Skip to main content

Research Repository

Advanced Search

All Outputs (110)

Ethnicity and socio-economic status affects the incidence and survival of hepatosplenic T-cell lymphoma (2024)
Journal Article
Bishton, M. J., Crooks, C. J., Card, T. R., & West, J. (2024). Ethnicity and socio-economic status affects the incidence and survival of hepatosplenic T-cell lymphoma. British Journal of Haematology, https://doi.org/10.1111/bjh.19371

To address the lack of contemporary population-based epidemiological studies of hepatosplenic T-cell lymphoma (HSTCL), we undertook a population-based study of ICD-O-3-coded HSTCL in England. We used the National Cancer Registration Dataset and linke... Read More about Ethnicity and socio-economic status affects the incidence and survival of hepatosplenic T-cell lymphoma.

Smoking is a risk factor for autoimmune hepatitis: An English registry-based case-control study (2024)
Journal Article
Grønbæk, L., Omeife, H., Ban, L., Crooks, C. J., Card, T. R., Jepsen, P., & West, J. (2024). Smoking is a risk factor for autoimmune hepatitis: An English registry-based case-control study. Clinical Epidemiology, 16, 23-30. https://doi.org/10.2147/CLEP.S439219

Purpose: Smoking is a risk factor for some autoimmune diseases, but its association with autoimmune hepatitis remains unknown. We conducted a population-based matched case–control study to examine the association between tobacco smoking and the risk... Read More about Smoking is a risk factor for autoimmune hepatitis: An English registry-based case-control study.

Risk of alcohol-related liver disease in the offspring of parents with alcohol-related liver disease: A nationwide cohort study (2023)
Journal Article
Jepsen, P., West, J., Kann, A. E., Kraglund, F., Morling, J., Crooks, C., & Askgaard, G. (2023). Risk of alcohol-related liver disease in the offspring of parents with alcohol-related liver disease: A nationwide cohort study. Hepatology, https://doi.org/10.1097/hep.0000000000000747

Background and aims: Offspring of patients with alcohol-related liver disease (ALD) may have higher risk of ALD. We examined their risk of ALD and survival with ALD. Approach & Results: We used Danish nationwide registries to identify offspring of... Read More about Risk of alcohol-related liver disease in the offspring of parents with alcohol-related liver disease: A nationwide cohort study.

Outcomes after emergency appendicectomy in patients with liver cirrhosis: a population-based cohort study from England (2023)
Journal Article
Adiamah, A., Rashid, A., Crooks, C. J., Hammond, J. S., Jepsen, P., West, J., & Humes, D. J. (2023). Outcomes after emergency appendicectomy in patients with liver cirrhosis: a population-based cohort study from England. Langenbeck's Archives of Surgery, 408, Article 362. https://doi.org/10.1007/s00423-023-03072-3

Introduction The mortality risk after appendicectomy in patients with liver cirrhosis is predicted to be higher than in the general population given the associated risk of perioperative bleeding, infections and liver decompensation. This population-... Read More about Outcomes after emergency appendicectomy in patients with liver cirrhosis: a population-based cohort study from England.

Cause-specific mortality in patients with alcohol-related liver disease in Denmark: a population-based study (2023)
Journal Article
Kann, A. E., Jepsen, P., Madsen, L. G., West, J., & Askgaard, G. (2023). Cause-specific mortality in patients with alcohol-related liver disease in Denmark: a population-based study. Lancet Gastroenterology and Hepatology, 8(11), 1028-1034. https://doi.org/10.1016/S2468-1253%2823%2900192-9

Background Knowledge of the causes of death is essential to prevent premature death in alcohol-related liver disease (ALD). We examined cause-specific mortality, including death due to specific cancers, in 15 years after diagnosis of ALD. Methods... Read More about Cause-specific mortality in patients with alcohol-related liver disease in Denmark: a population-based study.

Understanding colorectal cancer risk for symptomatic patients in primary care: A cohort study utilising faecal immunochemical tests and blood results in England (2023)
Journal Article
Crooks, C. J., Banerjea, A., Jones, J., Chapman, C., Oliver, S., West, J., & Humes, D. J. (2023). Understanding colorectal cancer risk for symptomatic patients in primary care: A cohort study utilising faecal immunochemical tests and blood results in England. Alimentary Pharmacology and Therapeutics, 58(4), 443-452. https://doi.org/10.1111/apt.17632

Background: A faecal immunochemical tests (FIT) cut-off of ≥10 μg Hb/g faeces is now recommended in the UK as a gateway to urgent (suspected cancer) investigation for colorectal cancer (CRC), based on an expected CRC risk threshold of 3%. Aims: To qu... Read More about Understanding colorectal cancer risk for symptomatic patients in primary care: A cohort study utilising faecal immunochemical tests and blood results in England.

