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GSK3β-SCFFBXW7α mediated phosphorylation and ubiquitination of IRF1 are required for its transcription-dependent turnover (2019)
Journal Article
Garvin, A. J., Khalaf, A. H., Rettino, A., Xicluna, J., Butler, L., Morris, J. R., …Clarke, N. M. (2019). GSK3β-SCFFBXW7α mediated phosphorylation and ubiquitination of IRF1 are required for its transcription-dependent turnover. Nucleic Acids Research, 47(9), 4476-4494. https://doi.org/10.1093/nar/gkz163

IRF1 (Interferon Regulatory Factor-1) is the prototype of the IRF family of DNA binding transcription factors. IRF1 protein expression is regulated by transient up-regulation in response to external stimuli followed by rapid degradation via the ubiqu... Read More about GSK3β-SCFFBXW7α mediated phosphorylation and ubiquitination of IRF1 are required for its transcription-dependent turnover.