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All Outputs (10)

Tracking subjects' strategies in behavioural choice experiments at trial resolution. (2024)
Journal Article
Maggi, S., Hock, R. M., O'Neill, M., Buckley, M. J., Moran, P. M., Bast, T., …Humphries, M. D. (2024). Tracking subjects' strategies in behavioural choice experiments at trial resolution. eLife, 13, Article e86491. https://doi.org/10.7554/eLife.86491

Investigating how, when, and what subjects learn during decision-making tasks requires tracking their choice strategies on a trial-by-trial basis. Here we present a simple but effective probabilistic approach to tracking choice strategies at trial re... Read More about Tracking subjects' strategies in behavioural choice experiments at trial resolution..

Predictive coding of the statistical parameters of uncertain rewards by orbitofrontal neurons (2018)
Journal Article
O’Neill, M., & Schultz, W. (2018). Predictive coding of the statistical parameters of uncertain rewards by orbitofrontal neurons. Behavioural Brain Research, 355, 90-94. https://doi.org/10.1016/j.bbr.2018.04.041

Uncertain reward outcomes are characterised by statistical parameters that capture the numerical values of the underlying probability distributions of reward values, including the expected value, risk (variance) and probability. Here we show coding o... Read More about Predictive coding of the statistical parameters of uncertain rewards by orbitofrontal neurons.

Economic risk coding by single neurons in the orbitofrontal cortex (2014)
Journal Article
O’Neill, M., & Schultz, W. (2015). Economic risk coding by single neurons in the orbitofrontal cortex. Journal of Physiology - Paris, 109(1-3), 70-77. https://doi.org/10.1016/j.jphysparis.2014.06.002

Risk is a ubiquitous feature of the environment for all organisms. Very few things in life are achieved with absolute certainty. Therefore, it is essential that organisms process risky information efficiently to promote adaptive behaviour and enhance... Read More about Economic risk coding by single neurons in the orbitofrontal cortex.

Risk Prediction Error Coding in Orbitofrontal Neurons (2013)
Journal Article
O'Neill, M., & Schultz, W. (2013). Risk Prediction Error Coding in Orbitofrontal Neurons. Journal of Neuroscience, 33(40), 15810-15814. https://doi.org/10.1523/jneurosci.4236-12.2013

Risk is a ubiquitous feature of life. It plays an important role in economic decisions by affecting subjective reward value. Informed decisions require accurate risk information for each choice option. However, risk is often not constant but changes... Read More about Risk Prediction Error Coding in Orbitofrontal Neurons.

Neuronal signals for reward risk in frontal cortex: Risky reward signals (2011)
Journal Article
O’Neill, M., Tobler, P. N., Kobayashi, S., & Schultz, W. (2011). Neuronal signals for reward risk in frontal cortex: Risky reward signals. Annals of the New York Academy of Sciences, 1239(1), 109-117. https://doi.org/10.1111/j.1749-6632.2011.06256.x

Rewards can be viewed as probability distributions of reward values. Besides expected (mean) value, a key parameter of such distributions is variance (or standard deviation), which constitutes a measure of risk. Single neurons in orbitofrontal cortex... Read More about Neuronal signals for reward risk in frontal cortex: Risky reward signals.

Coding of Reward Risk by Orbitofrontal Neurons Is Mostly Distinct from Coding of Reward Value (2010)
Journal Article
O'Neill, M., & Schultz, W. (2010). Coding of Reward Risk by Orbitofrontal Neurons Is Mostly Distinct from Coding of Reward Value. Neuron, 68(4), 789-800. https://doi.org/10.1016/j.neuron.2010.09.031

Risky decision-making is altered in humans and animals with damage to the orbitofrontal cortex. However, the cellular function of the intact orbitofrontal cortex in processing information relevant for risky decisions is unknown. We recorded responses... Read More about Coding of Reward Risk by Orbitofrontal Neurons Is Mostly Distinct from Coding of Reward Value.

Risky Business: Disambiguating Ambiguity-Related Responses in the Brain (2009)
Journal Article
Kobayashi, S., & O'Neill, M. (2009). Risky Business: Disambiguating Ambiguity-Related Responses in the Brain. Journal of Neurophysiology, 102(2), 645-647. https://doi.org/10.1152/jn.00406.2009

Previous functional MRI studies reported neural correlates of risk and ambiguity based on behavioral economic theories. A recent study controlled for uncertainty by adding noise to information of an impending aversive event and demonstrated brain are... Read More about Risky Business: Disambiguating Ambiguity-Related Responses in the Brain.

Amphetamine and the adenosine A2A antagonist KW-6002 enhance the effects of conditional temporal probability of a stimulus in rats (2007)
Journal Article
O'Neill, M., & Brown, V. J. (2007). Amphetamine and the adenosine A2A antagonist KW-6002 enhance the effects of conditional temporal probability of a stimulus in rats. Behavioral Neuroscience, 121(3), 535-542. https://doi.org/10.1037/0735-7044.121.3.535

As the length of foreperiod preceding an imperative signal increases, reaction time decreases and anticipatory (prior to the signal) responding increases. The authors designed a task to dissociate the effect of elapsing time in the foreperiod and con... Read More about Amphetamine and the adenosine A2A antagonist KW-6002 enhance the effects of conditional temporal probability of a stimulus in rats.

The effect of striatal dopamine depletion and the adenosine A2A antagonist KW-6002 on reversal learning in rats (2007)
Journal Article
O’Neill, M., & Brown, V. J. (2007). The effect of striatal dopamine depletion and the adenosine A2A antagonist KW-6002 on reversal learning in rats. Neurobiology of Learning and Memory, 88(1), 75-81. https://doi.org/10.1016/j.nlm.2007.03.003

This study assessed whether dopamine in the dorsomedial striatum is necessary for flexible adaptation to changes in stimulus–response contingencies. As KW-6002 (Istradefylline), an adenosine A2A antagonist, improves motor deficits resulting from stri... Read More about The effect of striatal dopamine depletion and the adenosine A2A antagonist KW-6002 on reversal learning in rats.

The effect of the adenosine A2A antagonist KW-6002 on motor and motivational processes in the rat (2005)
Journal Article
O’Neill, M., & Brown, V. J. (2006). The effect of the adenosine A2A antagonist KW-6002 on motor and motivational processes in the rat. Psychopharmacology, 184(1), 46-55. https://doi.org/10.1007/s00213-005-0240-z

Rationale It is well established that humans and rats respond to an imperative stimulus more rapidly as a function of the foreperiod preceding the target, and with this decrease in mean response time, there is also an increase in anticipatory (pri... Read More about The effect of the adenosine A2A antagonist KW-6002 on motor and motivational processes in the rat.