Respiratory rate responses to both hypercapnia and acidaemia are modified by age in patients with acidosis (2023)
Journal Article
Crooks, C. J., West, J., Morling, J. R., Simmonds, M., Juurlink, I., Briggs, S., …Fogarty, A. W. (2023). Respiratory rate responses to both hypercapnia and acidaemia are modified by age in patients with acidosis. Respiratory Physiology and Neurobiology, 315, Article 104098. https://doi.org/10.1016/j.resp.2023.104098

Objective To explore the associations between arterial pO2, pCO2 and pH and how these are modified by age. Methods An analysis of 2598 patients admitted with a diagnosis of Covid-19 infection to a large UK teaching hospital. Results There we... Read More about Respiratory rate responses to both hypercapnia and acidaemia are modified by age in patients with acidosis.

1-year survival in haemophagocytic lymphohistiocytosis: a nationwide cohort study from England 2003–2018 (2023)
Journal Article
West, J., Stilwell, P., Liu, H., Ban, L., Bythell, M., Card, T., …Crooks, C. (2023). 1-year survival in haemophagocytic lymphohistiocytosis: a nationwide cohort study from England 2003–2018. Journal of Hematology and Oncology, 16, Article 56. https://doi.org/10.1186/s13045-023-01434-4

Haemophagocytic lymphohistiocytosis (HLH) is a lethal syndrome of excessive immune activation. We undertook a nationwide study in England of all cases of HLH diagnosed between 2003 and 2018, using linked electronic health data from hospital admission... Read More about 1-year survival in haemophagocytic lymphohistiocytosis: a nationwide cohort study from England 2003–2018.

Anaemia of acute inflammation: a higher acute systemic inflammatory response is associated with a larger decrease in blood haemoglobin levels in patients with COVID-19 infection (2023)
Journal Article
Crooks, C. J., West, J., Morling, J. R., Simmonds, M., Juurlink, I., Briggs, S., …Fogarty, A. W. (2023). Anaemia of acute inflammation: a higher acute systemic inflammatory response is associated with a larger decrease in blood haemoglobin levels in patients with COVID-19 infection. Clinical Medicine, 23(3), 201-205. https://doi.org/10.7861/clinmed.2022-0436

AIMS: The study tests the hypothesis that a higher acute systemic inflammatory response was associated with a larger decrease in blood hemoglobin levels in patients with Coronavirus 2019 (COVID-19) infection. METHODS: All patients with either suspect... Read More about Anaemia of acute inflammation: a higher acute systemic inflammatory response is associated with a larger decrease in blood haemoglobin levels in patients with COVID-19 infection.

Effects of statins and aspirin on HCC risk in alcohol-related cirrhosis: nationwide emulated trials (2023)
Journal Article
Kraglund, F., Christensen, D. H., Eiset, A. H., Villadsen, G. E., West, J., & Jepsen, P. (2023). Effects of statins and aspirin on HCC risk in alcohol-related cirrhosis: nationwide emulated trials. Hepatology Communications, 7(1), Article e0013. https://doi.org/10.1097/HC9.0000000000000013

Background and Aims: Observational studies have shown an association between statin or aspirin use and a decreased risk of HCC, but the effects of a well-defined treatment strategy remain unknown. We emulated trials of the effects of continuous stati... Read More about Effects of statins and aspirin on HCC risk in alcohol-related cirrhosis: nationwide emulated trials.

Inverse association between blood pressure and pulse oximetry accuracy: an observational study in patients with suspected or confirmed COVID-19 infection (2022)
Journal Article
Crooks, C. J., West, J., Morling, J., Simmonds, M., Juurlink, I., Briggs, S., …Fogarty, A. W. (2023). Inverse association between blood pressure and pulse oximetry accuracy: an observational study in patients with suspected or confirmed COVID-19 infection. Emergency Medicine Journal, 40(3), 216-220. https://doi.org/10.1136/emermed-2022-212443

Background Pulse oximeters are a standard non-invasive tool to measure blood oxygen levels, and are used in multiple healthcare settings. It is important to understand the factors affecting their accuracy to be able to use them optimally and safely.... Read More about Inverse association between blood pressure and pulse oximetry accuracy: an observational study in patients with suspected or confirmed COVID-19 infection.

