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All Outputs (8)

The beta-adrenergic agonist, Ractopamine increases skeletal muscle expression of Asparagine Synthetase as part of an integrated stress response gene program (2018)
Journal Article
Brown, D., Ryan, K., Daniel, Z., Mareko, M., Talbot, R., Moreton, J., …Brameld, J. M. (2018). The beta-adrenergic agonist, Ractopamine increases skeletal muscle expression of Asparagine Synthetase as part of an integrated stress response gene program. Scientific Reports, 8, Article 15915. https://doi.org/10.1038/s41598-018-34315-9

Synthetic beta-adrenergic agonists (BA) have broad biomedical and agricultural application for increasing lean body mass, yet a poor understanding of the biology underpinning these agents is limiting further drug discovery potential. Growing female p... Read More about The beta-adrenergic agonist, Ractopamine increases skeletal muscle expression of Asparagine Synthetase as part of an integrated stress response gene program.

Effect of sodium 4-phenylbutyrate on clenbuterol-mediated muscle growth (2018)
Journal Article
Brown, D. M., Jones, S., Daniel, Z. C., Brearley, M. C., Lewis, J. E., Ebling, F. J., …Brameld, J. M. (2018). Effect of sodium 4-phenylbutyrate on clenbuterol-mediated muscle growth. PLoS ONE, 13(7), Article e0201481. https://doi.org/10.1371/journal.pone.0201481

Previously, we highlighted induction of an integrated stress response (ISR) gene program in skeletal muscle of pigs treated with a beta-adrenergic agonist. Hence we tested the hypothesis that the ER-stress inhibitor, sodium 4-phenylbutyrate (PBA), wo... Read More about Effect of sodium 4-phenylbutyrate on clenbuterol-mediated muscle growth.

Immune infiltration in invasive lobular breast cancer (2018)
Journal Article
Desmedt, C., Salgado, R., Fornili, M., Pruneri, G., Gert Van den Eynden, G., Zoppoli, G., …Sotiriou, C. (2018). Immune infiltration in invasive lobular breast cancer. JNCI: Journal of the National Cancer Institute, 110(7), 768–776. https://doi.org/10.1093/jnci/djx268

Background: Invasive lobular breast cancer (ILC) is the second most common histological subtype of breast cancer after invasive ductal cancer (IDC). Here, we aimed at evaluating the prevalence, levels and composition of tumor infiltrating lymphocytes... Read More about Immune infiltration in invasive lobular breast cancer.

Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth (2016)
Journal Article
Brown, D. M., Williams, H., Ryan, K., Wilson, T., Daniel, Z. C., Mareko, M. H. D., …Parr, T. (2016). Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth. Scientific Reports, 6(1), https://doi.org/10.1038/srep28693

We aimed to identify novel molecular mechanisms for muscle growth during administration of anabolic agents. Growing pigs (Duroc/(Landrace/Large-White)) were administered Ractopamine (a beta-adrenergic agonist; BA; 20 ppm in feed) or Reporcin (recombi... Read More about Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth.

The impact of growth promoters on muscle growth and the potential consequences for meat quality (2016)
Journal Article
Parr, T., Mareko, M. H., Ryan, K. J., Hemmings, K. M., Brown, D. M., & Brameld, J. M. (2016). The impact of growth promoters on muscle growth and the potential consequences for meat quality. Meat Science, 120, 93-99. doi:10.1016/j.meatsci.2016.04.022

To meet the demands of increased global meat consumption, animal production systems will have to become more efficient, or at least maintain the current efficiency utilizing feed ingredients that are not also used for human consumption. Use of growth... Read More about The impact of growth promoters on muscle growth and the potential consequences for meat quality.

Adapting a humanoid robot for use with children with profound and multiple disabilities (2016)
Conference Proceeding
Standen, P. J., Brown, D. J., Hedgecock, J., Roscoe, J., Galvez Trigo, M. J., & Elgajiji, E. (2016). Adapting a humanoid robot for use with children with profound and multiple disabilities.

With all the developments in information technology (IT) for people with disabilities, few interventions have been designed for people with profound and multiple disabilities as there is little incentive for companies to design and manufacture techno... Read More about Adapting a humanoid robot for use with children with profound and multiple disabilities.

Patients' use of a home-based virtual reality system to provide rehabilitation of the upper limb following stroke (2015)
Journal Article
Standen, P., Threapleton, K., Connell, L. A., Richardson, A., Brown, D. J., Battersby, S., …Platts, F. (2015). Patients' use of a home-based virtual reality system to provide rehabilitation of the upper limb following stroke. Physical Therapy, 95(3), https://doi.org/10.2522/ptj.20130564

Objective Effectiveness depends on adherence, so did patients use the intervention to the recommended level? If not, what reasons did they give? The purpose of this study was to investigate these and related questions. Design A prospective c... Read More about Patients' use of a home-based virtual reality system to provide rehabilitation of the upper limb following stroke.

Expression of the myosin heavy chain IIB gene in porcine skeletal muscle: the role of the CArG-box promoter response element (2014)
Journal Article
Brown, D. M., Brameld, J. M., & Parr, T. (2014). Expression of the myosin heavy chain IIB gene in porcine skeletal muscle: the role of the CArG-box promoter response element. PLoS ONE, 9(12), Article e114365. https://doi.org/10.1371/journal.pone.0114365

Due to its similarity to humans, the pig is increasingly being considered as a good animal model for studying a range of human diseases. Despite their physiological similarities, differential expression of the myosin heavy chain (MyHC) IIB gene (MYH4... Read More about Expression of the myosin heavy chain IIB gene in porcine skeletal muscle: the role of the CArG-box promoter response element.