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The critical role of technologies in neonatal care (2023)
Journal Article
Taha, S., Simpson, R. B., & Sharkey, D. (2023). The critical role of technologies in neonatal care. Early Human Development, 187, Article 105898. https://doi.org/10.1016/j.earlhumdev.2023.105898

Neonatal care has made significant advances in the last few decades. As a result, mortality and morbidity in high-risk infants, such as extremely preterm infants or those infants with birth-related brain injury, has reduced significantly. Many of the... Read More about The critical role of technologies in neonatal care.

Association between opioid use during mechanical ventilation in preterm infants and evidence of brain injury: a propensity score-matched cohort study (2023)
Journal Article
Szatkowski, L., Sharkey, D., Budge, H., & Ojha, S. (2023). Association between opioid use during mechanical ventilation in preterm infants and evidence of brain injury: a propensity score-matched cohort study. eClinicalMedicine, 65, Article 102296. https://doi.org/10.1016/j.eclinm.2023.102296

Background: Preterm infants often require mechanical ventilation (MV), which can be a painful experience. Opioids (such as morphine) are used to provide analgesia, despite conflicting evidence about their impact on the developing brain. We aimed to q... Read More about Association between opioid use during mechanical ventilation in preterm infants and evidence of brain injury: a propensity score-matched cohort study.

Identifying Variation in the Newborn Life Support Procedure: An Automated Method (2023)
Conference Proceeding
Tan, A., Remenyte-Prescott, R., Egede, J., Valstar, M., & Sharkey, D. (2023). Identifying Variation in the Newborn Life Support Procedure: An Automated Method. In M. P. Brito, T. Aven, P. Baraldi, M. Čepin, & E. Zio (Eds.), Proceedings of the 33rd European Safety and Reliability Conference (ESREL 2023) (607-614)

This research is conducted for developing an automated method to recognize variations in the Newborn Life Support (NLS) procedure. Compliance with the NLS standard guideline is essential to prevent any adverse consequences for the newborn. Video reco... Read More about Identifying Variation in the Newborn Life Support Procedure: An Automated Method.

Respiratory management and outcomes in high-risk preterm infants with development of a population outcome dashboard (2023)
Journal Article
Kwok, T. C., Poulter, C., Algarni, S., Szatkowski, L., & Sharkey, D. (2023). Respiratory management and outcomes in high-risk preterm infants with development of a population outcome dashboard. Thorax, 78(12), 1215–1222. https://doi.org/10.1136/thorax-2023-220174

Introduction: Bronchopulmonary dysplasia (BPD) is associated with adverse long-term respiratory and neurodevelopmental outcomes. No recent studies examined the changing respiratory management and outcomes, particularly severe BPD, across a whole popu... Read More about Respiratory management and outcomes in high-risk preterm infants with development of a population outcome dashboard.

Impact of postnatal dexamethasone timing on preterm mortality and bronchopulmonary dysplasia: a propensity score analysis (2023)
Journal Article
Kwok, T. C., Szatkowski, L., & Sharkey, D. (in press). Impact of postnatal dexamethasone timing on preterm mortality and bronchopulmonary dysplasia: a propensity score analysis. European Respiratory Journal, https://doi.org/10.1183/13993003.00825-2023

Introduction Postnatal dexamethasone (PND) is used in high-risk preterm infants after the first week of life to facilitate extubation and prevent bronchopulmonary dysplasia (BPD) but the optimal treatment timing remains unclear. Objective Explore... Read More about Impact of postnatal dexamethasone timing on preterm mortality and bronchopulmonary dysplasia: a propensity score analysis.

The Classification of Movement in Infants for the Autonomous Monitoring of Neurological Development (2023)
Journal Article
Turner, A., Hayes, S., & Sharkey, D. (2023). The Classification of Movement in Infants for the Autonomous Monitoring of Neurological Development. Sensors, 23(10), Article 4800. https://doi.org/10.3390/s23104800

Neurodevelopmental delay following extremely preterm birth or birth asphyxia is common but diagnosis is often delayed as early milder signs are not recognised by parents or clinicians. Early interventions have been shown to improve outcomes. Automati... Read More about The Classification of Movement in Infants for the Autonomous Monitoring of Neurological Development.

A modelling approach to studying variations in newborn life support procedure (2023)
Journal Article
Tan, A., Remenyte-Prescott, R., Valstar, M., & Sharkey, D. (2023). A modelling approach to studying variations in newborn life support procedure. Proceedings of the Institution of Mechanical Engineers, Part O: Journal of Risk and Reliability, https://doi.org/10.1177/1748006X231173595

Variations in clinical practice are common. However, some variations may cause undesired consequences. Careful consideration of their causes and effects is necessary to assure the quality of healthcare delivery. A modelling approach that could captur... Read More about A modelling approach to studying variations in newborn life support procedure.

