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Fast Raman spectral mapping of highly fluorescing samples by time-gated spectral multiplexed detection (2018)
Journal Article
Corden, C. J., Shipp, D. W., Matousek, P., & Notingher, I. (2018). Fast Raman spectral mapping of highly fluorescing samples by time-gated spectral multiplexed detection. Optics Letters, 43(23), 5733-5736. https://doi.org/10.1364/ol.43.005733

We present a time-gated Raman micro-spectroscopy technique suitable for fast Raman mapping of samples eliciting large laser-induced fluorescence backgrounds. To achieve the required time resolution for effective fluorescence rejection, a picosecond p... Read More about Fast Raman spectral mapping of highly fluorescing samples by time-gated spectral multiplexed detection.

Intra-operative spectroscopic assessment of surgical margins during breast conserving surgery (2018)
Journal Article
Shipp, D. W., Rakha, E. A., Koloydenko, A. A., Macmillan, R. D., Ellis, I. O., & Notingher, I. (2018). Intra-operative spectroscopic assessment of surgical margins during breast conserving surgery. Breast Cancer Research, 20, https://doi.org/10.1186/s13058-018-1002-2

Background: In over 20% of breast conserving operations, postoperative pathological assessment of the excised tissue reveals positive margins, requiring additional surgery. Current techniques for intra-operative assessment of tumor margins are insuff... Read More about Intra-operative spectroscopic assessment of surgical margins during breast conserving surgery.

Automated multimodal spectral histopathology for quantitative diagnosis of residual tumour during basal cell carcinoma surgery (2017)
Journal Article
Boitor, R., Kong, K., Shipp, D., Varma, S., Koloydenko, A., Kusum, K., …Ioan, N. (in press). Automated multimodal spectral histopathology for quantitative diagnosis of residual tumour during basal cell carcinoma surgery. Biomedical Optics Express, 8(12), https://doi.org/10.1364/BOE.8.005749

Multimodal spectral histopathology (MSH), an optical technique combining tissue auto-fluorescence (AF) imaging and Raman micro-spectroscopy (RMS), was previously proposed for detection of residual basal cell carcinoma (BCC) at the surface of surgical... Read More about Automated multimodal spectral histopathology for quantitative diagnosis of residual tumour during basal cell carcinoma surgery.

Label-free Raman hyperspectral imaging of single cells cultured on polymer substrates (2017)
Journal Article
Sinjab, F., Sicilia, G., Shipp, D., Marlow, M., & Notingher, I. (2017). Label-free Raman hyperspectral imaging of single cells cultured on polymer substrates. Applied Spectroscopy, 71(12), https://doi.org/10.1177/0003702817715042

While Raman hyper-spectral imaging has been widely used for label-free mapping of biomolecules in cells, these measurements require the cells to be cultured on weakly Raman scattering substrates. However, many applications in biological sciences and... Read More about Label-free Raman hyperspectral imaging of single cells cultured on polymer substrates.

Raman spectroscopy: techniques and applications in the life sciences (2017)
Journal Article
Shipp, D., Sinjab, F., & Notingher, I. (2017). Raman spectroscopy: techniques and applications in the life sciences. Advances in Optics and Photonics, 9(2), 315-428. https://doi.org/10.1364/AOP.9.000315

Raman spectroscopy is an increasingly popular technique in many areas including biology and medicine. It is based on Raman scattering, a phenomenon in which incident photons lose or gain energy via interactions with vibrating molecules in a sample. T... Read More about Raman spectroscopy: techniques and applications in the life sciences.