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New Microfluidic System for Electrochemical Impedance Spectroscopy Assessment of Cell Culture Performance: Design and Development of New Electrode Material (2022)
Journal Article
Chmayssem, A., Tanase, C. E., Verplanck, N., Gougis, M., Mourier, V., Zebda, A., …Mailley, P. (2022). New Microfluidic System for Electrochemical Impedance Spectroscopy Assessment of Cell Culture Performance: Design and Development of New Electrode Material. Biosensors, 12(7), Article 452. https://doi.org/10.3390/bios12070452

Electrochemical impedance spectroscopy (EIS) is widely accepted as an effective and non-destructive method to assess cell health during cell-culture. However, there is a lack of compact devices compatible with microfluidic integration and microscopy... Read More about New Microfluidic System for Electrochemical Impedance Spectroscopy Assessment of Cell Culture Performance: Design and Development of New Electrode Material.

Development of a multiparametric (bio)sensing platform for continuous monitoring of stress metabolites (2021)
Journal Article
Chmayssem, A., Verplanck, N., Tanase, C. E., Costa, G., Monsalve-Grijalba, K., Amigues, S., …Mailley, P. (2021). Development of a multiparametric (bio)sensing platform for continuous monitoring of stress metabolites. Talanta, 229, Article 122275. https://doi.org/10.1016/j.talanta.2021.122275

There is a growing need for real-time monitoring of metabolic products that could reflect cell damages over extended periods. In this paper, we report the design and development of an original multiparametric (bio)sensing platform that is tailored fo... Read More about Development of a multiparametric (bio)sensing platform for continuous monitoring of stress metabolites.

Targeted protein delivery: carbodiimide crosslinking influences protein release from microparticles incorporated within collagen scaffolds (2019)
Journal Article
Tanase, C. E., Qutachi, O., White, L. J., Shakesheff, K. M., McCaskie, A. W., Best, S. M., & Cameron, R. E. (2019). Targeted protein delivery: carbodiimide crosslinking influences protein release from microparticles incorporated within collagen scaffolds. Regenerative Biomaterials, 6(5), 279-287. https://doi.org/10.1093/rb/rbz015

Tissue engineering response may be tailored via controlled, sustained release of active agents from protein loaded degradable microparticles incorporated directly within 3D ice-templated collagen scaffolds. However, the effects of covalent crosslink... Read More about Targeted protein delivery: carbodiimide crosslinking influences protein release from microparticles incorporated within collagen scaffolds.

Cell response to plasma electrolytic oxidation surface-modified low-modulus ?-type titanium alloys (2018)
Journal Article
Tanase, C., Golozar, M., Best, S., & Brooks, R. (2021). Cell response to plasma electrolytic oxidation surface-modified low-modulus ?-type titanium alloys. Colloids and Surfaces B: Biointerfaces, 176, 176-184. https://doi.org/10.1016/j.colsurfb.2018.12.064

Plasma electrolytic oxidation (PEO) has been demonstrated to be an effective surface treatment for enhancing the osteoconduction and osseointegration of commercially pure ?-Ti (CP ?-Ti) dental implant materials for clinical application. To explore th... Read More about Cell response to plasma electrolytic oxidation surface-modified low-modulus ?-type titanium alloys.

Photocrosslinkable gelatin hydrogels modulate the production of the major pro-inflammatory cytokine, TNF-α, by human mononuclear cells (2018)
Journal Article
Donaldson, A. R., Edi Tanase, C., Awuah, D., Vasanthi Bathri Narayanan, P., Hall, L., Nikkhah, M., …Ghaemmaghami, A. M. (2018). Photocrosslinkable gelatin hydrogels modulate the production of the major pro-inflammatory cytokine, TNF-α, by human mononuclear cells. Frontiers in Bioengineering and Biotechnology, 6, Article 116. https://doi.org/10.3389/fbioe.2018.00116

Hydrogels are an attractive class of biomaterials in tissue engineering due to their inherently compatible properties for cell culture. Gelatin methacryloyl (GelMA) has shown significant promise in the fields of tissue engineering and drug delivery,... Read More about Photocrosslinkable gelatin hydrogels modulate the production of the major pro-inflammatory cytokine, TNF-α, by human mononuclear cells.

