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Sustainable citric acid production from CO2 in an engineered cyanobacterium (2022)
Journal Article
Zhang, L., Bryan, S. J., & Selão, T. T. (2022). Sustainable citric acid production from CO2 in an engineered cyanobacterium. Frontiers in Microbiology, 13, Article 973244. https://doi.org/10.3389/fmicb.2022.973244

Citric acid is one of the most widely used organic acids in the world, with applications ranging from acidity regulation in food and beverages to metal chelation in hydrometallurgical processes. Most of its production is currently derived from fermen... Read More about Sustainable citric acid production from CO2 in an engineered cyanobacterium.

Evidence for Electron Transfer from the Bidirectional Hydrogenase to the Photosynthetic Complex I (NDH-1) in the Cyanobacterium Synechocystis sp. PCC 6803 (2022)
Journal Article
Appel, J., Craig, S., Theune, M., Hüren, V., Künzel, S., Forberich, B., …Gutekunst, K. (2022). Evidence for Electron Transfer from the Bidirectional Hydrogenase to the Photosynthetic Complex I (NDH-1) in the Cyanobacterium Synechocystis sp. PCC 6803. Microorganisms, 10(8), Article 1617. https://doi.org/10.3390/microorganisms10081617

The cyanobacterial bidirectional [NiFe]-hydrogenase is a pentameric enzyme. Apart from the small and large hydrogenase subunits (HoxYH) it contains a diaphorase module (HoxEFU) that interacts with NAD(P)+ and ferredoxin. HoxEFU shows strong similarit... Read More about Evidence for Electron Transfer from the Bidirectional Hydrogenase to the Photosynthetic Complex I (NDH-1) in the Cyanobacterium Synechocystis sp. PCC 6803.

Removal of Nutrients and Pesticides from Agricultural Runoff Using Microalgae and Cyanobacteria (2022)
Journal Article
Castellanos-Estupiñan, M. A., Carrillo-Botello, A. M., Rozo-Granados, L. S., Becerra-Moreno, D., García-Martínez, J. B., Urbina-Suarez, N. A., …Zuorro, A. (2022). Removal of Nutrients and Pesticides from Agricultural Runoff Using Microalgae and Cyanobacteria. Water, 14(4), Article 558. https://doi.org/10.3390/w14040558

The use of pesticides in agriculture has ensured the production of different crops. However, pesticides have become an emerging public health problem for Latin American countries due to their excessive use, inadequate application, toxic characteristi... Read More about Removal of Nutrients and Pesticides from Agricultural Runoff Using Microalgae and Cyanobacteria.

Engineering improved ethylene production: Leveraging systems Biology and adaptive laboratory evolution (2021)
Journal Article
Vaud, S., Pearcy, N., Hanževački, M., Van Hagen, A. M., Abdelrazig, S., Safo, L., …Bryan, S. J. (2021). Engineering improved ethylene production: Leveraging systems Biology and adaptive laboratory evolution. Metabolic Engineering, 67, 308-320. https://doi.org/10.1016/j.ymben.2021.07.001

Ethylene is a small hydrocarbon gas widely used in the chemical industry. Annual worldwide production currently exceeds 150 million tons, producing considerable amounts of CO2 contributing to climate change. The need for a sustainable alternative is... Read More about Engineering improved ethylene production: Leveraging systems Biology and adaptive laboratory evolution.

Nanorg Microbial Factories: Light-Driven Renewable Biochemical Synthesis Using Quantum Dot-Bacteria Nanobiohybrids (2019)
Journal Article
Ding, Y., Bertram, J. R., Eckert, C., Bommareddy, R. R., Patel, R., Conradie, A., …Nagpal, P. (2019). Nanorg Microbial Factories: Light-Driven Renewable Biochemical Synthesis Using Quantum Dot-Bacteria Nanobiohybrids. Journal of the American Chemical Society, 141(26), 10272-10282. https://doi.org/10.1021/jacs.9b02549

Living cells do not interface naturally with nanoscale materials, although such artificial organisms can have unprecedented multifunctional properties, like wireless activation of enzyme function using electromagnetic stimuli. Realizing such interfac... Read More about Nanorg Microbial Factories: Light-Driven Renewable Biochemical Synthesis Using Quantum Dot-Bacteria Nanobiohybrids.

Uptake and transport of B12-conjugated nanoparticles in airway epithelium (2013)
Journal Article
Fowler, R., Vllasaliu, D., Falcone, F. H., Garnett, M., Smith, B., Horsley, H., …Stolnik, S. (2013). Uptake and transport of B12-conjugated nanoparticles in airway epithelium. Journal of Controlled Release, 172(1), https://doi.org/10.1016/j.jconrel.2013.08.028

Non-invasive delivery of biotherapeutics, as an attractive alternative to injections, could potentially be achieved through the mucosal surfaces, utilizing nanoscale therapeutic carriers. However, nanoparticles do not readily cross the mucosal barrie... Read More about Uptake and transport of B12-conjugated nanoparticles in airway epithelium.

Nanoparticle transport in epithelial cells: pathway switching through bioconjugation (2013)
Journal Article
Fowler, R., Vllasaliu, D., Trillo, F. F., Garnett, M., Alexander, C., Horsley, H., …Stolnik, S. (in press). Nanoparticle transport in epithelial cells: pathway switching through bioconjugation. Small, 9(19), https://doi.org/10.1002/smll.201202623

The understanding and control of nanoparticle transport into and through cellular compartments is central to biomedical applications of nanotechnology. Here, it is shown that the transport pathway of 50 nm polystyrene nanoparticles decorated with vit... Read More about Nanoparticle transport in epithelial cells: pathway switching through bioconjugation.