870

An emerging but less explored shared pathophysiology across microbiota-gut-brain axis disorders is aberrant miRNA expression, which may represent novel therapeutic targets. miRNAs are small, endogenous non-coding RNAs that are important transcription... Read More about MicroRNA-based therapeutics for inflammatory disorders of the microbiota-gut-brain axis.

Beneficial effects of fecal microbiota transplantation in recurrent Clostridioides difficile infection (2023)
Journal Article
Yadegar, A., Pakpoor, S. F., Ibrahim, F. F., Nabavi-Rad, A., Cook, L., Walter, J., …Kao, D. (2023). Beneficial effects of fecal microbiota transplantation in recurrent Clostridioides difficile infection. Cell Host and Microbe, 31(5), 695-711. https://doi.org/10.1016/j.chom.2023.03.019

Fecal microbiota transplantation (FMT) is highly effective in preventing recurrent Clostridioides difficile infection (rCDI). However, the mechanisms underpinning its clinical efficacy are incompletely understood. Herein, we provide an overview of rC... Read More about Beneficial effects of fecal microbiota transplantation in recurrent Clostridioides difficile infection.

RNA-Seq of untreated wastewater to assess COVID-19 and emerging and endemic viruses for public health surveillance (2023)
Journal Article
Stockdale, S. R., Blanchard, A. M., Nayak, A., Husain, A., Nashine, R., Dudani, H., …Monaghan, T. M. (2023). RNA-Seq of untreated wastewater to assess COVID-19 and emerging and endemic viruses for public health surveillance. The Lancet Regional Health – Southeast Asia, 14, Article 100205. https://doi.org/10.1016/j.lansea.2023.100205

Background: The COVID-19 pandemic showcased the power of genomic sequencing to tackle the emergence and spread of infectious diseases. However, metagenomic sequencing of total microbial RNAs in wastewater has the potential to assess multiple infectio... Read More about RNA-Seq of untreated wastewater to assess COVID-19 and emerging and endemic viruses for public health surveillance.

The synergistic effect of Levilactobacillus breves IBRC-M10790 and vitamin D3 on Helicobacter pylori-induced inflammation (2023)
Journal Article
Nabavi-Rad, A., Jamshidizadeh, S., Azizi, M., Yadegar, A., Robinson, K., Monaghan, T. M., & Reza Zali, M. (2023). The synergistic effect of Levilactobacillus breves IBRC-M10790 and vitamin D3 on Helicobacter pylori-induced inflammation. Frontiers in Cellular and Infection Microbiology, 13, Article 1171469

Owing to the emergence and spread of multidrug resistance mechanisms in Helicobacter pylori, achieving a successful eradication has become exceedingly difficult. Thus, this study for the first time determines the effect of a combination of vitamin D3... Read More about The synergistic effect of Levilactobacillus breves IBRC-M10790 and vitamin D3 on Helicobacter pylori-induced inflammation.

Microbial-Immune Crosstalk in Elderly-Onset Inflammatory Bowel Disease: Unchartered Territory (2023)
Journal Article
Meng, G., Monaghan, T. M., Duggal, N. A., Tighe, P., & Peerani, F. (2023). Microbial-Immune Crosstalk in Elderly-Onset Inflammatory Bowel Disease: Unchartered Territory. Journal of Crohn's and Colitis, 17(8), 1309-1325. https://doi.org/10.1093/ecco-jcc/jjad025

Elderly-onset inflammatory bowel disease [IBD] patients exhibit a distinct natural history compared to younger IBD patients, with unique disease phenotypes, differential responses to therapy, and increased surgical morbidity and mortality. Despite th... Read More about Microbial-Immune Crosstalk in Elderly-Onset Inflammatory Bowel Disease: Unchartered Territory.

Plant-Derived Products with Therapeutic Potential against Gastrointestinal Bacteria (2023)
Journal Article
Qassadi, F. I., Zhu, Z., & Monaghan, T. M. (2023). Plant-Derived Products with Therapeutic Potential against Gastrointestinal Bacteria. Pathogens, 12(2), Article 333. https://doi.org/10.3390/pathogens12020333

The rising burden of antimicrobial resistance and increasing infectious disease outbreaks, including the recent COVID-19 pandemic, has led to a growing demand for the development of natural products as a valuable source of leading medicinal compounds... Read More about Plant-Derived Products with Therapeutic Potential against Gastrointestinal Bacteria.

