Novel function for the p38-MK2 signaling pathway in circulating CD1c+ (BDCA-1+) myeloid dendritic cells from healthy donors and advanced cancer patients; inhibition of p38 enhances IL-12 whilst suppressing IL-10

Franks, Hester A.; Wang, Qunwei; Lax, Stephanie J.; Colllins, Mary K.; Escors, David; Patel, Poulam M.; Jackson, Andrew M.

doi:10.1002/ijc.28398

All Outputs (9)

Atopic eczema in primary care: evidence update and implications for practice (2023)
Journal Article
Santer, M., Ridd, M. J., Harvey, J., Lax, S., Muller, I., Roberts, A., & Thomas, K. S. (2024). Atopic eczema in primary care: evidence update and implications for practice. British Journal of General Practice, 74(738), 40-42. https://doi.org/10.3399/bjgp24X736101

Most people with eczema have mild or moderate disease, and most are treated in primary care.1 This article aims to support health professionals in helping patients get control of eczema in time-limited consultations. Recent updated National Institute... Read More about Atopic eczema in primary care: evidence update and implications for practice.

The long-term safety of topical corticosteroids in atopic dermatitis: A systematic review (2023)
Journal Article
Harvey, J., Lax, S. J., Lowe, A., Santer, M., Lawton, S., Langan, S. M., …Thomas, K. S. (2023). The long-term safety of topical corticosteroids in atopic dermatitis: A systematic review. Skin Health and Disease, 3(5), Article e268. https://doi.org/10.1002/ski2.268

Background: Topical corticosteroids (TCS) are a first-line treatment for eczema, but there are concerns about their safety when used long-term. Objectives: To systematically review adverse effects associated with longer-term use of TCS for eczema. Me... Read More about The long-term safety of topical corticosteroids in atopic dermatitis: A systematic review.

Public views are needed for skin colour scales (2023)
Journal Article
Lax, S. J., Roberts, A., Cliffe, E., Ramesh, G., Ayodele, D., Williams, H. C., …Leighton, P. (2023). Public views are needed for skin colour scales. British Journal of Dermatology, 189(5), 623-624. https://doi.org/10.1093/bjd/ljad189

Can co-created knowledge mobilisation interventions alter and enhance mindlines to improve childhood eczema care? A UK-based Social Impact Framework evaluation (2023)
Journal Article
Cowdell, F., Lax, S., Van Onselen, J., & Pendleton, R. (2023). Can co-created knowledge mobilisation interventions alter and enhance mindlines to improve childhood eczema care? A UK-based Social Impact Framework evaluation. BMJ Open, 13(4), Article e065557. https://doi.org/10.1136/bmjopen-2022-065557

Objective To evaluate the impact of using knowledge mobilisation interventions to alter and enhance mindlines and improve childhood eczema care. Design The eczema mindlines study involved three stages: (1) mapping and confirming eczema mindlines,... Read More about Can co-created knowledge mobilisation interventions alter and enhance mindlines to improve childhood eczema care? A UK-based Social Impact Framework evaluation.

Agreement and Correlation Between Different Topical Corticosteroid Potency Classification Systems (2022)
Journal Article
Bowie, A. C., Tadrous, M., Egeberg, A., Harvey, J., Lax, S. J., Thyssen, J. P., & Drucker, A. M. (2022). Agreement and Correlation Between Different Topical Corticosteroid Potency Classification Systems. JAMA Dermatology, E1-E5. https://doi.org/10.1001/jamadermatol.2022.1706

Importance: Topical corticosteroids (TCSs) are available in multiple potencies that alter their effectiveness and safety. Pharmacoepidemiologic studies on TCSs are hampered by the absence of a universal potency classification system, limiting compari... Read More about Agreement and Correlation Between Different Topical Corticosteroid Potency Classification Systems.

Strategies for using topical corticosteroids in children and adults with eczema (2022)
Journal Article
Lax, S., Harvey, J., Axon, E., Howells, L., Santer, M., Ridd, M., …Chalmers, J. (2022). Strategies for using topical corticosteroids in children and adults with eczema. Cochrane Database of Systematic Reviews, 3(3), Article CD013356

Background Eczema is a common skin condition. Although topical corticosteroids (TCS) have been a first-line treatment for eczema for decades, there are uncertainties over their optimal use. Objectives To establish the effectiveness and safety of diff... Read More about Strategies for using topical corticosteroids in children and adults with eczema.

Can atopic eczema and psoriasis coexist? A systematic review and meta?analysis (2021)
Journal Article
Cunliffe, A., Gran, S., Ali, U., Grindlay, D., Lax, S., Williams, H., & Burden-Teh, E. (2021). Can atopic eczema and psoriasis coexist? A systematic review and meta?analysis. Skin Health and Disease, 1(2), Article e29. https://doi.org/10.1002/ski2.29

Importance: Previous studies report both co-existence and mutual exclusivity of atopic eczema (AE) and psoriasis, but these have not been appraised systematically. Knowledge of such disease association throws light on disease mechanisms and may influ... Read More about Can atopic eczema and psoriasis coexist? A systematic review and meta?analysis.

The effect of iron deficiency and anaemia on women's health (2021)
Journal Article
Benson, C., Shah, A., Stanworth, S., Frise, C., Spiby, H., Lax, S., …Klein, A. (2021). The effect of iron deficiency and anaemia on women's health. Anaesthesia, 76(S4), 84-95. https://doi.org/10.1111/anae.15405

Iron deficiency and anaemia are global health problems and major causes of morbidity in women. Current definitions of anaemia in women are historic and have been challenged by recent data from observational studies. Menstrual loss, abnormal uterine b... Read More about The effect of iron deficiency and anaemia on women's health.

Novel function for the p38-MK2 signaling pathway in circulating CD1c+ (BDCA-1+) myeloid dendritic cells from healthy donors and advanced cancer patients; inhibition of p38 enhances IL-12 whilst suppressing IL-10 (2013)
Journal Article
Franks, H. A., Wang, Q., Lax, S. J., Colllins, M. K., Escors, D., Patel, P. M., & Jackson, A. M. (2014). Novel function for the p38-MK2 signaling pathway in circulating CD1c+ (BDCA-1+) myeloid dendritic cells from healthy donors and advanced cancer patients; inhibition of p38 enhances IL-12 whilst suppressing IL-10. International Journal of Cancer, 134(3), 575-586. https://doi.org/10.1002/ijc.28398

There is growing interest in myeloid (my) dendritic cells (DC) as an alternative to monocyte-derived DC (moDC) for immunotherapy. However, in contrast to moDC, little is known regarding the effect of malignancy on the function, abundance or use of in... Read More about Novel function for the p38-MK2 signaling pathway in circulating CD1c+ (BDCA-1+) myeloid dendritic cells from healthy donors and advanced cancer patients; inhibition of p38 enhances IL-12 whilst suppressing IL-10.