Temporal Trends in the Incidence of Hemophagocytic Lymphohistiocytosis: A Nationwide Cohort Study From England 2003–2018 (2022)
Journal Article
West, J., Stilwell, P., Liu, H., Ban, L., Bythell, M., Card, T. R., …Crooks, C. J. (2022). Temporal Trends in the Incidence of Hemophagocytic Lymphohistiocytosis: A Nationwide Cohort Study From England 2003–2018. HemaSphere, 6(11), Article e797. https://doi.org/10.1097/HS9.0000000000000797

Hemophagocytic lymphohistiocytosis (HLH) is rare, results in high mortality, and is increasingly being diagnosed. We aimed to quantify the incidence of diagnosed HLH and examine temporal trends in relation to age and associated diseases. Using nation... Read More about Temporal Trends in the Incidence of Hemophagocytic Lymphohistiocytosis: A Nationwide Cohort Study From England 2003–2018.

Haemphagocytic Lymphohistiocytosis in an English Nationwide Cohort Confirms Increasing Incidence and Variation in Trigger Factors (2022)
Journal Article
Bishton, M., Crooks, C., Liu, H., Ban, L., Bythell, M., Card, T., …West, J. (2022). Haemphagocytic Lymphohistiocytosis in an English Nationwide Cohort Confirms Increasing Incidence and Variation in Trigger Factors. Blood, 140(Supplement 1), 2599-2600. https://doi.org/10.1182/blood-2022-158999

Background: Haemophagocytic Lymphohistiocytosis (HLH) is a rare, life-threatening hyper-inflammatory syndrome triggered by constitutive and acquired risk factors including haematological malignancy, infection, auto-immunity and rheumatological diseas... Read More about Haemphagocytic Lymphohistiocytosis in an English Nationwide Cohort Confirms Increasing Incidence and Variation in Trigger Factors.

Social support and risk of mortality in cirrhosis: A cohort study (2022)
Journal Article
Askgaard, G., Madsen, L. G., von Wowern, N., Winther-Jensen, M., Lau, C. J., Christensen, A. I., …Jepsen, P. (2023). Social support and risk of mortality in cirrhosis: A cohort study. JHEP Reports, 5(1), Article 100600. https://doi.org/10.1016/j.jhepr.2022.100600

Background & Aims The function and structure of social relationships influence mortality in individuals within the general population. We compared aspects of social relationships in patients with cirrhosis and a matched comparison c... Read More about Social support and risk of mortality in cirrhosis: A cohort study.

Long-term adverse effects and healthcare burden of rectal cancer radiotherapy: systematic review and meta-analysis (2022)
Journal Article
Morton, A. J., Rashid, A., Shim, J. S., West, J., Humes, D. J., & Grainge, M. J. (2023). Long-term adverse effects and healthcare burden of rectal cancer radiotherapy: systematic review and meta-analysis. ANZ Journal of Surgery, 93(1-2), 42-53. https://doi.org/10.1111/ans.18059

Background: As rectal cancer survival increases, more patients survive with potentially severe, long-term gastrointestinal and genitourinary complications from radiotherapy. The burden of these complications for patients and healthcare services is un... Read More about Long-term adverse effects and healthcare burden of rectal cancer radiotherapy: systematic review and meta-analysis.

Liver blood marker testing in UK primary care: a UK wide cohort study, 2004-2016 (2022)
Journal Article
Scutt, P., Ban, L., Card, T., Crooks, C. J., Guha, N., West, J., & Morling, J. R. (2022). Liver blood marker testing in UK primary care: a UK wide cohort study, 2004-2016. BMJ Open, 12(9), e058967. https://doi.org/10.1136/bmjopen-2021-058967

OBJECTIVE: We aimed to determine (1) the temporal trends of liver enzyme testing in UK general practice and (2) how these vary among different subgroups at risk of chronic liver disease (CLD). DESIGN: Retrospective cohort study. SETTING: UK primary c... Read More about Liver blood marker testing in UK primary care: a UK wide cohort study, 2004-2016.