Therapeutic potential of miRNAs in Clostridioides difficile infection (2022)
Journal Article
Monaghan, T. M., Polytarchou, C., Kao, D., Alexander, C., & Gurnani, P. (2022). Therapeutic potential of miRNAs in Clostridioides difficile infection. Future Microbiology, 17(5), 315-318. https://doi.org/10.2217/fmb-2021-0311

Treating Clostridioides difficile infection with miRNAs alone or combined with live biotherapeutic products may augment therapeutic efficacy and help counteract drug resistance in the future.

Clostridioides difficile epidemiology in India (2022)
Journal Article
Monaghan, T. M., Biswas, R., Satav, A., Ambalkar, S., & Kashyap, R. S. (2022). Clostridioides difficile epidemiology in India. Anaerobe, 74, Article 102517. https://doi.org/10.1016/j.anaerobe.2022.102517

Clostridioides difficile infection (CDI) continues to affect hospitalized patients and community populations worldwide. In contrast to the substantial resources invested in the diagnosis and prevention of CDI in high-income countries, this anaerobic... Read More about Clostridioides difficile epidemiology in India.

Clostridioides difficile: innovations in target discovery and potential for therapeutic success (2021)
Journal Article
Monaghan, T. M., Seekatz, A. M., Mullish, B. H., Moore-Gillon, C. E., Dawson, L., Ahmed, A., …Chan, W. C. (2021). Clostridioides difficile: innovations in target discovery and potential for therapeutic success. Expert Opinion on Therapeutic Targets, 25(11), 949-963. https://doi.org/10.1080/14728222.2021.2008907

Introduction: Clostridioides difficile infection (CDI) remains a worldwide clinical problem. Increased incidence of primary infection, occurrence of hypertoxigenic ribotypes, and more frequent occurrence of drug resistant, recurrent, and non-hospital... Read More about Clostridioides difficile: innovations in target discovery and potential for therapeutic success.

Impact of COVID-19 pandemic on prevalence of Clostridioides difficile infection in a UK tertiary centre (2021)
Journal Article
Voona, S., Abdic, H., Montgomery, R., Clarkson, A., Twitchell, H., Hills, T., …Monaghan, T. M. (2022). Impact of COVID-19 pandemic on prevalence of Clostridioides difficile infection in a UK tertiary centre. Anaerobe, 73, Article 102479. https://doi.org/10.1016/j.anaerobe.2021.102479

Serious concerns have been raised about a possible increase in cases of Clostridioides difficile infection (CDI) during the COVID-19 pandemic. We conducted a retrospective observational single centre study which revealed that total combined community... Read More about Impact of COVID-19 pandemic on prevalence of Clostridioides difficile infection in a UK tertiary centre.

A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection (2021)
Journal Article
Monaghan, T. M., Duggal, N. A., Rosati, E., Griffin, R., Hughes, J., Roach, B., …Kao, D. H. (2021). A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection. Cells, 10(11), Article 3234. https://doi.org/10.3390/cells10113234

Fecal microbiota transplantation (FMT) is highly effective in recurrent Clostridioides difficile infection (CDI); increasing evidence supports FMT in severe or fulminant Clostridioides difficile infection (SFCDI). However, the multifactorial mechanis... Read More about A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection.

Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle (2021)
Journal Article
Chidambaram, S. B., Essa, M. M., Rathipriya, A., Bishir, M., Ray, B., Mahalakshmi, A. M., …Monaghan, T. M. (2022). Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle. Pharmacology and Therapeutics, 231, Article 107988. https://doi.org/10.1016/j.pharmthera.2021.107988

The human microbiota comprises trillions of symbiotic microorganisms and is involved in regulating gastrointestinal (GI), immune, nervous system and metabolic homeostasis. Recent observations suggest a bidirectional communication between the gut micr... Read More about Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle.

Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India (2021)
Journal Article
Monaghan, T. M., Biswas, R. N., Nashine, R. R., Joshi, S. S., Mullish, B. H., Seekatz, A. M., …Kashyap, R. S. (2021). Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India. Microorganisms, 9(7), Article 1485. https://doi.org/10.3390/microorganisms9071485

Background: Non-communicable diseases (NCDs) have become a major cause of morbidity and mortality in India. Perturbation of host–microbiome interactions may be a key mechanism by which lifestyle-related risk factors such as tobacco use, alcohol consu... Read More about Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India.