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All Outputs (134)

Cost-effectiveness of two online interventions supporting self-care for eczema for parents/carers and young people (2024)
Journal Article
Sach, T. H., Onoja, M., Clarke, H., Santer, M., Muller, I., Becque, T., …Thomas, K. S. (2024). Cost-effectiveness of two online interventions supporting self-care for eczema for parents/carers and young people. European Journal of Health Economics, https://doi.org/10.1007/s10198-023-01649-9

Objective: To estimate the cost-effectiveness of online behavioral interventions (EczemaCareOnline.org.uk) designed to support eczema self-care management for parents/carers and young people from an NHS perspective. Methods: Two within-trial economic... Read More about Cost-effectiveness of two online interventions supporting self-care for eczema for parents/carers and young people.

How can community pharmacists be supported to manage skin conditions? A multistage stakeholder research prioritisation exercise (2024)
Journal Article
Harvey, J., Shariff, Z., Anderson, C., Boyd, M. J., Ridd, M. J., Santer, M., …Leighton, P. (2024). How can community pharmacists be supported to manage skin conditions? A multistage stakeholder research prioritisation exercise. BMJ Open, 14(1), Article e071863. https://doi.org/10.1136/bmjopen-2023-071863

Objective: To establish research priorities which will support the development and delivery of community pharmacy initiatives for the management of skin conditions. Design: An iterative, multistage stakeholder consultation consisting of online survey... Read More about How can community pharmacists be supported to manage skin conditions? A multistage stakeholder research prioritisation exercise.

Atopic eczema in primary care: evidence update and implications for practice (2023)
Journal Article
Santer, M., Ridd, M. J., Harvey, J., Lax, S., Muller, I., Roberts, A., & Thomas, K. S. (2024). Atopic eczema in primary care: evidence update and implications for practice. British Journal of General Practice, 74(738), 40-42. https://doi.org/10.3399/bjgp24X736101

Most people with eczema have mild or moderate disease, and most are treated in primary care.1 This article aims to support health professionals in helping patients get control of eczema in time-limited consultations. Recent updated National Institute... Read More about Atopic eczema in primary care: evidence update and implications for practice.

How to use the Harmonising Outcome Measures for Eczema Core Outcome Set for atopic dermatitis trials: a users’ guide (2023)
Journal Article
Thomas, K. S., Howells, L., Leshem, Y. A., Simpson, E. L., Apfelbacher, C., Spuls, P. I., …Stuart, B. L. (in press). How to use the Harmonising Outcome Measures for Eczema Core Outcome Set for atopic dermatitis trials: a users’ guide. British Journal of Dermatology, https://doi.org/10.1093/bjd/ljad497

Background The Harmonising Outcome Measures for Eczema (HOME) initiative has agreed upon the Core Outcome Set (COS) for use in atopic dermatitis (AD) clinical trials, but additional guidance is needed to maximize its uptake. Objectives To provid... Read More about How to use the Harmonising Outcome Measures for Eczema Core Outcome Set for atopic dermatitis trials: a users’ guide.

Cost-effectiveness of Spironolactone for Adult Female Acne (SAFA): economic evaluation alongside a randomised controlled trial (2023)
Journal Article
Pyne, S., Sach, T. H., Lawrence, M., Renz, S., Eminton, Z., Stuart, B., …Santer, M. (2023). Cost-effectiveness of Spironolactone for Adult Female Acne (SAFA): economic evaluation alongside a randomised controlled trial. BMJ Open, 13(12), Article e073245. https://doi.org/10.1136/bmjopen-2023-073245

Objective This study aims to estimate the cost-effectiveness of oral spironolactone plus routine topical treatment compared with routine topical treatment alone for persistent acne in adult women from a British NHS perspective over 24 weeks. Design E... Read More about Cost-effectiveness of Spironolactone for Adult Female Acne (SAFA): economic evaluation alongside a randomised controlled trial.

Treatment of Hidradenitis Suppurativa Evaluation Study: the THESEUS prospective cohort study (2023)
Journal Article
Ingram, J. R., Bates, J., Cannings-John, R., Collier, F., Gibbons, A., Harris, C., …Thomas-Jones, E. (2023). Treatment of Hidradenitis Suppurativa Evaluation Study: the THESEUS prospective cohort study. Health Technology Assessment, 27(30), https://doi.org/10.3310/HWNM2189

Background Hidradenitis suppurativa is a chronic inflammatory skin disease characterised by recurrent inflammatory lesions and skin tunnels in flexural sites such as the axilla. Deroofing of skin tunnels and laser treatment are standard hidradenit... Read More about Treatment of Hidradenitis Suppurativa Evaluation Study: the THESEUS prospective cohort study.

