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All Outputs (4)

Development of a Corynebacterium glutamicum bio-factory for self-sufficient transaminase reactions (2020)
Journal Article
Grigoriou, S., Kugler, P., Kulcinskaja, E., Walter, F., King, J., Hill, P., …O'Reilly, E. (2020). Development of a Corynebacterium glutamicum bio-factory for self-sufficient transaminase reactions. Green Chemistry, 22(13), 4128-4132. https://doi.org/10.1039/d0gc01432j

The development of biocatalytic routes for the synthesis of chiral amines starting from achiral building blocks is highly desirable. Here, we report a self-sufficient whole-cell system for the conversion of a model ketone to the corresponding cyclic... Read More about Development of a Corynebacterium glutamicum bio-factory for self-sufficient transaminase reactions.

Conversion of aldoses to valuable ?-amino alcohols using amine transaminase biocatalysts (2018)
Journal Article
Cairns, R., Gomm, A., Ryan, J., Clarke, T., Kulcinskaja, E., Butler, K., & O’Reilly, E. (2019). Conversion of aldoses to valuable ω-amino alcohols using amine transaminase biocatalysts. ACS Catalysis, 9(2), 1220-1223. https://doi.org/10.1021/acscatal.8b04564

The conversion of readily available monosaccharides to high-value amino alcohols using a key biocatalytic step is an attractive strategy for the preparation of these chiral synthons. Here, we report a previously undescribed example of the direct ami... Read More about Conversion of aldoses to valuable ?-amino alcohols using amine transaminase biocatalysts.

Application of 'smart' amine donors for rapid screening and scale-up of transaminase-mediated biotransformations (2018)
Journal Article
Gomm, A., Grigoriou, S., Peel, C., Ryan, J., Mujtaba, N., Clarke, T., …O'Reilly, E. (2018). Application of 'smart' amine donors for rapid screening and scale-up of transaminase-mediated biotransformations. European Journal of Organic Chemistry, 2018(38), 5282-5284. https://doi.org/10.1002/ejoc.201800799

The 'smart' amine donors o‐xylylenediamine and cadaverine were employed for the rapid screening of a large ketone library and subsequent preparative‐scale synthesis of selected compounds using the commercially available amine transaminase, ATA256. Th... Read More about Application of 'smart' amine donors for rapid screening and scale-up of transaminase-mediated biotransformations.

Tuneable 3D printed bioreactors for transaminations under continuous-flow (2017)
Journal Article
Peris, E., Okafor, O., Kulchinskaja, E., Goodridge, R. D., Luis, S. V., Garcia-Verdugo, E., …Sans, V. (2017). Tuneable 3D printed bioreactors for transaminations under continuous-flow. Green Chemistry, 19(22), https://doi.org/10.1039/C7GC02421E

A method to efficiently immobilize enzymes on 3D printed continuous-flow devices is presented. Application of these chemically modified devices enables rapid screening of immobilization mechanisms and reaction conditions, simple transfer of optimised... Read More about Tuneable 3D printed bioreactors for transaminations under continuous-flow.