Forehead monitoring of heart rate in neonatal intensive care (2023)
Journal Article
Stockwell, S. J., Kwok, T. C., Morgan, S. P., Sharkey, D., & Hayes-Gill, B. R. (2023). Forehead monitoring of heart rate in neonatal intensive care. Frontiers in Physiology, 14, Article 1127419. https://doi.org/10.3389/fphys.2023.1127419

Heart rate is an extremely important physiological parameter to measure in critically unwell infants, as it is the main physiological marker that changes in response to a change in infant condition. Heart rate is routinely measured peripherally on a... Read More about Forehead monitoring of heart rate in neonatal intensive care.

Complex roles of TGF-β signaling pathways in lung development and bronchopulmonary dysplasia (2023)
Journal Article
Calthorpe, R. J., Poulter, C., Smyth, A. R., Sharkey, D., Bhatt, J., Jenkins, G., & Tatler, A. L. (2023). Complex roles of TGF-β signaling pathways in lung development and bronchopulmonary dysplasia. AJP - Lung Cellular and Molecular Physiology, 324(3), L285-L296. https://doi.org/10.1152/ajplung.00106.2021

As survival of extremely preterm infants continues to improve, there is also an associated increase in bronchopulmonary dysplasia (BPD), one of the most significant complications of preterm birth. BPD development is multifactorial resulting from expo... Read More about Complex roles of TGF-β signaling pathways in lung development and bronchopulmonary dysplasia.

Observational cohort study of use of caffeine in preterm infants and association between early caffeine use and neonatal outcomes (2023)
Journal Article
Szatkowski, L., Fateh, S., Abramson, J., Kwok, T. C., Sharkey, D., Budge, H., & Ojha, S. (2023). Observational cohort study of use of caffeine in preterm infants and association between early caffeine use and neonatal outcomes. Archives of Disease in Childhood. Fetal and Neonatal Edition, 108(5), 505-510. https://doi.org/10.1136/archdischild-2022-324919

Objective: To quantify trends in caffeine use in infants born at

Bronchopulmonary dysplasia prediction models: a systematic review and meta-analysis with validation (2023)
Journal Article
Kwok, T. C., Batey, N., Luu, K. L., Prayle, A., & Sharkey, D. (2023). Bronchopulmonary dysplasia prediction models: a systematic review and meta-analysis with validation. Pediatric Research, 94, 43–54. https://doi.org/10.1038/s41390-022-02451-8

Abstract: Prediction models could identify infants at the greatest risk of bronchopulmonary dysplasia (BPD) and allow targeted preventative strategies. We performed a systematic review and meta-analysis with external validation of identified models.... Read More about Bronchopulmonary dysplasia prediction models: a systematic review and meta-analysis with validation.

Artificial intelligence-driven wearable technologies for neonatal cardiorespiratory monitoring: Part 1 wearable technology (2023)
Journal Article
Grooby, E., Sitaula, C., Chang Kwok, T., Sharkey, D., Marzbanrad, F., & Malhotra, A. (2023). Artificial intelligence-driven wearable technologies for neonatal cardiorespiratory monitoring: Part 1 wearable technology. Pediatric Research, 93(2), 413-425. https://doi.org/10.1038/s41390-022-02416-x

Abstract: With the development of Artificial Intelligence techniques, smart health monitoring is becoming more popular. In this study, we investigate the trend of wearable sensors being adopted and developed in neonatal cardiorespiratory monitoring.... Read More about Artificial intelligence-driven wearable technologies for neonatal cardiorespiratory monitoring: Part 1 wearable technology.

Artificial intelligence-driven wearable technologies for neonatal cardiorespiratory monitoring. Part 2: artificial intelligence (2022)
Journal Article
Sitaula, C., Grooby, E., Kwok, T. C., Sharkey, D., Marzbanrad, F., & Malhotra, A. (2023). Artificial intelligence-driven wearable technologies for neonatal cardiorespiratory monitoring. Part 2: artificial intelligence. Pediatric Research, 93(2), 426-436. https://doi.org/10.1038/s41390-022-02417-w

Background: With the development of Artificial Intelligence (AI) techniques, smart health monitoring, particularly neonatal cardiorespiratory monitoring with wearable devices, is becoming more popular. To this end, it is crucial to investigate the tr... Read More about Artificial intelligence-driven wearable technologies for neonatal cardiorespiratory monitoring. Part 2: artificial intelligence.

Neonatal stroke surveillance study protocol in the United Kingdom and Republic of Ireland (2022)
Journal Article
Kwok, T. C., Dineen, R. A., Whitehouse, W., Lynn, R. M., McSweeney, N., & Sharkey, D. (2022). Neonatal stroke surveillance study protocol in the United Kingdom and Republic of Ireland. Open Medicine, 17(1), 1417-1424. https://doi.org/10.1515/med-2022-0554

Neonatal stroke is a devastating condition that causes brain injury in babies and often leads to lifelong neurological impairment. Recent prospective population studies of neonatal stroke are lacking. Neonatal strokes are different from those in olde... Read More about Neonatal stroke surveillance study protocol in the United Kingdom and Republic of Ireland.

