Skip to main content

Research Repository

Advanced Search

The Role of Chronic Inflammation in Polycystic Ovarian Syndrome—A Systematic Review and Meta-Analysis

Aboeldalyl, Shaimaa; James, Cathryn; Seyam, Emaduldin; Ibrahim, Emad Moussa; Shawki, Hossam El-Din; Amer, Saad

The Role of Chronic Inflammation in Polycystic Ovarian Syndrome—A Systematic Review and Meta-Analysis Thumbnail


Authors

Shaimaa Aboeldalyl

Cathryn James

Emaduldin Seyam

Emad Moussa Ibrahim

Hossam El-Din Shawki

Profile Image

SAAD AMER saad.amer@nottingham.ac.uk
Professor of Gynaecology and Reproductive Medicine



Abstract

Although the current literature associates polycystic ovarian syndrome (PCOS) with chronic inflammation, the evidence for this link remains inconclusive and its causal nature remains unclear. The purpose of this systematic review was to assess the inflammatory status in PCOS women and to determine whether it is related to PCOS or to its associated adiposity. We searched electronic databases including PUBMED, EMBASE and MEDLINE, SCOPUS, DynaMed plus, TRIP, ScienceDirect and Cochrane Library, for studies investigating C-reactive protein (CRP) and other inflammatory makers in PCOS women versus healthy controls. Quality and risk of bias for selected studies were assessed using the modified Newcastle–Ottawa scale. CRP data were extracted and pooled using RevMan for calculation of the standardized mean difference (SMD) and 95% confidence interval (CI). Eighty-five eligible studies were included in the systematic review, of which 63 were included in the meta-analysis. Pooled analysis of the 63 studies revealed significantly higher circulating CRP in PCOS women (n = 4086) versus controls (n = 3120) (SMD 1.26, 95%CI, 0.99, 1.53). Sensitivity meta-analysis of 35 high quality studies including non-obese women showed significantly higher circulating CRP in PCOS women versus controls (SMD 1.80, 95%CI, 1.36, 2.25). In conclusion, circulating CRP is moderately elevated in PCOS women independent of obesity, which is indicative of low-grade chronic inflammation.

Citation

Aboeldalyl, S., James, C., Seyam, E., Ibrahim, E. M., Shawki, H. E., & Amer, S. (2021). The Role of Chronic Inflammation in Polycystic Ovarian Syndrome—A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences, 22(5), Article 2734. https://doi.org/10.3390/ijms22052734

Journal Article Type Article
Acceptance Date Mar 4, 2021
Online Publication Date Mar 8, 2021
Publication Date Mar 8, 2021
Deposit Date Mar 14, 2021
Publicly Available Date Mar 28, 2024
Journal International Journal of Molecular Sciences
Print ISSN 1661-6596
Electronic ISSN 1422-0067
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 22
Issue 5
Article Number 2734
DOI https://doi.org/10.3390/ijms22052734
Keywords polycystic ovarian syndrome; chronic inflammation; inflammatory markers; C-reactive protein; insulin resistance; obesity
Public URL https://nottingham-repository.worktribe.com/output/5394403
Publisher URL https://www.mdpi.com/1422-0067/22/5/2734

Files





You might also like



Downloadable Citations