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All Outputs (13)

Evaluation of Host Defense Peptide (CaD23)-Antibiotic Interaction and Mechanism of Action: Insights From Experimental and Molecular Dynamics Simulations Studies (2021)
Journal Article
Ting, D. S. J., Li, J., Verma, C. S., Goh, E. T., Nubile, M., Mastropasqua, L., …Dua, H. S. (2021). Evaluation of Host Defense Peptide (CaD23)-Antibiotic Interaction and Mechanism of Action: Insights From Experimental and Molecular Dynamics Simulations Studies. Frontiers in Pharmacology, 12, Article 731499. https://doi.org/10.3389/fphar.2021.731499

Background/Aim: Host defense peptides (HDPs) have the potential to provide a novel solution to antimicrobial resistance (AMR) in view of their unique and broad-spectrum antimicrobial activities. We had recently developed a novel hybrid HDP based on L... Read More about Evaluation of Host Defense Peptide (CaD23)-Antibiotic Interaction and Mechanism of Action: Insights From Experimental and Molecular Dynamics Simulations Studies.

Hybrid derivative of cathelicidin and human beta defensin-2 against Gram-positive bacteria: A novel approach for the treatment of bacterial keratitis (2021)
Journal Article
Ting, D. S. J., Leng, E. T., Mayandi, V., Busoy, J. M. F., Aung, T. T., Periayah, M. H., …Dua, H. S. (2021). Hybrid derivative of cathelicidin and human beta defensin-2 against Gram-positive bacteria: A novel approach for the treatment of bacterial keratitis. Scientific Reports, 11, Article 18304. https://doi.org/10.1038/s41598-021-97821-3

Bacterial keratitis (BK) is a major cause of corneal blindness globally. This study aimed to develop a novel class of antimicrobial therapy, based on human-derived hybrid host defense peptides (HyHDPs), for treating BK. HyHDPs were rationally designe... Read More about Hybrid derivative of cathelicidin and human beta defensin-2 against Gram-positive bacteria: A novel approach for the treatment of bacterial keratitis.

Risk Factors, Clinical Outcomes, and Prognostic Factors of Bacterial Keratitis: The Nottingham Infectious Keratitis Study (2021)
Journal Article
Ting, D. S. J., Cairns, J., Gopal, B. P., Shan Ho, C. S., Krstic, L., Elsahn, A., …Dua, H. S. (2021). Risk Factors, Clinical Outcomes, and Prognostic Factors of Bacterial Keratitis: The Nottingham Infectious Keratitis Study. Frontiers in Medicine, 8, Article 715118. https://doi.org/10.3389/fmed.2021.715118

Background/Aim: To examine the risk factors, clinical characteristics, outcomes, and prognostic factors of bacterial keratitis (BK) in Nottingham, UK. Methods: This was a retrospective study of patients who presented to the Queen's Medical Centre, No... Read More about Risk Factors, Clinical Outcomes, and Prognostic Factors of Bacterial Keratitis: The Nottingham Infectious Keratitis Study.

Post-keratoplasty Infectious Keratitis: Epidemiology, Risk Factors, Management, and Outcomes (2021)
Journal Article
Song, A., Deshmukh, R., Lin, H., Ang, M., Mehta, J. S., Chodosh, J., …Ting, D. S. (2021). Post-keratoplasty Infectious Keratitis: Epidemiology, Risk Factors, Management, and Outcomes. Frontiers in Medicine, 8, Article 707242. https://doi.org/10.3389/fmed.2021.707242

Post-keratoplasty infectious keratitis (PKIK) represents a unique clinical entity that often poses significant diagnostic and therapeutic challenges. It carries a high risk of serious complications such as graft rejection and failure, and less common... Read More about Post-keratoplasty Infectious Keratitis: Epidemiology, Risk Factors, Management, and Outcomes.

Virtual consultation for red eye (2021)
Journal Article
Ho, C. S., Avery, A. J., Livingstone, I. A., & Ting, D. S. (2021). Virtual consultation for red eye. BMJ, 373, Article n1490. https://doi.org/10.1136/bmj.n1490

This article was written with the aim of helping primary care doctors to reflect on their knowledge and skills in managing common ophthalmic condition such as red eye in the community via virtual consultations. Expert opinions (from both ophthalmolog... Read More about Virtual consultation for red eye.

Amniotic membrane transplantation for infectious keratitis: a systematic review and meta-analysis (2021)
Journal Article
Ting, D. S. J., Henein, C., Said, D. G., & Dua, H. S. (2021). Amniotic membrane transplantation for infectious keratitis: a systematic review and meta-analysis. Scientific Reports, 11, Article 13007. https://doi.org/10.1038/s41598-021-92366-x

Infectious keratitis (IK) is the 5th leading cause of blindness globally. Broad-spectrum topical antimicrobial treatment is the current mainstay of treatment for IK, though adjuvant treatment or surgeries are often required in refractory cases of IK.... Read More about Amniotic membrane transplantation for infectious keratitis: a systematic review and meta-analysis.