Modelling Variations in Newborn Life Support Procedure Using Colored Petri Nets (2022)
Conference Proceeding
Leva, M. C., Patelli, E., Podofillini, L., Wilson, S., Tan, A., Remenyte-Prescott, R., …Sharkey, D. (2022). Modelling Variations in Newborn Life Support Procedure Using Colored Petri Nets. In M. Chiara Leva, E. Patelli, L. Podofillini, & S. Wilson (Eds.), Proceedings of the 32nd European Safety and Reliability Conference (ESREL 2022) (489-496). https://doi.org/10.3850/978-981-18-5183-4_R12-08-152-cd

This research is conducted to study variations in the Newborn Life Support procedure. This procedure follows an evidence-based protocol to resuscitate and stabilize newborn babies requiring assistance at birth. Errors and ineffective actions in this... Read More about Modelling Variations in Newborn Life Support Procedure Using Colored Petri Nets.

Implementation of Public Health England infection prevention and control guidance in maternity units in response to the COVID-19 pandemic (2022)
Journal Article
Hanley, S. J., Jones, A. B., Oberman, J., Baxter, E., Sharkey, D., Gray, J., & Walker, K. F. (2022). Implementation of Public Health England infection prevention and control guidance in maternity units in response to the COVID-19 pandemic. Journal of Hospital Infection, https://doi.org/10.1016/j.jhin.2022.04.018

Background: This study aimed to explore the successes and barriers to the implementation of Public Health England (PHE) infection prevention and control guidance in English maternity units during the COVID-19 pandemic. Methods: Qualitative semi-struc... Read More about Implementation of Public Health England infection prevention and control guidance in maternity units in response to the COVID-19 pandemic.

Maternity services' responses to the COVID-19 pandemic: how Public Health England guidance was implemented in practice (2022)
Journal Article
Hanley, S., Raybould, G., Baxter, E., Gray, J., Sharkey, D., & Walker, K. F. (2022). Maternity services' responses to the COVID-19 pandemic: how Public Health England guidance was implemented in practice. Journal of Hospital Infection, https://doi.org/10.1016/j.jhin.2022.04.019

Introduction: The rapidly evolving COVID-19 pandemic required systemic change in how healthcare was delivered to minimize virus transmission whilst maintaining safe service delivery. Deemed at ‘moderate-high risk’, maternity patients are an important... Read More about Maternity services' responses to the COVID-19 pandemic: how Public Health England guidance was implemented in practice.

Application and potential of artificial intelligence in neonatal medicine (2022)
Journal Article
Chang Kwok, T., Henry, C., Saffaran, S., Meeus, M., Bates, D., Van Laere, D., …Sharkey, D. (2022). Application and potential of artificial intelligence in neonatal medicine. Seminars in Fetal and Neonatal Medicine, 27(5), Article 101346. https://doi.org/10.1016/j.siny.2022.101346

Neonatal care is becoming increasingly complex with large amounts of rich, routinely recorded physiological, diagnostic and outcome data. Artificial intelligence (AI) has the potential to harness this vast quantity and range of information and become... Read More about Application and potential of artificial intelligence in neonatal medicine.

Availability of active therapeutic hypothermia at birth for neonatal hypoxic ischaemic encephalopathy: a UK population study from 2011 to 2018 (2022)
Journal Article
Mistry, A., Shipley, L., Ojha, S., & Sharkey, D. (2022). Availability of active therapeutic hypothermia at birth for neonatal hypoxic ischaemic encephalopathy: a UK population study from 2011 to 2018. Archives of Disease in Childhood. Fetal and Neonatal Edition, 107(6), 597-602. https://doi.org/10.1136/archdischild-2021-322906

Objective: Therapeutic hypothermia (TH) commenced soon after birth for neonatal hypoxic ischaemic encephalopathy (HIE) improves survival and reduces neurodisability. Availability of active TH at the place of birth (Immediate-TH) in the UK is unknown.... Read More about Availability of active therapeutic hypothermia at birth for neonatal hypoxic ischaemic encephalopathy: a UK population study from 2011 to 2018.

Feasibility of a Novel ECG Electrode Placement Method in Newborn Infants (2022)
Journal Article
Henry, C., Shipley, L., Morgan, S., Crowe, J. A., Carpenter, J., Hayes-Gill, B., & Sharkey, D. (2022). Feasibility of a Novel ECG Electrode Placement Method in Newborn Infants. Neonatology, 119(2), 264-267. https://doi.org/10.1159/000521530

Background: International newborn resuscitation guidelines recommend electrocardiogram (ECG) heart rate (HR) monitoring at birth. We evaluated the application time of pre-set ECG electrodes fixed to a polyethene patch allowing adhesive-free attachmen... Read More about Feasibility of a Novel ECG Electrode Placement Method in Newborn Infants.