Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response

Vishwakarma, Ajaykumar; Bhise, Nupura S.; Evangelista, Marta B.; Rouwkema, Jeroen; Dokmeci, Mehmet R.; Ghaemmaghami, Amir M.; Vrana, Nihal Engin; Khademhosseini, Ali

Abstract

Current state-of-the-art biomedical implants and tissue engineering methods promise technologies to improve or even restore the function of diseased organs. However, one of the biggest challenges to clinical success is the lack of functional integration. A series of cellular and molecular events following biomaterial implantation poses an important bottleneck for developing breakthrough solutions. With inflammation increasingly recognized as a crucial component influencing regeneration, immunomodulation or immuno-engineering has emerged as a potential solution to overcome this key challenge in regenerative medicine. We postulate possibilities to utilize biomaterial physicochemical modifications to modulate the host inflammatory response and develop strategies for effective biomaterial integration. Biomaterial-based immunomodulation strategies can significantly ameliorate the outcomes of medical implants and tissue engineering therapies.

Citation

Vishwakarma, A., Bhise, N. S., Evangelista, M. B., Rouwkema, J., Dokmeci, M. R., Ghaemmaghami, A. M., …Khademhosseini, A. (2016). Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response. Trends in Biotechnology, 34(6), 470-482. https://doi.org/10.1016/j.tibtech.2016.03.009

• Journal Article Type: Article
• Acceptance Date: May 2, 2016
• Online Publication Date: Apr 29, 2016
• Publication Date: Jun 1, 2016
• Deposit Date: Aug 19, 2022
• Journal: Trends in Biotechnology
• Print ISSN: 0167-7799
• Electronic ISSN: 1879-3096
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 34
• Issue: 6
• Pages: 470-482
• DOI: https://doi.org/10.1016/j.tibtech.2016.03.009
• Public URL: https://nottingham-repository.worktribe.com/output/3097195
• Publisher URL: https://www.cell.com/trends/biotechnology/fulltext/S0167-7799(16)30004-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS016777991630004X%3Fshowall%3Dtrue