Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention: A Controlled Post-hoc Trial

Navas-Carretero, Santiago; San-Cristobal, Rodrigo; Siig Vestentoft, Pia; Brand-Miller, Jennie C.; Jalo, Elli; Westerterp-Plantenga, Margriet; Simpson, Elizabeth J.; Handjieva-Darlenska, Teodora; Stratton, Gareth; Huttunen-Lenz, Maija; Lam, Tony; Muirhead, Roslyn; Poppitt, Sally; Pietiläinen, Kirsi H.; Adam, Tanja; Taylor, Moira A.; Handjiev, Svetoslav; McNarry, Melitta A.; Hansen, Sylvia; Brodie, Shannon; Silvestre, Marta P.; Macdonald, Ian A.; Boyadjieva, Nadka; Mackintosh, Kelly A.; Schlicht, Wolfgang; Liu, Amy; Larsen, Thomas M.; Fogelholm, Mikael; Raben, Anne; Martinez, J. Alfredo

doi:10.3389/fnut.2021.733697

Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention: A Controlled Post-hoc Trial

Navas-Carretero, Santiago; San-Cristobal, Rodrigo; Siig Vestentoft, Pia; Brand-Miller, Jennie C.; Jalo, Elli; Westerterp-Plantenga, Margriet; Simpson, Elizabeth J.; Handjieva-Darlenska, Teodora; Stratton, Gareth; Huttunen-Lenz, Maija; Lam, Tony; Muirhead, Roslyn; Poppitt, Sally; Pietiläinen, Kirsi H.; Adam, Tanja; Taylor, Moira A.; Handjiev, Svetoslav; McNarry, Melitta A.; Hansen, Sylvia; Brodie, Shannon; Silvestre, Marta P.; Macdonald, Ian A.; Boyadjieva, Nadka; Mackintosh, Kelly A.; Schlicht, Wolfgang; Liu, Amy; Larsen, Thomas M.; Fogelholm, Mikael; Raben, Anne; Martinez, J. Alfredo

Authors

Santiago Navas-Carretero

Rodrigo San-Cristobal

Pia Siig Vestentoft

Jennie C. Brand-Miller

Elli Jalo

Margriet Westerterp-Plantenga

Elizabeth J. Simpson

Teodora Handjieva-Darlenska

Gareth Stratton

Maija Huttunen-Lenz

Tony Lam

Roslyn Muirhead

Sally Poppitt

Kirsi H. Pietiläinen

Tanja Adam

Dr MOIRA TAYLOR moira.taylor@nottingham.ac.uk
ASSOCIATE PROFESSOR

Svetoslav Handjiev

Melitta A. McNarry

Sylvia Hansen

Shannon Brodie

Marta P. Silvestre

Ian A. Macdonald

Nadka Boyadjieva

Kelly A. Mackintosh

Wolfgang Schlicht

Amy Liu

Thomas M. Larsen

Mikael Fogelholm

Anne Raben

J. Alfredo Martinez

Abstract

Background: Individuals with pre-diabetes are commonly overweight and benefit from dietary and physical activity strategies aimed at decreasing body weight and hyperglycemia. Early insulin resistance can be estimated via the triglyceride glucose index {TyG = Ln [TG (mg/dl) × fasting plasma glucose (FPG) (mg/dl)/2]} and the hypertriglyceridemic-high waist phenotype (TyG-waist), based on TyG x waist circumference (WC) measurements. Both indices may be useful for implementing personalized metabolic management. In this secondary analysis of a randomized controlled trial (RCT), we aimed to determine whether the differences in baseline TyG values and TyG-waist phenotype predicted individual responses to type-2 diabetes (T2D) prevention programs. Methods: The present post-hoc analyses were conducted within the Prevention of Diabetes through Lifestyle intervention and population studies in Europe and around the world (PREVIEW) study completers (n = 899), a multi-center RCT conducted in eight countries (NCT01777893). The study aimed to reduce the incidence of T2D in a population with pre-diabetes during a 3-year randomized intervention with two sequential phases. The first phase was a 2-month weight loss intervention to achieve ≥8% weight loss. The second phase was a 34-month weight loss maintenance intervention with two diets providing different amounts of protein and different glycemic indices, and two physical activity programs with different exercise intensities in a 2 x 2 factorial design. On investigation days, we assessed anthropometrics, glucose/lipid metabolism markers, and diet and exercise questionnaires under standardized procedures. Results: Diabetes-related markers improved during all four lifestyle interventions. Higher baseline TyG index (p < 0.001) was associated with greater reductions in body weight, fasting glucose, and triglyceride (TG), while a high TyG-waist phenotype predicted better TG responses, particularly in those randomized to physical activity (PA) of moderate intensity. Conclusions: Two novel indices of insulin resistance (TyG and TyG-waist) may allow for a more personalized approach to avoiding progression to T2D. Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT01777893 reference, identifier: NCT01777893.

Citation

Navas-Carretero, S., San-Cristobal, R., Siig Vestentoft, P., Brand-Miller, J. C., Jalo, E., Westerterp-Plantenga, M., Simpson, E. J., Handjieva-Darlenska, T., Stratton, G., Huttunen-Lenz, M., Lam, T., Muirhead, R., Poppitt, S., Pietiläinen, K. H., Adam, T., Taylor, M. A., Handjiev, S., McNarry, M. A., Hansen, S., Brodie, S., …Martinez, J. A. (2021). Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention: A Controlled Post-hoc Trial. Frontiers in Nutrition, 8, Article 733697. https://doi.org/10.3389/fnut.2021.733697

Journal Article Type	Article
Acceptance Date	Sep 24, 2021
Online Publication Date	Nov 1, 2021
Publication Date	Nov 1, 2021
Deposit Date	Nov 25, 2022
Publicly Available Date	Dec 8, 2022
Journal	Frontiers in Nutrition
Electronic ISSN	2296-861X
Publisher	Frontiers Media
Peer Reviewed	Peer Reviewed
Volume	8
Article Number	733697
DOI	https://doi.org/10.3389/fnut.2021.733697
Keywords	Nutrition and Dietetics; Endocrinology, Diabetes and Metabolism; Food Science
Public URL	https://nottingham-repository.worktribe.com/output/6791160