Eczema Bathing Study – how often should we bathe? (2023)
Dataset
Harrison, E., & Thomas, K. (2023). Eczema Bathing Study – how often should we bathe?. [Dataset]. https://doi.org/10.1186/isrctn12016473

Background and study aims The Eczema Bathing Study is part of the Rapid Eczema Trials project. The researchers hope to answer many questions about how to manage eczema through this project. People with eczema are helping to prioritise, design and ru... Read More about Eczema Bathing Study – how often should we bathe?.

A core domain set for pyoderma gangrenosum trial outcomes - an international e-Delphi and consensus study from the UPGRADE initiative (2023)
Journal Article
Jacobson, M. E., Rick, J. W., Gerbens, L. A., Baghoomian, W., Gould, L. J., Marzano, A. V., …UPGRADE. (2024). A core domain set for pyoderma gangrenosum trial outcomes - an international e-Delphi and consensus study from the UPGRADE initiative. British Journal of Dermatology, 190(3), 392-401. https://doi.org/10.1093/bjd/ljad420

Importance Pyoderma gangrenosum (PG) is a rare ulcerative skin condition with no current standardized outcomes or outcome measures. With a rich investigational therapeutic pipeline, standardization of outcomes and improvement of data quality and i... Read More about A core domain set for pyoderma gangrenosum trial outcomes - an international e-Delphi and consensus study from the UPGRADE initiative.

Comparison of lotions, creams, gels and ointments for the treatment of childhood eczema: the BEE RCT (2023)
Journal Article
Ridd, M. J., Wells, S., MacNeill, S. J., Sanderson, E., Webb, D., Banks, J., …Santer, M. (2023). Comparison of lotions, creams, gels and ointments for the treatment of childhood eczema: the BEE RCT. Health Technology Assessment, 27(19), 1-120. https://doi.org/10.3310/gzqw6681

Background: Emollients are recommended for children with eczema (atopic eczema/dermatitis). A lack of head-to-head comparisons of the effectiveness and acceptability of the different types of emollients has resulted in a 'trial and error' approach to... Read More about Comparison of lotions, creams, gels and ointments for the treatment of childhood eczema: the BEE RCT.

Treatment of Hidradenitis Suppurativa Evaluation Study (THESEUS): a prospective cohort study (2023)
Journal Article
Ingram, J., Thomas, K., Cannings, R., Evans, J., Gibbons, A., Howes, R., …Leighton, P. (2024). Treatment of Hidradenitis Suppurativa Evaluation Study (THESEUS): a prospective cohort study. British Journal of Dermatology, 190(3), 382-391. https://doi.org/10.1093/bjd/ljad388

Background Hidradenitis suppurativa (HS) is a chronic, painful disease affecting flexures and other skin regions, producing nodules, abscesses and skin tunnels. Laser treatment targeting hair follicles and deroofing of skin tunnels are standard HS... Read More about Treatment of Hidradenitis Suppurativa Evaluation Study (THESEUS): a prospective cohort study.

The long-term safety of topical corticosteroids in atopic dermatitis: A systematic review (2023)
Journal Article
Harvey, J., Lax, S. J., Lowe, A., Santer, M., Lawton, S., Langan, S. M., …Thomas, K. S. (2023). The long-term safety of topical corticosteroids in atopic dermatitis: A systematic review. Skin Health and Disease, 3(5), Article e268. https://doi.org/10.1002/ski2.268

Background: Topical corticosteroids (TCS) are a first-line treatment for eczema, but there are concerns about their safety when used long-term. Objectives: To systematically review adverse effects associated with longer-term use of TCS for eczema. Me... Read More about The long-term safety of topical corticosteroids in atopic dermatitis: A systematic review.

