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All Outputs (10)

Simultaneous Tracking of Pseudomonas aeruginosa motility in liquid and at the Solid-Liquid Interface Reveals Differential Roles for the Flagellar Stators (2019)
Journal Article
Hook, A. L., Flewellen, J. L., Dubern, J., Carabelli, A., Zald, I. M., Berry, R. M., …Alexander, M. R. (2019). Simultaneous Tracking of Pseudomonas aeruginosa motility in liquid and at the Solid-Liquid Interface Reveals Differential Roles for the Flagellar Stators. mSystems, 4(5), Article e00390-19. https://doi.org/10.1128/mSystems.00390-19

Bacteria sense chemicals, surfaces, and other cells and move toward some and away from others. Studying how single bacterial cells in a population move requires sophisticated tracking and imaging techniques. We have established quantitative methodolo... Read More about Simultaneous Tracking of Pseudomonas aeruginosa motility in liquid and at the Solid-Liquid Interface Reveals Differential Roles for the Flagellar Stators.

Surface plasmon resonance imaging of excitable cells (2019)
Journal Article
Howe, C. L., Webb, K. F., Abayzeed, S. A., Anderson, D. J., Denning, C., & Russell, N. A. (2019). Surface plasmon resonance imaging of excitable cells. Journal of Physics D: Applied Physics, 52(10), Article 104001. https://doi.org/10.1088/1361-6463/aaf849

Surface plasmons (SPs) are surface charge density oscillations occuring at a metal/dieletric interface and are highly sensitive to refractive index variations adjacent to the surface. This sensitivity has been exploited successfully for chemical and... Read More about Surface plasmon resonance imaging of excitable cells.

A Bayesian approach to modelling heterogeneous calcium responses in cell populations (2017)
Journal Article
Tilunaite, A., Croft, W., Russell, N. A., Bellamy, T. C., & Thul, R. (2017). A Bayesian approach to modelling heterogeneous calcium responses in cell populations. PLoS Computational Biology, 13(10), Article e1005794. https://doi.org/10.1371/journal.pcbi.1005794

Calcium responses have been observed as spikes of the whole-cell calcium concentration in numerous cell types and are essential for translating extracellular stimuli into cellular responses. While there are several suggestions for how this encoding i... Read More about A Bayesian approach to modelling heterogeneous calcium responses in cell populations.

One-pot RAFT and fast polymersomes assembly: a ‘beeline’ from monomers to drug-loaded nanovectors (2016)
Journal Article
Mastrotto, F., Breen, A. F., Sicilia, G., Murdan, S., Johnstone, A. D., Marsh, G. E., …Mantovani, G. (2016). One-pot RAFT and fast polymersomes assembly: a ‘beeline’ from monomers to drug-loaded nanovectors. Polymer Chemistry, 7(44), 6714-6724. https://doi.org/10.1039/C6PY01292B

Rapid and simple routes to functional polymersomes are increasingly needed to expand their clinical or industrial applications. Here we describe a novel strategy where polymersomes are prepared through an in-line process in just a few hours, starting... Read More about One-pot RAFT and fast polymersomes assembly: a ‘beeline’ from monomers to drug-loaded nanovectors.

Probabilistic encoding of stimulus strength in astrocyte global calcium signals (2015)
Journal Article
Croft, W., Reusch, K., Tilunaite, A., Russell, N. A., Thul, R., & Bellamy, T. C. (2016). Probabilistic encoding of stimulus strength in astrocyte global calcium signals. Glia, 64(4), 537-552. https://doi.org/10.1002/glia.22947

© 2016 Wiley Periodicals, Inc. Astrocyte calcium signals can range in size from subcellular microdomains to waves that spread through the whole cell (and into connected cells). The differential roles of such local or global calcium signaling are unde... Read More about Probabilistic encoding of stimulus strength in astrocyte global calcium signals.

Multivariate analysis of 3D ToF-SIMS images: method validation and application to cultured neuronal networks (2015)
Journal Article
Van Nuffel, S., Parmenter, C. D., Scurr, D. J., Russell, N. A., & Zelzer, M. (in press). Multivariate analysis of 3D ToF-SIMS images: method validation and application to cultured neuronal networks. Analyst, 141(1), https://doi.org/10.1039/c5an01743b

Advanced data analysis tools are crucial for the application of ToF-SIMS analysis to biological samples. Here, we demonstrate that by using a training set approach principal components analysis (PCA) can be performed on large 3D ToF-SIMS images of ne... Read More about Multivariate analysis of 3D ToF-SIMS images: method validation and application to cultured neuronal networks.

Responsive cell–material interfaces (2015)
Journal Article
Dhowre, H. S., Rajput, S., Russell, N. A., & Zelzer, M. (2015). Responsive cell–material interfaces. Nanomedicine, 10(5), https://doi.org/10.2217/nnm.14.225

Major design aspects for novel biomaterials are driven by the desire to mimic more varied and complex properties of a natural cellular environment with man-made materials. The development of stimulus responsive materials makes considerable contributi... Read More about Responsive cell–material interfaces.

Photochromic molecular implementations of universal computation (2014)
Journal Article
Chaplin, J. C., Krasnogor, N., & Russell, N. A. (2014). Photochromic molecular implementations of universal computation. BioSystems, 126, 12-26. https://doi.org/10.1016/j.biosystems.2014.09.004

Unconventional computing is an area of research in which novel materials and paradigms are utilised to implement computation. Previously we have demonstrated how registers, logic gates and logic circuits can be implemented, unconventionally, with a b... Read More about Photochromic molecular implementations of universal computation.

Stimulus Discrimination in Cerebellar Purkinje Neurons (2014)
Journal Article
Reusch, K., Russell, N. A., & Bellamy, T. C. (2014). Stimulus Discrimination in Cerebellar Purkinje Neurons. PLoS ONE, 9(2), https://doi.org/10.1371/journal.pone.0087828

Cerebellar Purkinje neurons fire spontaneously in the absence of synaptic input. Overlaid on this intrinsic activity, excitatory input from parallel fibres can add simple spikes to the output train, whereas inhibitory input from interneurons can intr... Read More about Stimulus Discrimination in Cerebellar Purkinje Neurons.

A reconfigurable real-time compressive-sampling camera for biological applications (2011)
Journal Article
Fu, B., Pitter, M. C., & Russell, N. A. (2011). A reconfigurable real-time compressive-sampling camera for biological applications. PLoS ONE, 6(10), Article e26306. https://doi.org/10.1371/journal.pone.0026306

Many applications in biology, such as long-term functional imaging of neural and cardiac systems, require continuous high-speed imaging. This is typically not possible, however, using commercially available systems. The frame rate and the recording t... Read More about A reconfigurable real-time compressive-sampling camera for biological applications.