Real-world experience of using ciclosporin-A 0.1% (Ikervis) in the management of ocular surface inflammatory diseases (2021)
Journal Article
Deshmukh, R., Ting, D. S. J., Elsahn, A., Mohammed, I., Said, D. G., & Dua, H. S. (2022). Real-world experience of using ciclosporin-A 0.1% (Ikervis) in the management of ocular surface inflammatory diseases. British Journal of Ophthalmology, 106(8), 1087-1092. https://doi.org/10.1136/bjophthalmol-2020-317907

Purpose: To report the real-world experience of using topical ciclosporin, Ikervis, in the management of ocular surface inflammatory diseases (OSIDs). Methods: This was a retrospective study of patients treated with Ikervis for OSIDs at the Queen’... Read More about Real-world experience of using ciclosporin-A 0.1% (Ikervis) in the management of ocular surface inflammatory diseases.

Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance (2021)
Journal Article
Ting, D. S. J., Ho, C. S., Deshmukh, R., Said, D. G., & Dua, H. S. (2021). Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance. Eye, 35, 1084-1101. https://doi.org/10.1038/s41433-020-01339-3

Corneal opacity is the 5th leading cause of blindness and visual impairment globally, affecting ~6 million of the world population. In addition, it is responsible for 1.5–2.0 million new cases of monocular blindness per year, highlighting an ongoing... Read More about Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance.

Seasonal patterns of incidence, demographic factors and microbiological profiles of infectious keratitis: the Nottingham Infectious Keratitis Study (2020)
Journal Article
Ting, D. S. J., Ho, C. S., Cairns, J., Gopal, B. P., Elsahn, A., Al-Aqaba, M., …Dua, H. S. (2021). Seasonal patterns of incidence, demographic factors and microbiological profiles of infectious keratitis: the Nottingham Infectious Keratitis Study. Eye, 35(9), 2543-2549. https://doi.org/10.1038/s41433-020-01272-5

Purpose: The purpose of this study is to examine the seasonal patterns of incidence, demographic factors and microbiological profiles of infectious keratitis (IK) in Nottingham, UK. Methods: A retrospective study of all patients who were diagnosed wi... Read More about Seasonal patterns of incidence, demographic factors and microbiological profiles of infectious keratitis: the Nottingham Infectious Keratitis Study.

Potential of mesenchymal stem cells as topical immunomodulatory cell therapies for ocular surface inflammatory disorders (2020)
Journal Article
Beeken, L. J., Ting, D. S. J., & Sidney, L. E. (2020). Potential of mesenchymal stem cells as topical immunomodulatory cell therapies for ocular surface inflammatory disorders. Stem Cells Translational Medicine, 10(1), 39-49. https://doi.org/10.1002/sctm.20-0118

Ocular surface inflammatory disorders (OSIDs) are a group of highly prevalent, heterogeneous diseases which display a variety of aetiologies and symptoms and are risk factors for serious complications including ocular and cornea impairment. Corneal i... Read More about Potential of mesenchymal stem cells as topical immunomodulatory cell therapies for ocular surface inflammatory disorders.

12-year analysis of incidence, microbiological profiles and in vitro antimicrobial susceptibility of infectious keratitis: the Nottingham Infectious Keratitis Study (2020)
Journal Article
Ting, D. S. J., Ho, C. S., Cairns, J., Elsahn, A., Al-Aqaba, M. A., Boswell, T., …Dua, H. (2021). 12-year analysis of incidence, microbiological profiles and in vitro antimicrobial susceptibility of infectious keratitis: the Nottingham Infectious Keratitis Study. British Journal of Ophthalmology, 105(3), 328-333. https://doi.org/10.1136/bjophthalmol-2020-316128

Background/aims: To examine the incidence, causative microorganisms and in vitro antimicrobial susceptibility and resistance profiles of infectious keratitis (IK) in Nottingham, UK. Methods: A retrospective study of all patients who were diagnosed... Read More about 12-year analysis of incidence, microbiological profiles and in vitro antimicrobial susceptibility of infectious keratitis: the Nottingham Infectious Keratitis Study.

Strategies in Translating the Therapeutic Potentials of Host Defense Peptides (2020)
Journal Article
Ting, D. S. J., Beuerman, R. W., Dua, H. S., Lakshminarayanan, R., & Mohammed, I. (2020). Strategies in Translating the Therapeutic Potentials of Host Defense Peptides. Frontiers in Immunology, 11, https://doi.org/10.3389/fimmu.2020.00983

The golden era of antibiotics, heralded by the discovery of penicillin, has long been challenged by the emergence of antimicrobial resistance (AMR). Host defense peptides (HDPs), previously known as antimicrobial peptides, are emerging as a group of... Read More about Strategies in Translating the Therapeutic Potentials of Host Defense Peptides.