Emollients for preventing atopic eczema: Cost‐effectiveness analysis of the BEEP trial (2023)
Journal Article
Sach, T. H., Lartey, S. T., Davies, C., Chalmers, J. R., Haines, R. H., Bradshaw, L. E., …Williams, H. C. (2023). Emollients for preventing atopic eczema: Cost‐effectiveness analysis of the BEEP trial. Clinical & Experimental Allergy, 53(10), 1011-1019. https://doi.org/10.1111/cea.14381

Background Recent discoveries have led to the suggestion that enhancing skin barrier from birth might prevent eczema and food allergy. Objective To determine the cost‐effectiveness of daily all‐over‐body application of emollient during the firs... Read More about Emollients for preventing atopic eczema: Cost‐effectiveness analysis of the BEEP trial.

The Harmonising Outcome Measures for Eczema (HOME) implementation roadmap (2023)
Journal Article
Leshem, Y. A., Simpson, E., Apfelbacher, C., Spuls, P., Thomas, K. S., Schmitt, J., …Williams, H. C. (2023). The Harmonising Outcome Measures for Eczema (HOME) implementation roadmap. British Journal of Dermatology, 189(6), 710-718. https://doi.org/10.1093/bjd/ljad278

Background Core outcome sets (COS) are consensus-driven sets of minimum outcomes that should be measured and reported in all clinical trials. COS aim to reduce heterogeneity in outcome measurement and reporting, and selective outcome reporting. Imple... Read More about The Harmonising Outcome Measures for Eczema (HOME) implementation roadmap.

Reporting of Harmonising Outcome Measures for Eczema (HOME) core outcome set instruments in randomized clinical trials for systemic treatments in atopic dermatitis (2023)
Journal Article
Lam, M., Spuls, P. I., Leshem, Y. A., Gerbens, L. A. A., Thomas, K. S., Arents, B., …Drucker, A. M. (2023). Reporting of Harmonising Outcome Measures for Eczema (HOME) core outcome set instruments in randomized clinical trials for systemic treatments in atopic dermatitis. British Journal of Dermatology, 189(4), 494-496. https://doi.org/10.1093/bjd/ljad237

Implementation of the HOME core outcome set for clinical trials of atopic eczema—barriers and opportunities: the HOME IX meeting report (2023)
Journal Article
Jacobson, M. E., Thomas, K. S., Apfelbacher, C. J., Leshem, Y. A., Williams, H. C., Gerbens, L. A. A., …On behalf of the Harmonising Outcome Measures for Eczema (HOME) Initiative. (2023). Implementation of the HOME core outcome set for clinical trials of atopic eczema—barriers and opportunities: the HOME IX meeting report. Archives of Dermatological Research, 315, 2617-2622. https://doi.org/10.1007/s00403-023-02647-w

The Harmonising Outcome Measures for Eczema (HOME) initiative established a core outcome set (COS) for atopic eczema (AE) clinical trials in 2019. This set encompasses four core outcome domains and corresponding measurement instruments: clinical sign... Read More about Implementation of the HOME core outcome set for clinical trials of atopic eczema—barriers and opportunities: the HOME IX meeting report.

RF04 Oral spironolactone for adult female acne (SAFA): a multicentre, double-blind, randomized trial (2023)
Journal Article
Santer, M., Layton, A., Lau, E., Eminton, Z., Stuart, B., Sach, T., …Lawrence, M. (2023). RF04 Oral spironolactone for adult female acne (SAFA): a multicentre, double-blind, randomized trial. British Journal of Dermatology, 188(Supplement_4), Article ljad113.013. https://doi.org/10.1093/bjd/ljad113.013

Acne is common and results in significant burden and patients with acne frequently receive prolonged oral antibiotics leading to antimicrobial resistance. Oral spironolactone is prescribed for acne, although there is a paucity of evidence on its effe... Read More about RF04 Oral spironolactone for adult female acne (SAFA): a multicentre, double-blind, randomized trial.

Research priorities in the management of hidradenitis suppurativa (2023)
Journal Article
Leighton, P., Howells, L., Bates, J., Gibbons, A., Cannings-John, R., Collier, F., …Ingram, J. R. (2023). Research priorities in the management of hidradenitis suppurativa. British Journal of Dermatology, 189(3), 343–345. https://doi.org/10.1093/bjd/ljad152

There is a need for high-quality research to support the management of hidradenitis suppurativa. This letter offers suggestions for priority research topics derived from a stakeholder consensus meeting. Investigation of laser hair removal treatment,... Read More about Research priorities in the management of hidradenitis suppurativa.