Stiffening by Osmotic Swelling Constraint in Cartilage-Like Cell Culture Scaffolds (2018)
Journal Article
Offeddu, G. S., Tanase, C. E., Toumpaniari, S., Oyen, M. L., & Cameron, R. E. (2018). Stiffening by Osmotic Swelling Constraint in Cartilage-Like Cell Culture Scaffolds. Macromolecular Bioscience, 18, https://doi.org/10.1002/mabi.201800247

Abstract Cartilage wounds result in chronic pain and degradation of the quality of life for millions of people. A synthetic cellular scaffold able to heal the damage by substituting the natural tissue is of great potential value. Here, it is shown fo... Read More about Stiffening by Osmotic Swelling Constraint in Cartilage-Like Cell Culture Scaffolds.

Design, characterization and preliminary biological evaluation of new lignin-PLA biocomposites (2018)
Journal Article
Spiridon, I., & Tanase, C. E. (2018). Design, characterization and preliminary biological evaluation of new lignin-PLA biocomposites. International Journal of Biological Macromolecules, 114, 855-863. https://doi.org/10.1016/j.ijbiomac.2018.03.140

The study focuses on the obtainment of new poly (lactic acid)-lignin biocomposites. The effect of lignin loading on the morphology and mechanical properties, as well as the water uptake behaviour of the obtained biocomposites, was investigated in ord... Read More about Design, characterization and preliminary biological evaluation of new lignin-PLA biocomposites.

A novel biphasic scaffold supports meniscal tissue repair in ex vivo and in vivo models (2016)
Journal Article
Tanase, C. E., Wardale, J., & Henson, F. M. D. (2016). A novel biphasic scaffold supports meniscal tissue repair in ex vivo and in vivo models. Musculoskeletal Regeneration, 2, https://doi.org/10.14800/mr.1411

The objectives of this study were i) to investigate whether a novel biphasic collagen scaffold supports meniscal repair in an ovine meniscal defect model in vivo, ii) to investigate meniscal cell ingrowth and ECM production in an ex-vivo model and ii... Read More about A novel biphasic scaffold supports meniscal tissue repair in ex vivo and in vivo models.

PLA/chitosan/keratin composites for biomedical applications (2014)
Journal Article
Tanase, C. E., & Spiridon, I. (2014). PLA/chitosan/keratin composites for biomedical applications. Materials Science and Engineering: C, 40, 242-247. https://doi.org/10.1016/j.msec.2014.03.054

Novel composites based on PLA, chitosan and keratin was obtained via blend preparation. The goal of this contribution was to evaluate mechanical and in vitro behavior of the composites. The results point out composites with improved Young modulus and... Read More about PLA/chitosan/keratin composites for biomedical applications.

In vitroevaluation of biomimetic chitosan–calcium phosphate scaffolds with potential application in bone tissue engineering (2013)
Journal Article
Tanase, C. E., Sartoris, A., Popa, M. I., Verestiuc, L., Unger, R. E., & Kirkpatrick, C. J. (2013). In vitroevaluation of biomimetic chitosan–calcium phosphate scaffolds with potential application in bone tissue engineering. Biomedical Materials, 8(2), Article 025002. https://doi.org/10.1088/1748-6041/8/2/025002

This work reports on the physicochemical properties and in vitro cytotoxicity assessment of chitosan–calcium phosphate (Cs–CP) scaffolds for bone tissue engineering, which were synthesized by a novel biomimetic co-precipitation method. X-ray diffract... Read More about In vitroevaluation of biomimetic chitosan–calcium phosphate scaffolds with potential application in bone tissue engineering.

Biomimetic bone scaffolds based on chitosan and calcium phosphates (2011)
Journal Article
Tanase, C., Popa, M., & Verestiuc, L. (2011). Biomimetic bone scaffolds based on chitosan and calcium phosphates. Materials Letters, 65(11), 1681-1683. https://doi.org/10.1016/j.matlet.2011.02.077

This paper reports a novel biomimetic technique for obtaining chitosan–calcium phosphate composite scaffolds (Cs–CP) by calcium phosphate precipitation from its precursors,CaCl2 and NaH2PO4 in the presence of ammonia and Cs, followed by product freez... Read More about Biomimetic bone scaffolds based on chitosan and calcium phosphates.